Results 51 to 60 of about 58,657 (212)

A Comparative Study of the Ideas of Language Philosophers and Shia Usul Scholars on the Ontology of Meaning [PDF]

open access: yesپژوهش‌نامه کلام تطبیقی شیعه
The problem of this article is semantics and discussion of the ontology of meaning. In fact, this article deals with the ontological approach in meaning. Existential approach and nonexistent approach.
Mohammad Sadeq Kamelan   +2 more
doaj   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

open access: yesMolecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson   +9 more
wiley   +1 more source

Longitudinal genome‐wide aneuploidy measurements in circulating cell‐free DNA to predict lack of benefit from pembrolizumab in patients with metastatic urothelial cancer

open access: yesMolecular Oncology, EarlyView.
Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi   +14 more
wiley   +1 more source

On Governance, One Concept and Two Contents? [PDF]

open access: yesدولت‌پژوهی
Some concepts fall victim to their success. Such is the case with the idea of governance in the Islamic Republic of Iran. A vigilant observer notes that this concept is commonly used by politicians and certain elites without any serious consideration ...
Madjid Vahid, Christian Velud
doaj   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

open access: yesMolecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq   +8 more
wiley   +1 more source

Krytyczna analiza propozycji dekryminalizacji przestępstwa zniesławienia

open access: yesStudia Prawa Publicznego
There is a noticeable view in the social space about the need to decriminalise the offence of defamation. Such a position is unfounded and is not based on factual and scientific grounds and, in particular, does not take into account the constitutional ...
Marcin Sikora
doaj   +1 more source

Mass spectrometry based identification of AMP‐O‐Tris generated by Thermococcus onnurineus Cas10

open access: yesFEBS Open Bio, EarlyView.
Isolated Thermococcus onnurineus Cas10 generates the noncanonical ATP‐derived product AMP‐O‐Tris while in Tris‐containing buffer as identified via mass spectrometry, revealing relaxed nucleophile selectivity under isolated conditions. These findings suggest that multiprotein Csm complex assembly restricts Cas10 reactivity toward canonical cyclic ...
Su‐Jin Lee   +6 more
wiley   +1 more source

Why human connection is the true metric of research success

open access: yesFEBS Open Bio, EarlyView.
Human‐centred mentorship can be shaped by mentor attributes, actions, intrinsic drive and career ambition. Drawing on reflections across Singapore and France, as well as workshop insights from FEBS‐IUBMB ENABLE 2024, this article shows that human‐centred mentorship creates the conditions for sustainable growth, well‐being and retention in research ...
Timothy Lin Yun Tan   +3 more
wiley   +1 more source

The Right of Access to Justice of Individuals in Transnational Antimonopoly Disputes in the Eurasian Economic Union: the Ways of Overcoming the Crisis

open access: yesМосковский журнал международного права
INTRODUCTION. The article essentially deals with the legal mechanism of challenging the Eurasian Economic Commission’s (EEC) acts in the sphere of antimonopoly regulation by individuals in relation to their right of access to justice.MATERIALS AND ...
S. V. Maksimov, A. A. Filimonenko
doaj   +1 more source

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