Results 31 to 40 of about 58,742 (222)

Chromosome level assembly of the hybrid Trypanosoma cruzi genome

open access: yesBMC Genomics, 2009
Background In contrast to the essentially fully assembled genome sequences of the kinetoplastid pathogens Leishmania major and Trypanosoma brucei the assembly of the Trypanosoma cruzi genome has been hindered by its repetitive nature and the fact that ...
Tarleton Rick L   +2 more
doaj   +1 more source

Recognition of the Content of the Norm as Unconstitutional by the Constitutional Court of Georgia – Theoretical Observations and Practical Challenges [PDF]

open access: yesJournal of Constitutional Law, 2023
Constitutional review of norms is a mechanism established by the Constitution of Georgia, the use of which naturally places the Constitutional Court of Georgia in a kind of institutional conflict with other branches or organs of the government (such as ...
Davit Abesadze
doaj  

Epigenetic blind spots – the role of DNA methylation dynamics in stem cell‐based models of embryogenesis

open access: yesFEBS Letters, EarlyView.
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil   +4 more
wiley   +1 more source

In Defense of the Internal Aspects View: Person-Affecting Reasons, Spectrum Arguments and Inconsistent Intuitions

open access: yesLaw, Ethics and Philosophy, 2015
According to the Internal Aspects View, the value of different outcomes depends solely on the internal features possessed by each outcome and the internal relations between them. This paper defends the Internal Aspects View against Larry Temkin’s defence
Oscar Horta
doaj  

Complex communication signals: the case of the Blue-black Grassquit Volatinia jacarina (Aves, Emberizidae) song. Part I - A structural analysis

open access: yesAnais da Academia Brasileira de Ciências, 2004
The song of the Blue-black Grassquit Volatinia jacarina is different for every individual and the structural differences between individuals are quite complex.
Hernán Fandiño-Mariño   +1 more
doaj   +1 more source

Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations

open access: yesFEBS Letters, EarlyView.
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas   +6 more
wiley   +1 more source

Rethinking the Good – A Small Taste

open access: yesLaw, Ethics and Philosophy, 2015
This article aims to convey a few of the key claims and arguments of my book, Rethinking the Good: Moral Ideals and the Nature of Practical Reasoning. The article gives an example of a Spectrum Argument, and illustrates that such arguments put pressure ...
Larry Temkin
doaj  

A Comparative Analysis of Farmers' Suicides in Andhra Pradesh, India

open access: yesMethodological Innovations, 2007
The agrarian distress in the Indian countryside has become a subject of major policy concern in view of the recent spate of suicides by farmers in a number of states like Maharashtra, Karnataka, Andhra Pradesh and Punjab.
Namrata Chindarkar
doaj   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

open access: yesFEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa   +2 more
wiley   +1 more source

Reply to Horta: Spectrum Arguments, the “Unhelpfulness” of Rejecting Transitivity, and Implications for Moral Realism

open access: yesLaw, Ethics and Philosophy, 2015
This article responds to Oscar Horta’s article “In Defense of the Internal Aspects View: Person-Affecting Reasons, Spectrum Arguments and Inconsistent Intuitions”. I begin by noting various points of agreement with Horta.
Larry Temkin
doaj  

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