Results 61 to 70 of about 1,268,202 (286)

Methods to Improve Joint Genetic Evaluation of Canine Hip Dysplasia Across BVA/KC and FCI Screening Schemes

Frontiers in Veterinary Science, 2020
The BVA/KC (British Veterinary Association/Kennel Club) and FCI (Fédération Cynologique Internationale) are the main screening schemes used to evaluate the status of canine hip dysplasia (HD) in Europe.
Shizhi Wang, Juliane Friedrich, Erling Strandberg, Per Arvelius, Pamela Wiener   +4 more
doaj   +1 more source

Breeding value prediction for production traits in layer chickens using pedigree or genomic relationships in a reduced animal model

Genetics Selection Evolution, 2011
BackgroundGenomic selection involves breeding value estimation of selection candidates based on high-density SNP genotypes. To quantify the potential benefit of genomic selection, accuracies of estimated breeding values (EBV) obtained with different ...
A. Wolc, C. Stricker, J. Arango, P. Settar, J. Fulton, N. O'sullivan, R. Preisinger, D. Habier, R. Fernando, D. Garrick, S. Lamont, J. Dekkers   +11 more
semanticscholar   +1 more source

Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer

Molecular Oncology, EarlyView.
COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann, Eduardo García‐Galea, Alice O'Farrell, Zak Kinsella, Maxime Meylan, Florent Petitprez, Ingrid Arijs, Tom Venken, Hari Ps, Adrian Lärkeryd, Ian Miller, Janick Selves, Nadja Meindl‐Beinker, Fiorella Ruiz‐Pace, Elena Élez, Raquel Comas‐Navarro, Frank Lincoln, Dirk Fey, Gift Nyamundanda, Aoife Nolan, Joern Lewin, Raquel Perez‐Lopez, Jonathan Briody, Kathleen Bennett, Walter Kolch, David Matallanas, Alexander Kel, Enrique Arenas, Joaquín Arribas, Bart Ghesquière, Josep Tabernero, Julie Meilleroux, Deborah McNamara, Ray McDermott, Marvin Lim, Mary O'Reilly, Brian Bird, Lisa Stack, Lucia Moloney, Patrick Morris, Keith Egan, Maciej Milewski, Lars Scheuer, Joachim Behringer, Georg Bolz, Ramon Salazar, Cristina Santos, Andrea Ruiz, Orla Casey, Verena Murphy, Matthias Ebert, Livio Trusolino, Diether Lambrechts, Anguraj Sadanandam, Catherine Sautès‐Fridman, Jochen Prehn, Paolo Nuciforo, Jacques Fieschi, Florence Monville, Darran O'Connor, Wolf Fridman, Annette Byrne   +61 more
wiley   +1 more source

Heritability in Plant Breeding on a Genotype-Difference Basis

Genetics, 2019
In plant breeding, heritability is often calculated (i) as a measure of precision of trials and/or (ii) to compute the response to selection. It is usually estimated on an entry-mean basis, since the phenotype is usually an aggregated value, as genotypes
Paul Schmidt, J. Hartung, J. Bennewitz, H. Piepho   +3 more
semanticscholar   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

ESTIMATED BREEDING V ALUES AND GENETIC TREND FOR MILK YIELD IN JERSEY COWS

Pakistan Veterinary Journal, 2003
Data on 1260 pedigree, breeding and performance records of 649 Jersey cattle maintaincd at Livestock Experiment Station Bhunikey (Pattoki) Distt. Kasur during the period 1982-2001 were utilized for the present study.
K. Javed, M. Atzal1 and R. H. Mirza
doaj  

Estimation of genomic breeding values using the Horseshoe prior [PDF]

BMC Proceedings, 2014
A method for estimating genomic breeding values (GEBV) based on the Horseshoe prior was introduced and used on the analysis of the 16(th) QTLMAS workshop dataset, which resembles three milk production traits. The method was compared with five commonly used methods: Bayes A, Bayes B, Bayes C, Bayesian Lasso and GLUP.The main difference between the ...
openaire   +3 more sources

Genomic breeding value prediction and QTL mapping of QTLMAS2010 data using Bayesian Methods

BMC Proceedings, 2011
BackgroundBayesian methods allow prediction of genomic breeding values (GEBVs) using high-density single nucleotide polymorphisms (SNPs) covering the whole genome with effective shrinkage of SNP effects using appropriate priors.
Xiaochen Sun, D. Habier, R. Fernando, D. Garrick, J. Dekkers   +4 more
semanticscholar   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Estimating Genetic Parameters to Enhance Brahman Cattle Performance in Indonesia

Tropical Animal Science Journal
Brahman cattle represent a critical resource for beef production in Indonesia, necessitating a comprehensive genetic improvement program to meet commercial demand and customer preferences.
A. Anang, H. Indrijani, M. H. Zulkarnaen
doaj   +1 more source