Results 211 to 220 of about 182,430 (285)

Autism Spectrum Disorder Among Gender‐Diverse Children and Adolescents: A National Cohort Study

Autism Research, EarlyView.
ABSTRACT Autism spectrum disorder (ASD) is more prevalent in transgender and gender‐diverse (TGD) individuals than in the general population, yet the specific developmental pathways within and clinical outcomes of this intersection are insufficiently understood.
Erez Topaz, Tamar Sheppes, Anat Segev‐Becker, Galit Israeli, Asaf Oren, Yael Lebenthal, Tomer Shechner, Liat Perl   +7 more
wiley   +1 more source

Endobacteria Have a Negative Effect on the Virulence of <i>Metarhizium</i>. [PDF]

J Fungi (Basel)
Mora-Acebedo AG, Aguilar IR, Martínez-Vázquez A, Piña-Torres IH, Castellanos AD, Nieves-López ZF, Contreras-Garduño J, González-Hernández GA, Padilla-Guerrero IE, Torres-Guzmán JC.   +9 more
europepmc   +1 more source

Mechanism‐informed machine learning for individualized tacrolimus dose adjustment in the early post‐kidney transplant period

British Journal of Clinical Pharmacology, EarlyView.
Abstract Aim Tacrolimus dosing in the early post‐kidney transplant period is challenging due to a narrow therapeutic index and substantial interindividual pharmacokinetic (PK) variability. This study aimed to develop and validate mechanism‐informed machine learning (ML) models to support individualized tacrolimus dosing during this critical period ...
Hui Yu, Zihan Qin, Logan S. Smith, Jeong M. Park, Hao‐Jie Zhu   +4 more
wiley   +1 more source

Case series: effects of platelet-rich plasma (PRP) on the recovery of bilateral muscle injuries after removal of semitendinosus and gracilis grafts in bilateral anterior cruciate ligament (ACL) reconstruction. [PDF]

J Surg Case Rep
De Castro Pochini A, Bueno AC, Mattos RAC, Ejnisman B, Cohen M.   +4 more
europepmc   +1 more source

Efficacy, safety and cost‐effectiveness of CAR‐T therapy

British Journal of Clinical Pharmacology, EarlyView.
CAR T‐cells demonstrate high efficacy in blood cancers, including ALL, MM and DLBCL. Innovations target solid tumours despite challenges such as antigen escape. Combination therapies enhance the delivery and infiltration of CAR T cells. Toxicity, cost and resistance remain major barriers to clinical use.
Emina Karahmet Sher, Amina Džidić‐Krivić, Emma Pinjic, Nejra Selak, Kanita Omerbasic, Alexandar Chupin, Andrej Belancic, Almir Fajkic   +7 more
wiley   +1 more source

Sperm plasma membrane potential as a marker for fertilization success for non-normozoospermic patients undergoing assisted reproduction technologies. [PDF]

J Assist Reprod Genet
Carrasquel-Martínez G, Torres-Rodríguez P, Matamoros-Volante A, Flores DL, Figueroa-Méndez MG, Rosas IM, Aragón-Martínez A, Treviño CL.   +7 more
europepmc   +1 more source

Paternal use of metformin and risk of major congenital malformations: A meta‐analysis of 4 studies

British Journal of Clinical Pharmacology, EarlyView.
Abstract Metformin is the first‐line drug for the treatment of Type 2 diabetes. In 2022, a Danish registry‐based study reported a 40% increased risk of major congenital malformations following paternal exposure during spermatogenesis. This raised widespread concern about the use of metformin in males of reproductive age.
Per Damkier, Marleen M. H. J. van Gelder, Krista F. Huybrechts, Lin‐Chieh Meng, Sonia Hernandez‐Diaz, Jan Nielsen, Bente M. Nørgård, Hedvig Nordeng   +7 more
wiley   +1 more source

Advanced therapy medicinal products (ATMPs) – An analysis of the global regulatory status

British Journal of Clinical Pharmacology, EarlyView.
Abstract Background A rapid progress in the development of advanced therapy medicinal products (ATMPs) has taken place over the past decades. The ATMPs hold great potential but face challenges in the clinical development and the regulatory process.
Allan Cramer, Freja Karuna Hemmingsen Sørup, Marie Lund, Tonny Studsgaard Petersen, Kristian Karstoft   +4 more
wiley   +1 more source