Results 71 to 80 of about 2,138 (256)

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

open access: yesFEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Derecho De La Competencia: Del Estado Liberal Al Estado Social.

open access: yesAnuario de Derecho
En este artículo vemos como el Liberalismo es el que fundamento las codificaciones del orden ideológico y socioeconómico del siglo XIX, en donde el Estado asuma una postura diferente ante la economía de mercado debido a los cambios surgido. Causando el abandonó del iusnaturalismo que da lugar al positivismo del Derecho Estatal.
openaire   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

open access: yesFEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa   +2 more
wiley   +1 more source

A formação acadêmica dos revolucionários republicanos brasileiros no Séc. XIX

open access: yesRevista Histedbr On-line, 2013
Investigamos ao “espírito revolucionário” que fundamenta a crítica liberal no Brasil ao fim do século XIX destacando, como hipótese da sedição, a formação acadêmica dos sujeitos que reagem ao Estado nobiliário.
Adreana Dulcina Platt   +2 more
doaj   +1 more source

A clivagem Estado-Igreja na Monarquia Liberal (1820-1910)

open access: yesHistória: Revista da Faculdade de Letras da Universidade do Porto, 2020
After the serious conflict that opposed the Catholic Church to the liberal State in the 1820s and 1830s, in Portugal, the Church was deprived of its economic base and subject to the state control in the appointment of bishops and parish priests. But unlike other European countries, this cleavage did not, as has been tried, give rise to a relevant ...
openaire   +2 more sources

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

open access: yesFEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source

OS MODELOS DE ESTADO E AS CARACTERÍSTICAS DA JURISDIÇÃO A

open access: yesRevista Eletrônica do Curso de Direito da UFSM, 2008
O Estado Moderno, diferentemente das formas pré-modernas de organização, é caracterizado pela dominação burocrática. Apresentou-se inicialmente como Estado Absoluto, em face do qual se opôs o Estado Liberal e, posteriormente o Estado Social.
Ana Luísa Zago de Moraes
doaj   +1 more source

Design and analysis strategies for robust microbiome ageing research

open access: yesFEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik   +5 more
wiley   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

open access: yesFEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj   +3 more
wiley   +1 more source

A recuperação do espaço autônomo do político: o diagnóstico de uma fusão que desafia a lógica do liberalismo moderno

open access: yesCivitas - Revista de Ciências Sociais, 2004
O presente artigo tem por objetivo diagnosticar os desafios atuais que enfrenta a noção de Estado Liberal de Direito ante a emergência dos “novos” movimentos sociais, os quais apontam para os problemas estruturais que atravessa este modelo de estado ...
Vieira, Luiz Vicente
doaj  

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