Results 31 to 40 of about 124,299 (285)

Peptide‐based ligand antagonists block a Vibrio cholerae adhesin

FEBS Letters, EarlyView.
The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang, Grace Du, Charity Yongo‐Luwawa, Angelina Lu, Brett Kinrade, Kim Munro, Karl E. Klose, William D. Lubell, Peter Davies, Shuaiqi Guo   +9 more
wiley   +1 more source

Genome-Wide Identification and Analysis of GATA Gene Family in Dendrobium officinale Under Methyl Jasmonate and Salt Stress

Plants
Dendrobium officinale, which was rich in bioactive compounds such as polysaccharides, alkaloids, amino acids, and flavonoids, had significant medicinal value and ability to resist stresses. Studies had demonstrated that GATA genes were one of the crucial
Zhangting Xu, Feixiong Zheng, Xiaoji Deng, Yiming Sun, Zhenming Yu, Xiaoxia Shen   +5 more
doaj   +1 more source

Phytonutrient Composition of Two Phenotypes of Physalis alkekengi L. Fruit

Horticulturae, 2022
Physalis alkekengi L. is the only representative of the genus Physalis (Solanaceae) that is native to Bulgaria, found in wild habitats under different climatic and soil conditions.
Venelina Popova, Nadezhda Mazova, Tanya Ivanova, Nadezhda Petkova, Magdalena Stoyanova, Albena Stoyanova, Sezai Ercisli, Amine Assouguem, Mohammed Kara, Samar Zuhair Alshawwa, Omkulthom Al Kamaly   +10 more
doaj   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

Survivin and Aurora Kinase A control cell fate decisions during mitosis

Molecular Oncology, EarlyView.
Aurora A interacts with survivin during mitosis and regulates its centromeric role. Loss of Aurora A activity mislocalises survivin, the CPC and BubR1, leading to disruption of the spindle checkpoint and triggering premature mitotic exit, which we refer to as ‘mitotic slippage’.
Hana Abdelkabir, Shalitha Wickrama Arachchige, Sally P. Wheatley   +2 more
wiley   +1 more source

Technological and sensory characteristics of honey based candy [PDF]

BIO Web of Conferences
The aim of the present work was to investigate the possibilities of sugar replacing with honey in candies processing. Four candy samples were examined. Honey based groups - 10% (M10), 15% (M15) and 20% (M20) honey and sugar substitute - isomalt, compared
Yankova-Nikolova Anastasia, Hadjikinova Raina, Opalchenova Gabriela, Vlahova-Vangelova Desislava   +3 more
doaj   +1 more source

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source

Physicochemical parameters and antioxidant activity of summer savory essential oil (Satureja hortensis L.) [PDF]

BIO Web of Conferences
Summer savory (Satureja hortensis L.), Lamiaceae family, was used in folk medicine and food industry, and the resulting essential oil was used to flavor various food products, as well as a biologically active substance in cosmetics.
Gandova Vanya, Lazarov Anton, Petkova Nadezhda, Stoyanova Albena   +3 more
doaj   +1 more source

Improving PARP inhibitor efficacy in bladder cancer without genetic BRCAness by combination with PLX51107

Molecular Oncology, EarlyView.
Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz, Anna L. Bartkowiak, Michael Rose, Nora Kolks, Patrick Petzsch, Vandana Solanki, Anne Stoffel, Bianca Faßbender, Leandra Lepping, Julka Volkamer, Karl Köhrer, Marc Seifert, Tokameh Mahmoudi, Tahlita C. M. Zuiverloon, Günter Niegisch, Michèle J. Hoffmann   +15 more
wiley   +1 more source

Variation in chemical components and biological activity of Pterocarya fraxinifolia Lam. stems at different developmental stages [PDF]

Research Journal of Pharmacognosy, 2017
Background and objectives: Pterocarya fraxinifolia Lam. is a deciduous, fast-growing tree from walnut family. The stem barks and fruits of the plant have been used as diaphoretic in traditional medicine.
M. Akhbari, S. Tavakoli, S.M. Hosseinizadeh, E. Vatankhah, A. Hadjiakhoondi, M. Vazirian   +5 more
doaj