Results 51 to 60 of about 116,477 (304)
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
Genetic progress evaluation of growth traits in Moghani sheep [PDF]
Biotechnology in Animal Husbandry, 2023 For evaluation of growth traits' genetic progress, pedigree information of 39408 Moghani sheep, between 1986 to 2016, at the breeding station of Moghani sheep was used.
Esrafili Taze Kand Mohammaddiyeh Maryam +1 more
doaj
Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer
Molecular Oncology, EarlyView.COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann +61 more
wiley +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Molecular Oncology, EarlyView.Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau +8 more
wiley +1 more source
ESTIMATION OF HERITABILITY AND BREEDING VALUE OF PIGLET BIRTH WEIGHT [PDF]
, 2017 Piglet birth weight has an economic value and commonly correlated with weaning weigh. Therefore, birth weight traits of piglet needs to be selected for genetic improvement.
Nurgiartiningsih, V. M. Ani; Fakultas Peternakan, Universitas Brawijaya +2 more
core +1 more source
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Temporal variation in mass and estimated breeding values for mass.
, 2017 (A): Year-specific mean mass corrected for age, sex, and date of measurement, with 95% CI. (B): Cohort-specific mean estimated breeding value for mass with their 95% CI, and the trend in breeding value with 95% CI.
Erik Postma (378595) +3 more
core +1 more source
Frontiers in Veterinary Science, 2020 The BVA/KC (British Veterinary Association/Kennel Club) and FCI (Fédération Cynologique Internationale) are the main screening schemes used to evaluate the status of canine hip dysplasia (HD) in Europe.
Shizhi Wang +4 more
doaj +1 more source
Molecular Oncology, EarlyView.Both cg12821679MAPRE3 methylation and MAPRE3 expression are significantly associated with overall survival (OS) of non‐small cell lung cancer. Meanwhile, MAPRE3 expression significantly modified the effect of smoking cessation on OS. Smoking cessation benefits OS merely for patients with high MAPRE3 expression.
Chao Chen +14 more
wiley +1 more source