Results 251 to 260 of about 309,036 (359)

Estradiol deficiency as a consequence of aging contributes to the depletion of the satellite cell pool in female mice

open access: yesAging Cell, Volume 24, Issue 4, April 2025.
In females, estradiol deficiency is a major environmental factor contributing to the age‐associated effects on satellite cells. To assess cell‐intrinsic versus environmental regulation of satellite cells, we perform two transplantation experiments, Adult or Aged satellite cells transplanted into Adult recipients, and Adult satellite cells transplanted ...
Brian P. Sullivan   +7 more
wiley   +1 more source

DeepQA: A Unified Transcriptome‐Based Aging Clock Using Deep Neural Networks

open access: yesAging Cell, Volume 24, Issue 5, May 2025.
DeepQA, a unified aging clock based on mixture of experts which is trained on both healthy and unhealthy subjects. ABSTRACT Understanding the complex biological process of aging is of great value, especially as it can help develop therapeutics to prolong healthy life.
Hongqian Qi   +6 more
wiley   +1 more source

GnRH-agonist implants suppress reproductive function and affects ovarian LHR and FSHR expression in prepubertal female cats [PDF]

open access: yes, 2017
Axner   +34 more
core   +1 more source

Incorporating familial risk, lifestyle factors, and pharmacogenomic insights into personalized noncommunicable disease (NCD) reports for healthcare funder beneficiaries participating in the Open Genome Project

open access: yesAnnals of Human Genetics, EarlyView.
Abstract Introduction An ethics‐guided decision‐making framework was developed for applying pathology‐supported genetic testing, a multifaceted pharmacodiagnostic approach that translates population risk stratification into clinical utility. We introduce this service, supported by the Open Genome Project, which aligns with the beneficence principle in ...
Manie De Klerk   +6 more
wiley   +1 more source

Vaginoscopy to investigate vaginal bleeding and discharge in prepubertal girls

open access: yesAustralian and New Zealand Journal of Obstetrics and Gynaecology, Volume 65, Issue 1, Page 140-146, February 2025.
Study Objective To investigate the aetiology of vaginal bleeding and discharge in prepubescent girls, and the utility of vaginoscopy for making a diagnosis. Design Retrospective observational study over 14 years. Setting Two major tertiary referral paediatric hospitals in Sydney, Australia.
Asha Short   +4 more
wiley   +1 more source

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