Results 91 to 100 of about 2,138 (256)
The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers
Molecular Oncology, EarlyView.The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce +11 more
wiley +1 more source
El derecho a la transparencia algorítmica como estándar ético en una democracia liberal
Revista Jurídica AustralLos algoritmos han transformado la vida de las personas y la relación con el Estado. Cada vez más, los Estados recurren a esta tecnología para desempeñar sus funciones.
Wilfredo Concha Camacho
doaj +1 more source
BRASIL: ESTADO INTERVENCIONISTA OU LIBERAL?
REVISTADAACADEMIABRASILEIRADEDIREITOCONSTITUCIONAL, 2019 Átila de Alencar Araripe Magalhães +1 more
openaire +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Molecular Oncology, EarlyView.Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano +6 more
wiley +1 more source
Ética e política: observações sobre o liberalismo de Benedetto Croce
Reflexão, 2015 O presente artigo trata de alguns aspectos do pensamento político de Benedetto Croce, buscando explicitar alguns conceitos expressos na obra Ética e Política, a fim de compreender seu vínculo e sua contribuição para o pensamento liberal italiano ...
Anita Helena Schlesener
doaj
Ideologia liberal e construção do Estado do Brasil
Anais do Museu Paulista: História e Cultura Material, 1981 This paper inquires into the limits of the actuation of the principies of North-American liberalism in the process of building up the Brazilian State during the last century. These principies are opposed to the pressures exercised by forces of the counter-revolutionary ideology, among them the “haitinism”, a term used to convey the increasing dread of ...
openaire +2 more sources
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
Molecular Oncology, EarlyView.A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel +12 more
wiley +1 more source