Results 61 to 70 of about 5,561,714 (285)

Application pratique de la méthode d’estimation de l’âge au décès de Schmitt et Broqua (2000)

Bulletins et Mémoires de la Société d’Anthropologie de Paris, 2004
Cette étude tend à confronter la méthode d’estimation de l’âge au décès proposée par Schmitt et Broqua (2000) à la réalité archéologique de la population d’une nécropole historique. Le grand nombre de bassins étudiés (940) permet une approche statistique
Ludovic Debono, Bertrand Mafart, Gaspard Guipert, Élise Jeusel   +3 more
doaj   +1 more source

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

Computer vision uncovers three fundamental dimensions of levodopa-responsive motor improvement in Parkinson’s disease

npj Parkinson's Disease
We developed VisionMD, an AI computer vision platform, analyzing over 1200 clinical videos of Parkinson’s patients’ hand movements across 13 years. This large-scale, markerless analysis identified three kinematic domains (speed, consistency, timing/scale)
Florian Lange, Diego L. Guarin, Esther Ademola, Dalia Mahdy, Gabriela Acevedo, Thorsten Odorfer, Joshua K. Wong, Jens Volkmann, Robert Peach, Martin Reich   +9 more
doaj   +1 more source

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

FEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva, Puspa Kunwar, Md Ibnul Rifat Rahman, Joanna Koryo Kwao, Nathan Lehman, Zihan Zhang, Trenton Paul, Claire Cheng, Nicholas Truex, Hui‐Ting Lee, Jun Zhang   +10 more
wiley   +1 more source

Second-Order Fault Tolerant Extended Kalman Filter for Discrete Time Nonlinear Systems [PDF]

, 2019
As missing sensor data may severely degrade the overall system performance and stability, reliable state estimation is of great importance in modern data-intensive control, computing, and power systems applications.
Wang, Xin, Yaz, Edwin E.
core   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Mapping heterogeneity in family planning indicators in Burkina Faso, Kenya, and Nigeria, 2000–2020

BMC Medicine
Background Family planning is fundamental to women’s reproductive health and is a basic human right. Global targets such as Sustainable Development Goal 3 (specifically, Target 3.7) have been established to promote universal access to sexual and ...
GBD Local and Small Area Estimation Family Planning Collaborators
doaj   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Remote sensing-based estimation of precipitation data (2000-2015) in Ecuador's Loja province

Frontiers in Environmental Science
The primary climatic parameter frequently scrutinized in water balance assessments for water utilization is precipitation. Given its considerable variability across locations and over time, it is imperative to rely on high-quality statistical information
Luis Valverde, César Iván Álvarez, Dayana Gualotuña   +2 more
doaj   +1 more source