Results 161 to 170 of about 3,580,464 (286)

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

Pre- and Post-establishment Factors Affecting the Perceived Sustainability of Midwifery Outpatient Clinics: An Exploratory Cross-Sectional Study in Japan. [PDF]

Cureus
Maeda A, Nakai H.
europepmc   +1 more source

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

FEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva, Puspa Kunwar, Md Ibnul Rifat Rahman, Joanna Koryo Kwao, Nathan Lehman, Zihan Zhang, Trenton Paul, Claire Cheng, Nicholas Truex, Hui‐Ting Lee, Jun Zhang   +10 more
wiley   +1 more source

Viral haemorrhagic septicaemia virus, infectious haematopoietic necrosis virus and HPR-deleted infectious salmon anaemia virus - Risk of introduction in free areas through fertilised eggs and gametes. [PDF]

EFSA J
EFSA Panel on Animal Health and Welfare (AHAW), Nielsen SS, Alvarez J, Boklund A, Dippel S, Figuerola J, Herskin MS, Michel V, Miranda Chueca MA, Nannoni E, Nonno R, Riber AB, Ståhl K, Stegeman JA, Thulke HH, Tuyttens F, Winckler C, Christiansen DH, Olesen NJ, Rimstad E, Toffan A, Vendramin N, Papaleo S, Preite L, Baldinelli F, Dórea F.   +25 more
europepmc   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Overwintering Capacity of the Mediterranean Fruit Fly in the Dalmatia Region of Croatia. [PDF]

Insects
Bjeliš M, Tavra I, Strikić F, Popović L, Moraiti CA, Rodovitis VG, Papadopoulos NT.   +6 more
europepmc   +1 more source

Physics Department. Annual progress report 1 January - 31 December 1973 [PDF]

, 1973
Research Establishment Risø, Roskilde
core   +3 more sources

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

An interactive heuristic model to test ecological and evolutionary hypotheses on incipient polyploid species. [PDF]

Sci Rep
Schneider JS, Reutemann AV, Sassone AB, Honfi AI, Hojsgaard DH.   +4 more
europepmc   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source