Results 131 to 140 of about 270,121 (304)

PYCR1 inhibition in bone marrow stromal cells enhances bortezomib sensitivity in multiple myeloma cells by altering their metabolism

Molecular Oncology, EarlyView.
This study investigated how PYCR1 inhibition in bone marrow stromal cells (BMSCs) indirectly affects multiple myeloma (MM) cell metabolism and viability. Culturing MM cells in conditioned medium from PYCR1‐silenced BMSCs impaired oxidative phosphorylation and increased sensitivity to bortezomib.
Inge Oudaert, Lauren van den Broecke, Osman Aksoy, Judith Lind, Sonia Vallet, Arne Van der Vreken, Gamze Ates, Ann Massie, Ken Maes, Kim De Veirman, Elke De Bruyne, Karin Vanderkerken, Klaus Podar, Eline Menu   +13 more
wiley   +1 more source

Isquemia e reperfusão hepática total associada ao estado de choque hemorrágico controlado: efeitos no seqüestro de neutrófilos no íleo terminal e cólon sigmóide do rato

Revista do Colégio Brasileiro de Cirurgiões
OBJETIVO: Estudar os efeitos da isquemia e reperfusão hepática total sobre acúmulo de neutrófilos no íleo terminal e cólon sigmóide de ratos, em condições de normalidade e submetidos ao estado de choque hemorrágico controlado.
Mauro José Fontelles, Mario Mantovani
doaj   +1 more source

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

The tadpole of Physalaemus fernandezae (Anura: Leptodactylidae) [PDF]

, 2006
This paper describes the external and buccopharyngeal morphology, chondrocranium and cranial muscles in tadpoles of Physalaemus fernandezae. The data are compared with those for other species of Physalaemus to improve the diagnosis of the “species group”
Alcalde, Leandro, Cajade, Rodrigo, Natale, Guillermo Sebastian   +2 more
core  

Survivin and Aurora Kinase A control cell fate decisions during mitosis

Molecular Oncology, EarlyView.
Aurora A interacts with survivin during mitosis and regulates its centromeric role. Loss of Aurora A activity mislocalises survivin, the CPC and BubR1, leading to disruption of the spindle checkpoint and triggering premature mitotic exit, which we refer to as ‘mitotic slippage’.
Hana Abdelkabir, Shalitha Wickrama Arachchige, Sally P. Wheatley   +2 more
wiley   +1 more source

Desarrollo floral en cereales de invierno en distintas épocas de siembra

Semiárida, 2020
En trigo pan, trigo candeal y cebada cervecera, el ápice en estado de doble lomo y de espiguilla terminal diferenciada, marca el límite para realizar distintas prácticas agronómicas. El objetivo del presente trabajo fue estudiar el desarrollo del ápice y
C. A. Campanari
doaj  

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source

Plan de mejora de atención a la familia del paciente en estado terminal.

, 2017
La enfermedad terminal, por lo general, es una situación que suele generar mucho estrés, ansiedad y miedo a lo desconocido en los familiares de este tipo de paciente, produciéndoles así una disminución de su nivel de calidad de vida. La implantación de este proyecto de atención a las familias del paciente terminal como parte de la labor enfermera, nos ...
Guio Grande, Estefania, Ariño Lapuente, Miguel   +1 more
openaire   +1 more source

Reduced vascular leakage correlates with breast carcinoma T regulatory cell infiltration but not with metastatic propensity

Molecular Oncology, EarlyView.
A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He, Chiara Testini, Neda Hekmati, Altea Bonello, Aglaia Schiza, Emmanuel Nwadozi, Mia Phillipson, Carina Strell, Michael Welsh   +8 more
wiley   +1 more source

Modelos predictivos de desarrollo apical en trigo (Triticum aestivum L.), por características morfológicas externas

Semiárida, 2020
En el trigo (Triticum aestivum L.), el ápice en estado de doble lomo y de espiguilla terminal diferenciada, marcan los límites del período oportuno para realizar ciertas prácticas agronómicas.
S. E. Arisnabarreta, H. D. Mareque, D. S. Napal   +2 more
doaj