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Best Practice & Research Clinical Endocrinology & Metabolism, 2016
Ovarian steroids, such as estradiol (E2), control a vastness of physiological processes, such as puberty, reproduction, growth, development and metabolic rate. In fact, physiological, pathological, pharmacological or genetically-induced estrogen deficiency causes increased appetite and reduced energy expenditure, promoting weight gain and ultimately ...
Manuel Tena-Sempere +2 more
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Ovarian steroids, such as estradiol (E2), control a vastness of physiological processes, such as puberty, reproduction, growth, development and metabolic rate. In fact, physiological, pathological, pharmacological or genetically-induced estrogen deficiency causes increased appetite and reduced energy expenditure, promoting weight gain and ultimately ...
Manuel Tena-Sempere +2 more
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Synthesis of [2‐d]estradiol, [4‐d]estradiol, [2‐t]estradiol and [4‐t]estradiol with high specificity
Journal of Labelled Compounds and Radiopharmaceuticals, 1984Abstract17‐β‐Estradiol has been labeled in the 2 or 4 position with tritium or deuterium. Both 2‐ and 4‐iodoestradiol were prepared by treatment of estradiol with N‐iodosuccinimide in ethanol followed by chromatographic separation. Reductive dehalogenation of 2‐ and 4‐iodoestradiol with tritium gas gave [2‐t] estradiol and [4‐t] estradiol, respectively,
Mont R. Juchau +3 more
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The Effect of Mercury Estradiol on 17β-Estradiol Dehydrogenase
Gynecologic and Obstetric Investigation, 1970The effects of two organic mercurials (4-acetatomercuri-17Β-estradiol and <i>p</i>-chloromercuribenzoate) on human placental estradiol dehydrogenase were evaluated by equilibrium rate exchange and initial velocity measurements. The steroid mercurial was more effective in reducing isotopic exchange between steroid pairs than between
G. Betz, P. Susee
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An Alternative Route to 2-Bromo-Estradiols and 2-Iodo-Estradiols From Estradiol
Australian Journal of Chemistry, 1987Through careful choice of reaction conditions, alkylation of estradiol with chloromethyl methyl ether may yield either the 3,17β-bis(methoxymethy1) ether or the 3-methoxymethyl ether derivative. Treatment of either of these protected estradiols with s- butyllithium, then with trimethylsilyl chloride affords, regioselectively, the 2-trimethylsilyl
DD Ridley, DJ Pert
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17-α-estradiol and 17-β-estradiol in hippocampus
Brain Research Bulletin, 1983Electrophysiological field potentials recorded from in vitro hippocampal slice preparations show responses to exogenous gonadal steroids added to the incubation medium. The peak effect of the addition of 17-beta-estradiol occurred at a 100 pmol concentration; the CA1 field potential was increased by an average of 148 percent.
Timothy J. Teyler, Michael R. Foy
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The Clearance and Metabolism of Estradiol and Estradiol-17-Esters in the Rat*
Endocrinology, 1985The C-17 fatty acid esters of estradiol are naturally occurring estrogens which have been shown to circulate in blood. They are long-acting estrogens, analogous to the synthetic alkyl and aryl esters of estrogens which have been used pharmacologically for decades.
Richard B. Hochberg, Janice M. Larner
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Drugs, 2002
Estradiol valerate 2mg/dienogest 2mg is an oral estrogen/ progestogen formulation that has been approved throughout the European Union for the treatment of climacteric symptoms in postmenopausal women. Dienogest is a progestogen that combines the properties of both progesterone and 19-nortestosterone derivatives.
Keri Wellington, Caroline M. Perry
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Estradiol valerate 2mg/dienogest 2mg is an oral estrogen/ progestogen formulation that has been approved throughout the European Union for the treatment of climacteric symptoms in postmenopausal women. Dienogest is a progestogen that combines the properties of both progesterone and 19-nortestosterone derivatives.
Keri Wellington, Caroline M. Perry
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Drospirenone/ethinyl estradiol
Drugs of Today, 2008Drospirenone 3 mg/ethinyl estradiol 20 microg (24/4) is a new unique oral contraceptive formulation that combines in a novel dosing regimen the lowest dosage of ethinyl estradiol commonly used today with drospirenone, an innovative progestin.
Shelley N. Sorger +2 more
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Genotoxicity evaluation of estradiol
Mutation Research/Genetic Toxicology, 1995Abstract Genotoxic evaluation of estradiol, a commonly used estrogen, was undertaken using various short-term in vitro and in vivo assays. The clastogenic potential of estradiol was evident from the chromosome aberrations and sister chromatid exchanges induced by it both without and with metabolic activation in cultured human lymphocytes and also ...
Varinderpal S. Dhillon +1 more
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The thermal degradation of estradiol
Biochimica et Biophysica Acta, 1962Abstract Thermal degradation of purified estradiol between 275 and 375° was found to be a series of low-yield first-order reactions. Up to 317° estrone and hydrogen were identified as residual molecular fragments. Evidence for further dehydrogenations and possible dehydration was also obtained.
Horace F. Martin, Herbert H. Wotiz
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