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METOPROLOL IN ESSENTIAL TREMOR
The Lancet, 1980The tremor of a patient with debilitating essential tremor who could not take propranolol (because of severe asthma) was dramatically reduced when metoprolol tartrate was administered in standard doses. Metoprolol appears to be an excellent alternative antitremor drug to propranolol in such patients.
D, Jefferson, C D, Marsden
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The Bereitschaftspotential in essential tremor
Clinical Neurophysiology, 2010Essential tremor (ET) is an involuntary postural oscillation. It is unclear to which extent motor cortical activity in preparation of volitional movement is abnormal in ET. We measured the Bereitschaftspotential (BP) to address this question.Given the known influence of the cerebello-dentato-thalamo-cortical projection in the generation of the BP ...
Ming-Kuei, Lu +7 more
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Quetiapine and Essential Tremor
Clinical Neuropharmacology, 2002The safety and tolerability of quetiapine (up to 75 mg/day) as monotherapy on essential tremor were investigated in an open-label study in 10 patients. Five men and 5 women, with a mean age of 66.3 years, affected by essential tremor participated in the trial. They were treated with increasing doses of quetiapine to 75 mg/day over a 6-week period. Side
Federico, Micheli +3 more
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Physiologic and essential tremor
Neurology, 1986We studied physiologic and essential hand tremor using inertial loading; hand acceleration and forearm EMG data were analyzed by auto- and cross-spectral analysis. Early essential tremor was qualitatively similar to the 8- to 12-Hz component of physiologic tremor, suggesting that this tremor component is a forme fruste of essential tremor.
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Parkinsonism & Related Disorders, 2012
The pathology of essential tremor (ET) is increasingly being studied. The main findings include a reduction in cerebellar Purkinje cells, other pathological changes of cerebellar degeneration and restricted Lewy bodies in the locus ceruleus. This paper will review those findings and put them into context with clinical studies in ET and findings in ...
Holly A, Shill +2 more
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The pathology of essential tremor (ET) is increasingly being studied. The main findings include a reduction in cerebellar Purkinje cells, other pathological changes of cerebellar degeneration and restricted Lewy bodies in the locus ceruleus. This paper will review those findings and put them into context with clinical studies in ET and findings in ...
Holly A, Shill +2 more
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Primidone and essential tremor
Journal of Neurology, 1988To clarify whether primidone itself, and not only its metabolite phenobarbitone, suppresses essential tremor, the effect of a high single dose of primidone was tested. Of 11 patients, 8 showed a reduction of their tremor by 54%-69% for up to 28 h.
S, Seyfert, A, Honé, G, Holl
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Management of essential tremor
Current Neurology and Neuroscience Reports, 2002Essential tremor (ET) is the most prevalent tremor syndrome. It commonly affects the hands, head, voice, and other body parts. Appropriate management begins with correct diagnosis. Primidone and propranolol are the first-line medications for the treatment for ET, but several other medications may also provide benefit.
Theresa A, Zesiewicz +2 more
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Flunarizine in Essential Tremor
Clinical Neuropharmacology, 1993We studied the effects of flunarizine (Fz) in 10 patients with moderate to severe essential tremor. Tremor was evaluated after 6 weeks of treatment using patient and physician assessment as well as blinded video analysis. Only one patient had mild subjective transient improvement and three experienced worsening of tremor.
T, Curran, A E, Lang
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Parkinsonism & Related Disorders, 2012
Classically, essential tremor (ET) was defined by the Movement Disorder Society Consensus Statement on Tremor (1998) as "a bilateral, largely symmetric postural or kinetic tremor involving hands and forearms that is visible and persistent". Additional or isolated tremor of the head may occur but in the absence of abnormal posture. Duration is more than
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Classically, essential tremor (ET) was defined by the Movement Disorder Society Consensus Statement on Tremor (1998) as "a bilateral, largely symmetric postural or kinetic tremor involving hands and forearms that is visible and persistent". Additional or isolated tremor of the head may occur but in the absence of abnormal posture. Duration is more than
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Phenobarbitone in essential tremor
Neurology, 1985We conducted a double-blind, placebo-controlled trial of phenobarbitone on a fixed-dose regimen in 12 patients with essential tremor. The drug was better than placebo on accelerometric measurement and clinical assessment, but not according to patient self-assessment or measures of manual performance.
L J, Findley, L, Cleeves
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