Results 91 to 100 of about 305,342 (299)
Development of Protacs to Target Cancer-promoting Proteins for Ubiquitination and Degradation [PDF]
, 2003 The proteome contains hundreds of proteins that in theory could be excellent therapeutic targets for the treatment of human diseases. However, many of these proteins are from functional classes that have never been validated as viable candidates for the ...
Crews, Craig M. +6 more
core +1 more source
Arthritis &Rheumatology, EarlyView.Objective Osteoarthritis, the leading cause of disability worldwide, disproportionately affects women, yet sex remains an overlooked determinant. This disparity stems from sex‐specific differences in injury susceptibility—a major risk factor for disease.
Hope D. Welhaven +6 more
wiley +1 more source
Tamoxifen: an FDA approved drug with neuroprotective effects for spinal cord injury recovery
Neural Regeneration Research, 2016 Spinal cord injury (SCI) is a condition without a cure, affecting sensory and/or motor functions. The physical trauma to the spinal cord initiates a cascade of molecular and cellular events that generates a non-permissive environment for cell survival ...
Jennifer M Colón, Jorge D Miranda
doaj +1 more source
Removal of endocrine disrupting chemicals using low pressure reverse osmosis membrane [PDF]
, 2009 Endocrine disrupting chemicals (EDCs) are one of the major focuses of contaminants in current environmental issues, as they can cause adverse health effects on animals and human, particularly to endocrine function.
Abd. Razak, Azri Rasyidi
core
Issues arising when interpreting results from an in vitro assay for estrogenic activity [PDF]
, 2000 Concern about possible adverse effects caused by the inadvertent exposure of humans and wildlife to endocrine-active chemicals, has led some countries to develop an in vivo–in vitro screening program for endocrine effects.
Beresford, NA +3 more
core +1 more source
Pharmacogenetic CYP2B6 variants affect steroid hormone metabolism in human breast cancer cells
British Journal of Clinical Pharmacology, EarlyView.Common genetic CYP2B6 variants correlate with adverse breast cancer outcome. The oestrogen metabolites estriol and 16‐epiestriol, which are formed downstream of CYP2B6‐catalysed 16α/β‐hydroxytestosterone, may be linked to elevated breast cancer risk and might increase due to the demonstrated CYP2B6 variants‐related metabolic shifts.
Marco Hoffmann +5 more
wiley +1 more source
β-arrestin regulates estradiol membrane-initiated signaling in hypothalamic neurons. [PDF]
, 2015 Estradiol (E2) action in the nervous system is the result of both direct nuclear and membrane-initiated signaling (EMS). E2 regulates membrane estrogen receptor-α (ERα) levels through opposing mechanisms of EMS-mediated trafficking and internalization ...
Abrams, Matthew C +2 more
core +3 more sources
British Journal of Clinical Pharmacology, EarlyView.Aims While pregnancy‐related changes in phase I enzyme activity are well‐documented, less is known about the impact on phase II enzymes. This study aimed to test the hypothesis that changes in the pharmacokinetics (PK) of uridine 5′‐diphosphoglucuronosyltransferase (UGT) substrates during pregnancy result from altered enzyme expression or activity ...
William Saffaf +6 more
wiley +1 more source
Estrogen, angiogenesis, immunity and cell metabolism: Solving the puzzle [PDF]
, 2018 Estrogen plays an important role in the regulation of cardiovascular physiology and the immune system by inducing direct effects on multiple cell types including immune and vascular cells. Sex steroid hormones are implicated in cardiovascular protection,
Bolego, Chiara +5 more
core +2 more sources
BMEMat, EarlyView.This review provides an overview of the properties, composites and application of two‐dimensional (2D) nanomaterials for wearable electrochemical biosensors. Also, the challenges and future prospects of utilizing 2D nanomaterials in wearable electrochemical biosensor applications are discussed.
Kou Zhang +8 more
wiley +1 more source