Results 151 to 160 of about 221,285 (352)

Evaluation of renal function and immune system cells in elderly individuals from São Paulo City

Clinics, 2013
OBJECTIVES: Both renal function and immune system function decline with age. Although controversial, a significant number of studies have shown that the decline in kidney function is associated with the worsening of the immune system.
Daniela Teixeira, leda Maria Longo-Maugeri, Yeda Aparecida Oliveira Duarte, Maria Lucia Lebrão, Valquiria Bueno   +4 more
doaj  

Evaluation of Renal Function in Obese Children and Adolescents Using Serum Cystatin C Levels, Estimated Glomerular Filtration Rate Formulae and Proteinuria: Which is most Useful?

, 2019
Dilşah Önerli Salman, Zeynep Şıklar, Nisa Eda Çullas İlarslan, Zeynep Birsin Özçakar, Pınar Kocaay, Merih Berberoğlu   +5 more
openalex   +1 more source

Changes in Dietary Nutrient Intake and Estimated Glomerular Filtration Rate over a 5-Year Period in Renal Transplant Recipients [PDF]

, 2023
I-Hsin Lin, Yi-Chun Chen, Tuyen Van Duong, Shih-Wei Nien, I-Hsin Tseng, Yiming Wu, Hsu-Han Wang, Yang‐Jen Chiang, Chia-Yu Chiang, Chia-Hui Chiu, Ming-Hsu Wang, Nien-Chieh Yang, Te-Chih Wong   +12 more
openalex   +1 more source

Incidence and Predictors of Hypoattenuated Thickening and Device‐Related Thrombus at Three Months Postprocedural CT Assessment Following Left Atrial Appendage Occlusion With Amplatzer Devices—A Single‐Center Cohort

Catheterization and Cardiovascular Interventions, EarlyView.
ABSTRACT Background Left atrial appendage occlusion (LAAO) has become a valuable alternative to long‐term anticoagulation for stroke prevention in patients with non‐valvular atrial fibrillation (AF), especially in those at high bleeding risk. Hypoattenuated thickening (HAT) and device‐related thrombus (DRT) remain notable postprocedural concerns ...
Pierre Guilleminot, Carole Richard, Antoine Roger, Marlène Daller, Gabriel Laurent, Catherine Vergely, Charles Guenancia, Thibaut Pommier   +7 more
wiley   +1 more source

Safety, Tolerability, Pharmacokinetics, Pharmacodynamics, and Food Effect of Bexicaserin in Healthy Participants: A First‐in‐Human Randomized, Double‐Blind, Placebo‐Controlled Single Ascending Dose Escalation Phase 1 Study

Clinical Pharmacology in Drug Development, EarlyView.
Abstract Bexicaserin (LP352) is a selective 5‐hydroxytryptamine 2C (5‐HT2C) superagonist in development for the treatment of seizures in developmental and epileptic encephalopathies (DEEs). This double‐blind, placebo‐controlled, single ascending dose (SAD) Phase 1 study aimed to assess the safety, tolerability, and pharmacokinetic (PK) and ...
Rosa Chan, Chad Orevillo, Gale O'Connell, Dewey McLin, Shikha Polega, Nuggehally R Srinivas, Randall Kaye   +6 more
wiley   +1 more source

Urological impact of race-free estimated glomerular filtration rate equations [PDF]

International Brazilian Journal of Urology
Natália Dalsenter Avilez, José Ignacio Nolazco, Steven Lee Chang, Leonardo O. Reis   +3 more
doaj   +1 more source

Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of Multiple Ascending Doses and Dose Titration of Bexicaserin in Healthy Participants in a Randomized, Double‐Blind, Placebo‐Controlled Study

Clinical Pharmacology in Drug Development, EarlyView.
Abstract Bexicaserin (LP352) is a selective superagonist of the 5‐hydroxytryptamine 2C (5‐HT2C) receptor currently in development for the treatment of seizures that arise from developmental and epileptic encephalopathies. This phase 1, double‐blind, placebo‐controlled multiple ascending dose (MAD) study assessed the safety, tolerability, and ...
Jonathan Williams, Rosa Chan, Chad Orevillo, Gale O'Connell, Dewey McLin, Shikha Polega, Nuggehally R. Srinivas, Randall Kaye   +7 more
wiley   +1 more source

Impact of Arteriovenous fistula creation on estimated glomerular filtration rate decline in Predialysis patients [PDF]

, 2019
Valérie Bénard, Maude Pichette, Jean‐Philippe Lafrance, Naoual Elftouh, Vincent Pichette, Louis‐Philippe Laurin, Annie‐Claire Nadeau‐Fredette   +6 more
openalex   +1 more source

Population Pharmacokinetics and Exposure–Response Analyses of Momelotinib, Its Active Metabolite (M21), and Total Active Moiety in Myelofibrosis

Clinical Pharmacology &Therapeutics, EarlyView.
Momelotinib, a Janus kinase (JAK) 1/JAK2/activin A receptor type 1 inhibitor, is approved for the treatment of myelofibrosis with anemia. These analyses characterized the population pharmacokinetics of momelotinib and its active metabolite M21 following administration of the commercial tablet formulation in patients with myelofibrosis from phase II/III
Benjamin Rich, Meenakshi Srinivasan, Yu Liu Ho, Sandra A.G. Visser, Geraldine Ferron‐Brady, Georgios Vlasakakis   +5 more
wiley   +1 more source

Lower estimated glomerular filtration rate relates to cognitive impairment and brain alterations

Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring
INTRODUCTION Chronic kidney disease (CKD) is associated with cognitive decline and changes in brain structure. However, their associations remain unclear, particularly the selective vulnerability characteristics that make some brain regions more ...
Shady Rahayel, Rémi Goupil, Dominique Suzanne Genest, Florence Lamarche, Mohsen Agharazii, Violette Ayral, Christina Tremblay, François Madore   +7 more
doaj   +1 more source