Results 81 to 90 of about 213,022 (296)

Tamoxifen: an FDA approved drug with neuroprotective effects for spinal cord injury recovery

Neural Regeneration Research, 2016
Spinal cord injury (SCI) is a condition without a cure, affecting sensory and/or motor functions. The physical trauma to the spinal cord initiates a cascade of molecular and cellular events that generates a non-permissive environment for cell survival ...
Jennifer M Colón, Jorge D Miranda
doaj   +1 more source

TP53 Loss Elevates NF‐κB‐IFN‐β‐MHC‐Ia Signaling to Promote NK Cell Resistance in Osteosarcoma

Advanced Science, EarlyView.
TP53 loss in a transforming or osteosarcoma cell promotes cytosolic DNA accumulation, activating NF‐κB‐dependent IFN‐β production. Autocrine IFN‐β signaling increases cell‐surface HLA‐Ia expression, strengthens inhibitory KIR signaling in natural killer cells, and thereby enables the affected cell to evade NK cell‐mediated cytotoxicity.
Guihui Qin, Cheung Kwan Yeung, Ye Yi, Dejin Zheng, Miaoman Ye, Chi‐Chong Chio, Jinjie Wu, Siyi Fu, Chu‐Xia Deng, Ren‐He Xu   +9 more
wiley   +1 more source

Medroxyprogesterone abrogates the inhibitory effects of estradiol on vascular smooth muscle cells by preventing estradiol metabolism [PDF]

, 2008
Sequential conversion of estradiol (E) to 2/4-hydroxyestradiols and 2-/4-methoxyestradiols (MEs) by CYP450s and catechol-O-methyltransferase, respectively, contributes to the inhibitory effects of E on smooth muscle cells (SMCs) via estrogen receptor ...
Dubey, Raghvendra K, Imthurn, B., Jackson, E K, Zacharia, Lefteris C, Zacharia, L.C., Wunder, D, Rosselli, Marinella, Delbert G. Gillespie, Gillespie, Delbert G, Jackson, Edwin K, Marinella Rosselli, Rosselli, M, Bruno Imthurn, Gillespie, D.G., Wunder, D., Dubey, R K, Wunder, Dorothea, Jackson, E.K., Zacharia, L C, Raghvendra K. Dubey, Edwin K. Jackson, Imthurn, B, Dubey, R.K., Dorothea Wunder, Gillespie, D G, Lefteris C. Zacharia, Imthurn, Bruno, Rosselli, M.   +27 more
core   +1 more source

SAV1 in Cooperation With FKBP52 Participates in Implantation

Advanced Science, EarlyView.
The MST‐SAV1 complex modulates FKBP52 phosphorylation to fine‐tune PR activity, ensuring timely uterine transition to receptivity under estrogen signaling for implantation. Stromal SAV1 scaffolds MST1/2‐mediated FKBP52 phosphorylation via noncanonical Hippo to promote PR activity.
Yuhan Shao, Yafang Lu, Zhaoyu Jia, Junxiang Ren, Ziyi Ge, Xinyu Liu, Hui Zhao, Zi‐Jiang Chen, Junhao Yan, Wei Wang, Jia Yuan   +10 more
wiley   +1 more source

Insights from the Structure of Estrogen Receptor into the Evolution of Estrogens: Implications for Endocrine Disruption [PDF]

, 2011
In the last decade, there has been important progress in understanding the origins and evolution of receptors for adrenal steroids (aldosterone, cortisol) and sex steroids (estradiol, progesterone, testosterone) due to the sequencing of genomes from ...
Michael E. Baker
core   +1 more source

Flexible IGZO Field‐Effect Transistor Biosensor Platform for Mechanically Stable and Cortisol Detection

Advanced Electronic Materials, EarlyView.
A flexible indium–gallium–zinc oxide field‐effect transistor platform on polyimide is developed for electrostatic cortisol detection. Wafer‐scale fabricated devices exhibit uniform electrical characteristics and maintain stable operation under mechanical bending.
Ngoc Thanh Ho, Sina Jamali, Tuan‐Khoa Nguyen, Nam‐Trung Nguyen   +3 more
wiley   +1 more source

Growth Hormone Potentiates 17β-Estradiol- Dependent Breast Cancer Cell Proliferation Independently of IGF-I Receptor Signaling [PDF]

, 2013
Estrogen action in mammary gland development and breast cancer progression is tightly linked to the GH/IGF-I axis. Although many of the effects of GH on mammary gland growth and development require IGF-I, the extent to which GH action in breast cancer ...
Jonna Frasor (841097), Dana L. Felice (7945196), Shuangping Zhao (138768), Terry G. Unterman (7945160), Daniel L. Lantvit (7945199), Qi Shen (166827), Steven M. Swanson (1324665), Lamiaa El-Shennawy (7353647)   +7 more
core   +4 more sources

Tumor and peritumoral tissue hormonal background features in patients with rare types of endometrial cancer

Исследования и практика в медицине
Serous endometrial intraepithelial carcinoma (SEIC) and clear cell carcinoma of the endometrium (CCEC) belong to pathogenetic type II without evidence of hyperestrogenism, are often detected late in the course of the disease, and are characterized by an ...
E. M. Frantsiyants, V. A. Bandovkina, A. P. Menshenina, T. I. Moiseenko, M. A. Rogozin, Yu. A. Pogorelova, I. V. Kaplieva, E. I. Surikova, I. V. Neskubina, N. D. Cheryarina, E. V. Verenikina   +10 more
doaj   +1 more source

Korelasi Kadar Estradiol dan Kadar Leptin dengan Profil Lipid pada Wanita Obesitas, Overweight dan Berat Badan Normal di Kota Banda Aceh

, 2015
Background: The prevalence of obesity at woman was higher than man. Obesity related to leptin resistance that causes hipertrigliseridemia that known as an overview of lipid metabolism disorders.
Fitri, Yulia
core  

Synthesis of a β-Estradiol-Biotin Chimera that Potently Heterodimerizes Estrogen Receptor and Streptavidin Proteins in a Yeast Three-Hybrid System

, 2016
Small molecules that dimerize proteins in living cells provide powerful probes of biological processes and have potential as tools for the identification of protein targets of natural products.
Smita S. Muddana (2705911), Stephen L. Hussey (2987397), Blake R. Peterson (120721)   +2 more
core   +1 more source