Results 61 to 70 of about 215,550 (310)
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Cross-correlation of output fluctuation and system-balancing cost in photovoltaic integration
The Journal of Engineering, 2014 The authors analysed the cross-correlation of photovoltaic (PV) output fluctuation for the actual PV output time series data in both the Tokyo area and the whole of Japan using the principal component analysis with the random matrix theory.
Yuichi Ikeda, Kazuhiko Ogimoto
doaj +1 more source
LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro
Molecular Oncology, EarlyView.Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix +13 more
wiley +1 more source
Optomechanics-Based Quantum Estimation Theory for Collapse Models. [PDF]
Entropy (Basel), 2023 Marchese MM, Belenchia A, Paternostro M.
europepmc +1 more source
Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity
Molecular Oncology, EarlyView.Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung +17 more
wiley +1 more source
Optimization of data acquisition operation in optical tomography based on estimation theory. [PDF]
Biomed Opt Express, 2021 Javidan M, Esfandi H, Pashaie R.
europepmc +1 more source
Molecular Oncology, EarlyView.This study shows that copy number variations (CNVs) can be reliably detected in formalin‐fixed paraffin‐embedded (FFPE) solid cancer samples using ultra‐low‐pass whole‐genome sequencing, provided that key (pre)‐analytical parameters are optimized.
Hanne Goris +10 more
wiley +1 more source
Multithreshold change plane model: Estimation theory and applications in subgroup identification. [PDF]
Stat Med, 2021 Li J, Li Y, Jin B, Kosorok MR.
europepmc +1 more source
Molecular Oncology, EarlyView.Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon +9 more
wiley +1 more source
Modified CRLB Based Optimal Sampling Frequency Selection in Phase and Frequency Estimation
IEEE Access, 2019 The sampling process is an almost indispensable operation in signal processing. The sampling frequency is one of the factors in the sampling process and the selection of it is also important in the signal processing issues, such as detection, estimation,
Hao Wu, Yongqiang Cheng, Hongqiang Wang
doaj +1 more source