Results 71 to 80 of about 381,853 (304)

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham, Jasibel Vasquez‐Gonzalez, Samantha M. Barnada, Salome Tchotorlishvili, Latese Jones, Ryan Maguire, Genevieve Lewis, Kinza Rizwan, Jenny Deng, Salma Koachar, Drithi Patel, Hailey Shankle, Tessa Mulders, Namra Ajmal, Charalambos Solomides, Emad S. Alnemri, Teresa F. Alnemri, Ayesha A. Shafi, Leonard G. Gomella, Wm Kevin Kelly, Steven B. McMahon, Matthew J. Schiewer   +21 more
wiley   +1 more source

Ideología racial, práctica social y Estado Liberal en Costa Rica

Revista de Historia, 1999
Introducción Hace unos años escuchamos a un amigo describir a una afrolimonense conocida suya de esta manera: “¡Que mujerzota, maje! Tiene el cuerpo de una negra y la cara de una blanca.” Tal comentario, de ninguna manera fuera de contexto en los ...
Lara Elizabeth Putnam
doaj  

Estado liberal y Estado totalitario

Revista Ciencias Humanas
La idea marcuseana de que en el seno de la sociedad liberal se va preparando lenta y paulatinamente la concepción totalitaria y, por consiguiente, el estado totalitario sirve de pretexto para unas reflexiones sobre la responsabilidad de dicha sociedad en la complejidad de la guerra. Efectivamente, si de algo decía estar seguro Marcuse había sido que el
openaire   +1 more source

Origens e Desenvolvimento do Ativismo Judicial: Do Estado Liberal ao Estado Social.

Teorias do Direito e Realismo Jurídico, 2016
Este artigo analisará o ativismo judicial respondendo à seguinte indagação: como o papel do Poder Judiciário se modificou com o desenvolvimento dos modelos de Estado? O artigo desenvolverá seu problema analisando a função do Poder Judiciário em cada um destes modelos de Estado de Direito: o Liberal, o Social (em que pese tal Estado não ter sido ...
Alexandre Luna da Cunha, Maria Cristina Zainaghi   +1 more
openaire   +1 more source

La cuestión de la regeneración de la raza en el discurso educativo del laicismo (Ensayos) [PDF]

, 2018
Pese a que el discurso laicista ecuatoriano se inspiró en una utopía educativa de corte integrador e igualitarista, que emergió como la expectativa más importante del triunfo de la revolución liberal de 1895, aparece años más tarde impregnado de ...
Terán Najas, Rosemarie
core  

Integrated genomic and proteomic profiling reveals insights into chemoradiation resistance in cervical cancer

Molecular Oncology, EarlyView.
A comprehensive genomic and proteomic analysis of cervical cancer revealed STK11 and STX3 as a potential biomarkers of chemoradiation resistance. Our study demonstrated EGFR as a therapeutic target, paving the way for precision strategies to overcome treatment failure and the DNA repair pathway as a critical mechanism of resistance.
Janani Sambath, Irene A. George, Srikanth S. Manda, Prasanth Ariyannur, Ekta R. Dhawale, Raja Sekhar Kommu, Rajan Datar, Darshana Patil, Vinita Trivedi, Manisha Singh, Kumar Prabhash, Sewanti Limaye, Richa Chauhan, Prashant Kumar   +13 more
wiley   +1 more source

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Santo Estado, maldito mercado: de certas esquerdas que são direitas Holy State, damned market: about certain left wings that are right wings

Sociedade e Estado, 2005
É comum na discussão sobre política social e desenvolvimento preservar o Estado e sacrificar o mercado. Historicamente falando, a apreciação positiva do papel do Estado vincula-se ao welfare state, que, mesmo tendo sido fenômeno relativamente curto e ...
Pedro Demo
doaj   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

Para un proyecto nuevo de nación

Theoría Revista del Colegio de Filosofía, 2009
From the central thesis that the Mexican nation is divided, the author shows us as means the possibilities for an alternative national plan. In the centre of the text, Villoro emphhasizes the characteristics of a communal democracy; the author proposes ...
Luis Villoro
doaj   +1 more source