Results 261 to 270 of about 345,140 (332)

Estrogen Production in Pancreatic Cancer Shapes a Tumor-Suppressive Stromal Microenvironment. [PDF]

Cancer Res
Manoukian P, van Schie DM, van Schelt AS, Wassenaar NPM, Dings MPG, Lansbergen MF, Waasdorp C, Leite de Oliveira R, Wickenhagen WV, Heijboer AC, Koster J, Zwijnenburg DA, Farina-Sarasqueta A, Kazemier G, Wilmink JW, Medema JP, van Laarhoven HWM, Bijlsma MF.   +17 more
europepmc   +1 more source

TRPM3 activation causes CGRP release in trigeminal neurons: Implications for migraine mechanisms

Headache: The Journal of Head and Face Pain, EarlyView.
Abstract Background The transient receptor potential melastatin 3 (TRPM3) ion channel has been implicated in sensory modulation and pain transmission and may contribute to migraine pathophysiology through calcitonin gene‐related peptide (CGRP) release in the trigeminovascular system. This study aimed to investigate TRPM3 activation and its role in CGRP
Philip V. Reducha, Lukas K. S. Nielsen, Mette N. Jensen, Jacob C. A. Edvinsson, Spyridoula Kazantzi, Sofia L. Wæver, Tanja Lylloff, Connar S. J. Westgate, Lars Edvinsson, Kristian A. Haanes   +9 more
wiley   +1 more source

Neuroinflammation and the Female Brain: Sex-Specific Mechanisms Underlying Mood Disorders and Stress Vulnerability. [PDF]

Life (Basel)
Marano G, d'Abate C, Traversi G, Mazza O, Gaetani E, Esposito R, Pavese F, Paris I, Mazza M.   +8 more
europepmc   +1 more source

Exploring the impact of Cabotegravir‐Rilpivirine long‐acting on weight gain, body composition and quality of life in adults living with HIV

HIV Medicine, EarlyView.
Abstract Introduction Long‐acting injectable antiretroviral therapy (ART) with Cabotegravir (CAB) and Rilpivirine (RPV) offers an alternative to daily oral regimens, improving adherence and patient satisfaction. However, its impact on body composition and metabolism remains underexplored.
Andrea De Vito, Andrea Marongiu, Antonella Cano, Mariangela Puci, Agnese Colpani, Susanna Maria Nuvoli, Maria Grazia Catte, Giulia Moi, Maria Antonietta Deledda, Sergio Uzzau, Giovanni Sotgiu, Franca Deriu, Angela Spanu, Giordano Madeddu   +13 more
wiley   +1 more source

Evaluating the Reproductive Impact of Pembrolizumab in Mice: Ovarian Function and Hormonal Changes. [PDF]

In Vivo
Sütcüoğlu BM, Sütcüoğlu O, Öğüt B, Akdoğan O, Kodaz ÇE, Yilmaz C, Erdem Ö, Anadol E, Özdemir N.   +8 more
europepmc   +1 more source

The exposomal imprint on rosacea: More than skin deep

Journal of the European Academy of Dermatology and Venereology, EarlyView.
Rosacea reflects systemic and environmental interactions, not just a skin disorder. Key factors include environmental triggers, genetic and microbiome influences, diagnostic gaps in skin of colour and social determinants. Advances in multi‐omics and exposome integration highlight pathways towards precision medicine, prevention and equitable, patient ...
Katerina Grafanaki, Daniella Bakoli Sgourou, Alexandros Maniatis, Efstathia Pasmatzi   +3 more
wiley   +1 more source

Community science datasets identify the spatial occurrence and hotspots of flapper skate (Dipturus intermedius)

Journal of Fish Biology, EarlyView.
Abstract The flapper skate, Dipturus intermedius (Parnell, 1837), is a large‐bodied, slow‐growing and late‐maturing, Critically Endangered elasmobranch with a constrained population distribution. Here, we use two longitudinal community science datasets to investigate the occurrence of flapper skates in Irish waters. The two datasets are as follows: the
Danielle L. Orrell, Ciara Wögerbauer, Shane O'Reilly, Thomas K. Doyle, William Roche   +4 more
wiley   +1 more source

Deciphering the complex life cycle and partial migration of an ecological engineer and critical Neotropical fishery species, Prochilodus costatus

Journal of Fish Biology, EarlyView.
Abstract Understanding complex migration patterns, including drivers of partial migration and habitat use, is challenging but essential for conservation, as it determines a species' adaptative capacity in the face of environmental change and anthropogenic threats.
Alexandre Peressin, João de Magalhães Lopes, Francisco Ricardo Andrade Neto, Gilmara Junqueira Machado, Carlos Bernardo Mascarenhas Alves, Luis David Solis Murgas, Paulo Santos Pompeu   +6 more
wiley   +1 more source

Estradiol trajectories and early pregnancy loss: a retrospective study. [PDF]

Front Endocrinol (Lausanne)
Wei Y, Wei X, Mu F, Wang F.
europepmc   +1 more source