CPT: Pharmacometrics &Systems Pharmacology, Volume 14, Issue 3, Page 435-447, March 2025.Abstract Intranasal diamorphine (IND), approved for managing breakthrough pain in the UK, has been identified as an acceptable alternative offering effective, expedient, and less traumatic analgesia for children. However, the current dose regimen in pediatric populations relies on clinical expertise while the pharmacokinetics properties are poorly ...
Lianjin Cai +6 more
wiley +1 more source
Cloning and Characterization of GDSL Esterases from <i>Bacillus paralicheniformis</i> T7. [PDF]
Biology (Basel)Mussakhmetov A +3 more
europepmc +1 more source
Sequential Optimization of Multivariate Metal–Organic Framework Based Biocatalysis
Small, EarlyView.A sequential Latin hypercube sampling–coupled Bayesian optimization (LHS‐BO) workflow integrates multivariate zirconium‐based metal–organic framework based biocomposite (E‐MOF) design with enzyme biocascade reaction optimization. The optimized E‐MOFs stabilize glucose oxidase and horseradish peroxidase in bioactive conformation, exhibiting high ...
Weibin Liang +4 more
wiley +1 more source
Crystal Surface Reactivity of Esterase@Zeolitic Imidazolate Framework Biocomposites. [PDF]
J Am Chem SocBorrego-Marin E +7 more
europepmc +1 more source
Mechanism elucidation of cell‐selective fluorescent probes
Smart Molecules, EarlyView.This perspective outlines five mechanistic strategies—Protein‐oriented, carbohydrate‐oriented, lipid‐oriented, gating‐oriented, and metabolism‐oriented live‐cell distinctions—for achieving cell‐selective fluorescence in live‐cell imaging. By classifying probes based on their interactions with proteins, carbohydrates, lipids, transporters, or metabolic ...
Sourav Sarkar, Young‐Tae Chang
wiley +1 more source
Comparative study between female patients with functional dyspepsia accompanied by abnormal urinalysis and those with urinary tract infections: a retrospective case-control study. [PDF]
Sci RepLiao Y +6 more
europepmc +1 more source
Conductive Hydrogel‐Enabled Electrode for Scalp Electroencephalography Monitoring
Small Methods, EarlyView.Conductive hydrogels are emerging as effective EEG electrode‐scalp interfaces to overcome hair barriers. This review presents the demanding parameters for hair‐compatible hydrogel electrodes and summarizes their applications in healthcare and brain‐computer interfaces.
Zichong Ji +14 more
wiley +1 more source
Low-inflammatory response phenotypes in elderly urinary tract infections: pathogen type, antimicrobial resistance, and comorbidity-associated risk profiles. [PDF]
BMC GeriatrMing H +4 more
europepmc +1 more source
Advances in cholesterol and lipoproteins detection for healthcare: A review
VIEW, EarlyView.Cholesterol is one of the main biomarkers related to the development of cardiovascular diseases. Its detection still relies on traditional methods of analysis, such as gas and liquid chromatographies. Detection of free cholesterol in saliva with redox or enzymatic sensors or detection of lipoproteins in blood with aptamer sensors are currently the most
Jacopo Giaretta +7 more
wiley +1 more source
Below‐ground drivers of rhizosphere functional gene assembly during Moso bamboo expansion
Functional Ecology, EarlyView.Read the free Plain Language Summary for this article on the Journal blog. Abstract Moso bamboo (Phyllostachys edulis) expansion threatens subtropical forest biodiversity, yet how intraspecific root trait variation shapes rhizosphere microbial functional potential remains unclear.
Yaoxing Wu +8 more
wiley +1 more source