Results 81 to 90 of about 2,627,208 (304)
Robust Estimation of Mean Values
CoRR, 2008 In this paper, we develop a computational approach for estimating the mean value of a quantity in the presence of uncertainty. We demonstrate that, under some mild assumptions, the upper and lower bounds of the mean value are efficiently computable via a sample reuse technique, of which the computational complexity is shown to posses a Poisson ...
openaire +2 more sources
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers
Molecular Oncology, EarlyView.The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce +11 more
wiley +1 more source
AnimalsThe aim of this study was to identify SNPs in the cattle genome associated with estimated breeding values of feet (EBVfeet) in Holstein-Friesian (HF) cows in Hungary.
Attila Zsolnai +6 more
doaj +1 more source
Distribution of estimated posterior probabilities that a P-value is a false finding.
, 2016 Color refers to whether the actual signal is genuine (red) or false (blue). Purple color denotes the overlap of genuine and false signals. First graph: Estimated probability that the smallest P-value in a scan (minP) is a false finding.
Olga A. Vsevolozhskaya (632441) +2 more
core +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Post lung-transplant predictive value of thermodilution vs estimated Fick cardiac output measurement
JHLT OpenBackground: Comparison of thermodilution (TD) and indirect Fick (iFick) methods of cardiac output (CO) measurement has not been well described in patients with World Health Organization (WHO) group 3 pulmonary hypertension (PH).
Jose Rivera-Robles, MD +7 more
doaj +1 more source
The value of a statistical life for out-of-hospital cardiac arrest victims [PDF]
Background: Economic evaluation of policies regarding out-of-hospital cardiac arrest (OHCA) is important and we estimate the value of a statistical life (VSL) for OHCA victims.
Sund, Björn
core
Molecular Oncology, EarlyView.In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge +17 more
wiley +1 more source