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Reduce computation in profile empirical likelihood method [PDF]

Since its introduction by Owen in [29, 30], the empirical likelihood method has been extensively investigated and widely used to construct confidence regions and to test hypotheses in the literature.
Li, Minqiang, Peng, Liang, Qi, Yongcheng
core   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

YIPFα1A expression is regulated by multilayered molecular mechanisms

FEBS Open Bio, EarlyView.
YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji, Yurika Nakanishi, Nobuhiro Nakamura   +2 more
wiley   +1 more source

Omitting patients with no follow-up leads to bias when using inverse-intensity weighted GEEs to handle irregular and informative assessment times

BMC Medical Research Methodology
Background Longitudinal data can be used to study disease progression and are often collected at irregular intervals. When the assessment times are informative about the severity of the disease, regression analyses of the outcome trajectory over time ...
Xiawen Zhang, Anna Heath, Wei Xu, Eleanor Pullenayegum   +3 more
doaj   +1 more source

Growth of Meromorphic Function Sharing Functions and Some Uniqueness Problems

Journal of Function Spaces, 2016
Estimating the growth of meromorphic solutions has been an important topic of research in complex differential equations. In this paper, we devoted to considering uniqueness problems by estimating the growth of meromorphic functions.
Jianming Qi, Fanning Meng, Wenjun Yuan
doaj   +1 more source

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

FEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young, Omar Arias‐Gaguancela, Fiona Gibson, Morgan Grainger, Jodie Score, Amit Nathubhai, Mauricio Cafiero, Lee Richard Machado   +7 more
wiley   +1 more source

%QLS SAS Macro: A SAS Macro for Analysis of Correlated Data Using Quasi-Least Squares

Journal of Statistical Software, 2010
Quasi-least squares (QLS) is an alternative computational approach for estimation of the correlation parameter in the framework of generalized estimating equations (GEE). QLS overcomes some limitations of GEE that were discussed in Crowder (1995).
Han-Joo Kim, Justine Shults
doaj  

Data acquisition varies by bat phonic group for 2 types of bat detectors when weatherproofed and paired in field settings

Wildlife Society Bulletin, 2015
Manufacturers of acoustic bat detectors use proprietary microphones with different frequency responses, sensitivities, and directionality. Researchers implement various waterproofing strategies to protect microphones from inclement weather. These factors
Zachary D. E. Kaiser, Joy M. O'Keefe
doaj   +1 more source

Evaluation of Initial Shear Stiffness Empirical Models for Unsaturated Soils with In-situ Down-Hole Tests [PDF]

مدل‌سازی پیشرفته در مهندسی عمران
Initial shear stiffness is one of the critical parameters in geotechnical investigations. It mainly applies to evaluating the seismic ground response analysis and the seismic design of earthen structures.
Mahdi Abedinezhad, Mahnoosh Biglari, Iman Ashayeri   +2 more
doaj   +1 more source

Higher Order Estimating Equations for High-dimensional Models

, 2015
We introduce a new method of estimation of parameters in semiparametric and nonparametric models. The method is based on estimating equations that are $U$-statistics in the observations.
Li, Lingling, Mukherjee, Rajarshi, Robins, James, Tchetgen, Eric Tchetgen, van der Vaart, Aad   +4 more
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