Results 71 to 80 of about 6,936,552 (305)

USP30‐Mediated Deubiquitination of PEX5 Suppresses Pexophagy to Drive Tubular Injury in Diabetic Kidney Disease

Advanced Science, EarlyView.
USP30 accumulation in diabetic renal tubular epithelial cells deubiquitinates PEX5, suppresses pexophagy, and drives dysfunctional peroxisome accumulation and tubular injury. USP30 depletion restores PEX5 ubiquitination and pexophagy, improves peroxisomal function, and alleviates tubular damage, highlighting USP30 as a therapeutic target in diabetic ...
Jia Li, Chaoyang Hua, Guangpu Li, Furong Zhai, Jingjing Ren, Shaokang Pan, Qi Feng, Jianguo Wen, Dongwei Liu, Zhangsuo Liu, Jiayu Duan   +10 more
wiley   +1 more source

Serum uric acid and albumin levels and estimated glomerular filtration rate: Oxidative stress considerations

, 2012
Uric acid has both antioxidant and oxidant properties, is excreted by the kidney and is associated with development of kidney disease. Albumin, another antioxidant is also excreted by the kidney in some renal diseases.
Ruven, Henk, Nielsen, Sharon, Kalle, Wouter, Butkowski, Eugene, Nwose, Uba, Bwititi, Phillip, Richards, Ross   +6 more
core   +1 more source

Estimated glomerular filtration rate and drug dose adjustment in patients in an intensive care unit in Brazil

Brazilian Journal of Pharmaceutical Sciences, 2020
Objectives. This study sought to compare the estimated glomerular filtration rate and the indication of dose adjustment of antimicrobials when using Cockcroft-Gault or Modification of Diet in Renal Disease. Methods.
Marianne Silveira Camargo, Márcio Galvão Oliveira, Sostenes Mistro, Izabel Cristina Pereira Rocha, Camila Neto Santos, Caroline Tianeze de Castro, Luiz Carlos Santana Passos   +6 more
doaj   +1 more source

Estimated glomerular filtration rate equations.

, 2015
Ideal body weight was calculated using the formula by Devine (34) with height measured in centimeters. In the Salazar-Corcoran equation, weight is expressed in kilogram and height in meter.Scr = serum creatinine, AWB = actual body weight, IBW = ideal ...
Ahmed Solomon (540006), Patrick H. Dessein (540002), Miguel A. Gonzalez-Gay (5662702), Angela J. Woodiwiss (540005), Aletta M. E. Millen (712099), Gavin R. Norton (540004), Linda Tsang (540003), Hon-Chun Hsu (712098)   +7 more
core   +1 more source

SPARC Drives Podocyte Mitochondrial Damage and Ferroptosis in Diabetic Kidney Disease Following Klotho Deficiency

Advanced Science, EarlyView.
Klotho deficiency promotes podocyte mitochondrial dysfunction and ferroptosis through activation of the PKCα/CUX1/SPARC/TGFβ‐RII axis. SPARC emerges as a key mediator linking Klotho loss to podocyte injury in DKD and other kidney injury models, suggesting broader implications for CKD progression.
Qing Yang, Huimin Jiang, Chenyang Xiong, Xindi Zhou, Qinqin Tan, Han Xiao, Lan Qiu, Chun Gan, Yaxi Chen, Haiping Yang, Wei Jiang, Qiu Li   +11 more
wiley   +1 more source

The Impact of Reporting Estimated Glomerular Filtration Rate

Renal Failure, 2011
The 'Kidney Disease Outcomes Quality Initiative' guidelines recommend laboratory reporting of a calculated estimated glomerular filtration rate (eGFR). The United Kingdom and several states already mandate reporting eGFR for every laboratory serum creatinine (sCr) measurement. In our study, we evaluated the impact of reporting eGFR on the management of
Abdallah Sassine, Geara, Nadine, Azzi, Pratima, Ghimire, Marie, Abdallah, Ayesha, Siddiqui, Claude, Bassil, Suzanne, El-Sayegh   +6 more
openaire   +2 more sources

Renal Function - Estimation of Glomerular Filtration Rate [PDF]

Journal of Medical Biochemistry, 2007
Funkcija Bubrega - Procena Brzine Glomerularne Filtracije Brzina glomerularne filtracije (GFR) je široko prihvaćena kao najbolja opšta mera funkcije bubrega. Vodiči američke Nacionalne fondacije za bubreg definišu hroničnu bubrežnu bolest (HBB) bilo sa vrednošću GFR koja je manja od 60 mL/min/1,73 m2 ili sa prisustvom oštećenja bubrega, bez ...
Dajak, Marijana, Ignjatović, Svetlana, Majkić-Singh, Nada   +2 more
openaire   +2 more sources

Gut Microbiota‐Isoallolithocholic Acid Crosstalk Promotes Calcium Oxalate Kidney Stone Formation via PARP1‐Mediated Parthanatos

Advanced Science, EarlyView.
ABSTRACT Bile acids have been implicated in calcium oxalate (CaOx) nephrolithiasis. Here, we employ multi‐omics approaches to identify isoallolithocholic acid (isoalloLCA) as the key bile acid elevated in the feces, serum, kidney, and urine of CaOx rats, confirmed by spatial metabolomics.
Zijian Zhou, Ruixi Yu, Xuan Zhou, Feng Shi, Zeyu Lin, Peng Gao, Lujia Wang, Ninghan Feng, Zhong Wu, Dawei Wang   +9 more
wiley   +1 more source

Microalbuminuria in normotensive nondiabetic overweight and obese versus nonobese adults

Journal of Family Medicine and Primary Care
Introduction: Obesity has reached an epidemic stage worldwide. As the prevalence of obesity increases, the burden of its associated comorbidities increases.
Kiran, Madhubala Negi
doaj   +1 more source

Impact of estimated glomerular filtration rate on long-term clinical outcomes among Chinese patients with atrial fibrillation

BMC Cardiovascular Disorders, 2020
Background Estimated glomerular filtration rate (eGFR) is a widely accepted indicator of renal function. The aim of this study was to evaluate the relationship between eGFR and 3-year clinical outcomes among Chinese patients with atrial fibrillation (AF).
Huaibin Wan, Juan Wang, Yanmin Yang, Xin Fan, Dongdong Chen, Ning Bian   +5 more
doaj   +1 more source