Results 101 to 110 of about 166,390 (310)

Testing for bias in weighted estimating equations

, 2001
It is very common in regression analysis to encounter incompletely observed covariate information. A recent approach to analyse such data is weighted estimating equations (Robins, J. M., Rotnitzky, A. and Zhao, L. P.
Lipsitz, Stuart, Molenberghs, Geert, Ibrahim, J., Lipsitz, S., Ibrahim, Joseph G., Parzen, M., Parzen, Michael   +6 more
core   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

EM Algorithm for Estimating Equations [PDF]

, 1998
15 pages, 1 article*EM Algorithm for Estimating Equations* (Casella, George; Ohman, Pamela A.) 15 ...
Casella, George, Cornell University. Dept. of Biological Statistics and Computational Biology., Cornell University. Biometrics Unit., Ohman, Pamela A., Cornell University. Dept. of Biometrics.   +4 more
core  

Liquid biopsy‐based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis

Molecular Oncology, EarlyView.
This schematic outlines the workflow from biomarker identification to duplex MethyLight assay validation for epithelial ovarian cancer diagnosis using cfDNA‐based liquid biopsy. Initial screening of hypermethylated CpG candidates (cg02957270, cg10061138 cg00480298, COL2A1) was performed in tissue using ARMS‐PCR, COBRA, qPCR and image analysis. Selected
Deepa Bisht, Sameer Gupta, Amrita Chaurasia, Manisha Sachan   +3 more
wiley   +1 more source

Univariable and multivariable generalized estimating equations analysis.

, 2019
Univariable and multivariable generalized estimating equations analysis.
Michael Ip (6392399), Marco Nassisi (5979575), Enrico Borrelli (750198), Elmira Baghdasaryan (5979578), Srinivas R. Sadda (520589)   +4 more
core   +1 more source

Patient therapy outcome modeling in cancer organoids is improved by cancer‐associated fibroblasts and organoid assembly convolution

Molecular Oncology, EarlyView.
Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski, Liudmyla Dolinchuk, Michał Jerzak, Albert Gandurski, Tomasz Grochowski, Weronika Wojtyś, Maciej Zadrożny, Wojciech Kaźmierczak, Małgorzata Lenarcik, Marta Matejak‐Górska, Radosław Samsel, Tomasz Olesiński, Dawid Walerych   +12 more
wiley   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Promiscuous stimulation of HSP70 ATPase activity by parasite‐derived J‐domains

FEBS Open Bio, EarlyView.
The malaria parasite Plasmodium falciparum exports three highly homologous yet functionally divergent J‐domain proteins into human erythrocytes. Here, we show that J‐domains isolated from all three proteins effectively stimulate the ATPase activity of both endogenous host and exported parasite HSP70 chaperones.
Julian Barth, Moritz Koch, Le‐Han Rössner, Johanna Eichhorn, Denys Pogoryelov, Matthias P. Mayer, Jude M. Przyborski   +6 more
wiley   +1 more source

Short-term changes in bodily pain and associated baseline factors in patients with fibromyalgia receiving paraprobiotic supplementation: a retrospective observational study

Frontiers in Medicine
BackgroundFibromyalgia is characterized by heterogeneous pain trajectories, and short-term clinical improvement may vary across patients. We explored whether routinely collected baseline clinical variables were associated with short-term bodily pain ...
David Castro Corredor, David Castro Corredor, Luis Ángel Calvo Pascual, Luis Ángel Calvo Pascual, Luis Ángel Calvo Pascual, María B. García-Moreno García   +5 more
doaj   +1 more source

Growth of Meromorphic Function Sharing Functions and Some Uniqueness Problems

Journal of Function Spaces, 2016
Estimating the growth of meromorphic solutions has been an important topic of research in complex differential equations. In this paper, we devoted to considering uniqueness problems by estimating the growth of meromorphic functions.
Jianming Qi, Fanning Meng, Wenjun Yuan
doaj   +1 more source