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The Effect of Mercury Estradiol on 17β-Estradiol Dehydrogenase
Gynecologic and Obstetric Investigation, 1970The effects of two organic mercurials (4-acetatomercuri-17Β-estradiol and <i>p</i>-chloromercuribenzoate) on human placental estradiol dehydrogenase were evaluated by equilibrium rate exchange and initial velocity measurements. The steroid mercurial was more effective in reducing isotopic exchange between steroid pairs than between
G. Betz, P. Susee
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17-α-estradiol and 17-β-estradiol in hippocampus
Brain Research Bulletin, 1983Electrophysiological field potentials recorded from in vitro hippocampal slice preparations show responses to exogenous gonadal steroids added to the incubation medium. The peak effect of the addition of 17-beta-estradiol occurred at a 100 pmol concentration; the CA1 field potential was increased by an average of 148 percent.
Timothy J. Teyler, Michael R. Foy
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The Clearance and Metabolism of Estradiol and Estradiol-17-Esters in the Rat*
Endocrinology, 1985The C-17 fatty acid esters of estradiol are naturally occurring estrogens which have been shown to circulate in blood. They are long-acting estrogens, analogous to the synthetic alkyl and aryl esters of estrogens which have been used pharmacologically for decades.
Richard B. Hochberg, Janice M. Larner
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Drugs, 2002
Estradiol valerate 2mg/dienogest 2mg is an oral estrogen/ progestogen formulation that has been approved throughout the European Union for the treatment of climacteric symptoms in postmenopausal women. Dienogest is a progestogen that combines the properties of both progesterone and 19-nortestosterone derivatives.
Keri Wellington, Caroline M. Perry
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Estradiol valerate 2mg/dienogest 2mg is an oral estrogen/ progestogen formulation that has been approved throughout the European Union for the treatment of climacteric symptoms in postmenopausal women. Dienogest is a progestogen that combines the properties of both progesterone and 19-nortestosterone derivatives.
Keri Wellington, Caroline M. Perry
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Drospirenone/ethinyl estradiol
Drugs of Today, 2008Drospirenone 3 mg/ethinyl estradiol 20 microg (24/4) is a new unique oral contraceptive formulation that combines in a novel dosing regimen the lowest dosage of ethinyl estradiol commonly used today with drospirenone, an innovative progestin.
Shelley N. Sorger +2 more
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Genotoxicity evaluation of estradiol
Mutation Research/Genetic Toxicology, 1995Abstract Genotoxic evaluation of estradiol, a commonly used estrogen, was undertaken using various short-term in vitro and in vivo assays. The clastogenic potential of estradiol was evident from the chromosome aberrations and sister chromatid exchanges induced by it both without and with metabolic activation in cultured human lymphocytes and also ...
Varinderpal S. Dhillon +1 more
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The thermal degradation of estradiol
Biochimica et Biophysica Acta, 1962Abstract Thermal degradation of purified estradiol between 275 and 375° was found to be a series of low-yield first-order reactions. Up to 317° estrone and hydrogen were identified as residual molecular fragments. Evidence for further dehydrogenations and possible dehydration was also obtained.
Horace F. Martin, Herbert H. Wotiz
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Fertility and Sterility, 1988
Serum estradiol (E2) levels were measured in 451 men attending an infertility clinic and 80 fertile men attending for vasectomy. The normal range of E2 levels found in fertile men was 70 to 200 pmol/l. Subfertile men had lower mean E2 levels than fertile men (P less than 0.05), but there was no relationship to obesity, cigarette smoking, age, or the ...
Timothy B. Hargreave +3 more
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Serum estradiol (E2) levels were measured in 451 men attending an infertility clinic and 80 fertile men attending for vasectomy. The normal range of E2 levels found in fertile men was 70 to 200 pmol/l. Subfertile men had lower mean E2 levels than fertile men (P less than 0.05), but there was no relationship to obesity, cigarette smoking, age, or the ...
Timothy B. Hargreave +3 more
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Estradiol regulation of uterine nucleolar estradiol binding sites
Biochimica et Biophysica Acta (BBA) - General Subjects, 1986Rat uterine nuclei contain two types of estrogen binding sites (I and II). Type I is the classical high-affinity, low-capacity binding component, while Type II has lower affinity and higher capacity. Investigation of the presence and number of estrogen-binding proteins in isolated uterine nucleoli, and the possible role of the estrogen-binding protein ...
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Copper and the estradiol receptor
Biochemical and Biophysical Research Communications, 1987Copper is an essential element in living organisms and it appears to be involved in estrogen action. This study bears on the manner in which the metal may be linked to the mechanism of this action. Divalent copper was found to induce at 37 degrees C a several fold increase in estradiol binding to the receptors in rat uterine cytosols.
Jack Fishman, Jerry H. Fishman
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