Results 21 to 30 of about 2,909,809 (211)

Isolated ten-eleven translocation 2 positive in triple negative essential thrombocythemia: Case report and literature review

SAGE Open Medical Case Reports, 2021
Essential thrombocythemia is one of the famous diseases under the category of myeloproliferative disorder. It is an end result of a genetic mutation of one or more of the most frequent oncogenes such as Janos kinase 2 (JAK2), MPL proto-oncogene ...
Rehab Y AL-Ansari, Dena Al Otaibi, Nourah Al Hudaithi, Leena Abdalla   +3 more
doaj   +1 more source

Studies of JAK2 mutations in myeloproliferative disorders [PDF]

, 2008
Myeloproliferative disorders (MPD) are diseases characterized by clonal hematopoiesis with overprodution of mature cells from erythroid, megakaryocytic and myeloid lineages.
Li, Sai
core   +1 more source

Pregnancy with Essential Thrombocythemia: A Case Report

Taiwanese Journal of Obstetrics & Gynecology, 2004
Objective: We describe a woman with essential thrombocythemia (ET) who experienced a successful pregnancy with no specific treatment. Case Report: A 30-year-old primiparous female was incidentally found to have ET with no specific symptoms at a ...
Yin-Jou Chou, Yu-Che Ou, Shiuh-Young Chang, Te-Yao Hsu   +3 more
doaj   +1 more source

Telomerase Inhibitor Imetelstat in Patients with Essential Thrombocythemia. [PDF]

, 2015
BACKGROUND Imetelstat, a 13-mer oligonucleotide that is covalently modified with lipid extensions, competitively inhibits telomerase enzymatic activity. It has been shown to inhibit megakaryocytic proliferation in vitro in cells obtained from patients
Snyder, David S., McDevitt, Michael A, Röth, Alexander, Ottmann, Oliver G., Spitzer, Gary, Oppliger Leibundgut, Elisabeth, Odenike, Olatoyosi, Stuart, Monic, Ottmann, Oliver G, Baerlocher, Gabriela M., Daskalakis, Michael, Snyder, David S, Burington, Bart, McDevitt, Michael A.   +13 more
core   +2 more sources

Recurrent thrombosis of splanchnic and lower extremity arteries with essential thrombocythemia

SAGE Open Medical Case Reports, 2019
Essential thrombocythemia is a myeloproliferative neoplasm characterized by platelet aggregation and thrombosis. Clinically, essential thrombocythemia increases the risk of both thrombosis and bleeding. Essential thrombocythemia is more involved in micro-
Sung Min Jung, Heungman Jun
doaj   +1 more source

Distinguishing essential thrombocythemia JAK2V617F from polycythemia vera: limitations of erythrocyte values

Haematologica, 2019
Distinguishing essential thrombocythemia JAK2V617F from polycythemia vera is difficult because of shared mutation and phenotypic characteristics. The World Health Organization suggested hemoglobin and hematocrit values to diagnose polycythemia vera (PV),
Richard T. Silver, Spencer Krichevsky
doaj   +1 more source

Dynamics of mutations in patients with essential thrombocythemia treated with imetelstat. [PDF]

, 2020
In a phase-2 study, the telomerase inhibitor imetelstat induced rapid hematologic responses in all patients with essential thrombocythemia who were refractory or intolerant to prior therapies.
Snyder, David S., Olatoyosi Odenike, Gabriela M. Baerlocher, Gary Spitzer, David S. Snyder, Oliver G. Ottmann, McDevitt, Michael A, Michael A. McDevitt, Röth, Alexander, Alexander Röth, Ottmann, Oliver G., Spitzer, Gary, Monika Haubitz, Bart Burington, Oppliger Leibundgut, Elisabeth, Odenike, Olatoyosi, Ottmann, Oliver G, Baerlocher, Gabriela M., Haubitz, Monika, Snyder, David S, Burington, Bart, Elisabeth Oppliger Leibundgut, McDevitt, Michael A.   +22 more
core   +2 more sources

Late‐Onset Chorea in JAK2‐Associated Essential Thrombocythemia [PDF]

, 2021
Somatic mutations in JAK2 are associated with chronic myeloproliferative neoplasms (MPNs), including polycythemia vera, essential thrombocythemia, and primary myelofibrosis (PMF).
Mulroy, E, Di Lazzaro, G, Giulia Di Lazzaro, Koya Kutty, Shahedah, Shahedah, KK, Di Lazzaro, Giulia, Magrinelli, F, Mulroy, Eoin, Latorre, A, Anna Latorre, Shahedah Koya Kutty, Francesca Magrinelli, Bhatia, KP, Latorre, Anna, Eoin Mulroy, Bhatia, Kailash P, Kailash P. Bhatia, Magrinelli, Francesca   +17 more
core   +2 more sources

Essential Thrombocythemia in a Cat

Journal of Veterinary Internal Medicine, 1990
Abstarct The diagnosis of essential thrombocythemia in a cat was made by fulfilling the five applicable criteria set forth by the Polycythemia Vera Study Group forusein humans. The criteria were 1) a platelet count persistently above 600,000/μL, 2) a normal initial hematocrit that did not rise in response to iron therapy, 3) normal ...
A S, Hammer, C G, Couto, D, Getzy, M Q, Bailey   +3 more
openaire   +2 more sources

Hydroxyurea compared with anagrelide in high-risk essential thrombocythemia

Background: We conducted a randomized comparison of hydroxyurea with anagrelide in the treatment of essential thrombocythemia. Methods: A total of 809 patients with essential thrombocythemia who were at high risk for vascular events received low-dose ...
Revell P, for the United Kingdom Medical Research Council Primary Thrombocythemia 1 Study, Reilly JT, Campbell PJ, Wilkins BS, Bareford D, Woodcock BE, Wheatley K, Grigg AP, East CL, Harrison CN, van der Walt JD, Green AR, Buck G   +13 more
core   +5 more sources