Results 171 to 180 of about 174,390 (285)

Production of Novel Thermostable Esterases from <i>Thermus thermophilus</i> Strain ET-1 in <i>Escherichia coli</i> and <i>Thermus thermophilus</i> HB27 Using the Bifunctional Expression System pTGT-1 and Characterization of the Recombinant Enzymes. [PDF]

Int J Mol Sci
Valenzuela B, Cayo M, Solís-Cornejo F, Reyes MB, Palma I, Uribe E, Zamorano P.   +6 more
europepmc   +1 more source

Evidence that 5‐HT2A receptor signalling efficacy and not biased agonism differentiates serotonergic psychedelic from non‐psychedelic drugs

British Journal of Pharmacology, EarlyView.
Background and Purpose Serotonergic psychedelic drugs are under investigation as therapies for various psychiatric disorders, including major depression. Although serotonergic psychedelic drugs are 5‐HT2A receptor agonists, some such agonists are not psychedelic, potentially due to differences in 5‐HT2A receptor ligand bias or signalling efficacy. Here,
Aurelija Ippolito, Sridhar Vasudevan, Shaun Hurley, Gary Gilmour, Frederick Westhorpe, Grant Churchill, Trevor Sharp   +6 more
wiley   +1 more source

Angiotensin-Converting Enzyme (ACE) Inhibitor-Induced Angioedema Presenting After Long-Term Antihypertensive Therapy: A Case Report. [PDF]

Cureus
Khalid M, Nafis S.
europepmc   +1 more source

Fenofibrate potentiates the therapeutic efficacy of EZH2 inhibitors on melanoma via TRIM21‐ and OTUD4‐mediated EZH2 ubiquitination

British Journal of Pharmacology, EarlyView.
Background and Purpose EZH2 (enhancer of zeste homologue 2) inhibitors are an emerging class of drugs that target epigenetic regulation. However, their efficacy in solid tumours has been limited, partly due to drug‐induced upregulation of fatty acid synthesis.
Rui Cheng, Yuanjun Tang, Xuedi Cao, Xiaotong Yu, Zhanya Huang, Yunyun Guo, Renjing Jin, Yan Wang, Yang Liu, Lixiang Xue, Yuqing Wang   +10 more
wiley   +1 more source

Unveiling a catalytically promiscuous feruloyl esterase from Clostridium acetobutylicum. [PDF]

Appl Microbiol Biotechnol
Li S, Hu X, Che X, Quan L, Li X, Feng T, Feng Y, Xue S.   +7 more
europepmc   +1 more source

ESTERASE IN LEUCOCYTES [PDF]

Journal of Histochemistry & Cytochemistry, 1959
openaire   +2 more sources

Novel drugs approved by the EMA, the FDA and the MHRA in 2025: A year in review

British Journal of Pharmacology, EarlyView.
Abstract In the 2025 novel drug mini‐review, one can take a full measure of the ingenuity that underlies current drug design and development, despite the year's smaller harvest (46 novel drugs) compared to 2024 (53) and 2023 (70). 54% of the novel drugs are first‐in‐class (FIC).
Andreas Papapetropoulos, Stavros Topouzis, Steve P. H. Alexander, Miriam M. Cortese‐Krott, Zsuzsanna Helyes, Kirill Martemyanov, Claudio Mauro, Nithyanandan Nagercoil, Reynold A. Panettieri Jr, Hemal H. Patel, Rainer Schulz, Barbara Stefanska, Gary J. Stephens, Nathalie Vergnolle, Xin Wang, Stephen Ward, Péter Ferdinandy   +16 more
wiley   +1 more source

From Brewing to Plastic Degradation: Uncovering the Polyurethanase Potential of <i>R. chinensis</i> Lipase through Atomistic Simulations. [PDF]

J Am Chem Soc
de Sousa Batista V, Ṡwiderek K, Moliner V.   +2 more
europepmc   +1 more source

Temperature-Dependent and Semi-Quantitative Enzyme Profiles of <i>Malacosoma disstria</i> (Lepidoptera: Lasiocampidae) Hemocytic Cell Lines. [PDF]

Cells
Giannoulis P, Kalorizou H.
europepmc   +1 more source

Physiological and behavioural effects of continuous remifentanil‐xylazine administration in donkeys

Equine Veterinary Journal, EarlyView.
Abstract Background Remifentanil and xylazine are used as continuous infusions to facilitate standing surgery in horses. Their use for this purpose has not been reported in donkeys. Objectives To evaluate the behavioural, sedative, and cardiorespiratory effects of continuous intravenous infusion of remifentanil and xylazine in donkeys. Study Design Non‐
Kássia Fernanda Araújo Damasceno, Andressa Nunes Mouta, Larissa de Sant' Ana Alves, Kathryn Nóbrega Arcoverde, Herbert Reis Aragão, Jerson Marques Cavalcante, Valéria Veras de Paula   +6 more
wiley   +1 more source