Results 61 to 70 of about 305,342 (299)

A non-synonymous coding change in the CYP19A1 gene Arg264Cys (rs700519) does not affect circulating estradiol, bone structure or fracture [PDF]

, 2011
Background The biosynthesis of estrogens from androgens is catalyzed by aromatase P450 enzyme, coded by the CYP19A1 gene on chromosome 15q21.2. Genetic variation within the CYP19A1 gene sequence has been shown to alter the function of the enzyme.
Wang, J.Z., Deogan, M.S., Lewis, J.R., Chew, S., Mullin, B.H., McNab, T.J., Wilson, S.G., Ingley, E., Prince, R.L.   +8 more
core   +3 more sources

Fosl2 Regulates FSH‐Dependent Follicle Maturation Through Feedback Amplification of FSH/FSHR Signaling

Advanced Science, EarlyView.
This study identifies a FOSL2‐driven positive feedback loop that amplifies FSH/FSHR signaling. During FSH‐dependent follicle maturation, FSH induces Fosl2 expression via the cAMP‐PKA‐CREB cascade. FOSL2 in turn binds the promoters of Fshr and estrogen‐biosynthesis genes to enhance their transcription, thereby increasing Fshr mRNA level and amplifying ...
Hongru Shi, Chaoli Chen, Zaohong Ran, Jianning Liao, Zian Wu, Xiaodong Wang, Yongheng Zhao, Wenkai Ke, Bowen Tan, Yun Liu, Youqiang Su, Wei Ren, Xiang Li, Changjiu He   +13 more
wiley   +1 more source

Acute progesterone feedback on gonadotropin secretion is not demonstrably altered in estradiol‐pretreated women with polycystic ovary syndrome

Physiological Reports, 2022
Women with polycystic ovary syndrome (PCOS) demonstrate gonadotropin‐releasing hormone (GnRH) pulse generator resistance to suppression with 7 days of progesterone and estradiol administration.
Su Hee Kim, Jessica A. Lundgren, James T. Patrie, Christine M. Burt Solorzano, Christopher R. McCartney   +4 more
doaj   +1 more source

Targeting metabolic pathways: a novel therapeutic direction for type 2 diabetes

Frontiers in Cellular and Infection Microbiology, 2023
BackgroundType 2 diabetes mellitus (T2DM) is a prevalent metabolic disease that causes multi-organ complications, seriously affecting patients’ quality of life and survival.
Zhihui Song, Zhihui Song, An Yan, Zehui Guo, Zehui Guo, Yuhang Zhang, Yuhang Zhang, Tao Wen, Tao Wen, Zhenzhen Li, Zhenzhen Li, Zhihua Yang, Zhihua Yang, Rui Chen, Yi Wang, Yi Wang   +15 more
doaj   +1 more source

Effect of spironolactone and potassium canrenoate on cytosolic and nuclear androgen and estrogen receptors of rat liver [PDF]

, 1987
Spironolactone and potassium canrenoate are diuretics that are used widely for management of cirrhotic ascites. The administration of spironolactone frequently leads to feminization, which has been noted less frequently with the use of potassium ...
Alfredo Di Leo, Antonio Francavilla, Armanini, Aten, Bannister, Bellati, Boisselle, Bradford, Burton, Chopra, Clark, Duffy, Dupont, Eagon, Eagon, Eagon, Eagon, Farrell, Francavilla, Francavilla, Francavilla, Francesco Guglielmi, Fromatin, Giuseppe Fanizza, Greenblatt, Gustafsson, Gustafsson, Huffman, Kneifel, Lorenzo Polimeno, Loriaux, Marco, Menard, Michele Barone, Niewoehner, Norstedt, Patricia K. Eagon, Porter, Porter, Powell-Jones, Rifka, Rogerson, Scatchard, Serafini, Thomas E. Starzl, Turocy, Van Thiel   +46 more
core   +1 more source

NET‐DNA Activates the ANXA2/TMEM215/BiP Axis to Promote Mitophagy‐Mediated Anoikis Resistance in Endometriosis

Advanced Science, EarlyView.
NET‐DNA is enriched during early endometriotic lesion establishment and drives anoikis resistance by promoting an ANXA2–TMEM215–BiP axis. This pathway strengthens ER–mitochondria contacts, enhances PINK1/Parkin‐associated mitophagy, preserves mitochondrial homeostasis, and supports ectopic stromal cell survival, thereby facilitating lesion persistence ...
Honglin Wang, Yanling Gou, Huiyan Zhang, Hongli Wang, Beidi Wang, Jinming Liu, Yingying Cao, Ruru Bai, Yuxin Zhao, Xu Han, Chao Feng, Xin Huang, Zongfeng Zhang   +12 more
wiley   +1 more source

Association between polyunsaturated fatty acid intake and estradiol levels among U.S. women

Frontiers in Nutrition
BackgroundPolyunsaturated fatty acids (PUFAs) play a crucial role in maintaining homeostasis in the body. However, research on the relationship between PUFA intake and estradiol levels is limited.
Lange Guo, Yukui Nan, Kangni Liang, Lizhong Yao, Jiuzhi Li   +4 more
doaj   +1 more source

Serum estradiol to testosterone ratio as a novel predictor of severe preeclampsia in the first trimester

The Journal of Clinical Hypertension, 2023
Preeclampsia (PE) is the most common medical complication during pregnancy and the second leading cause of maternal death worldwide. However, a better predictive model of PE remains to be explored.
Yongmei Shen, Jiasong Cao, Liying Yao, Shanshan Li, Xiaomin Zhao, Wen Li, Zhuo Wei, Lei Zhang, Jianxi Wang, Ying Chang   +9 more
doaj   +1 more source

The pituitary TGFb1 system as a novel target for the treatment of resistant prolactinomas [PDF]

, 2016
Prolactinomas are the most frequently observed pituitary adenomas and most of themrespond well to conventional treatment with dopamine agonists (DAs).
Camilletti, María Andrea, Diaz, Graciela Susana, Recouvreux, Maria Victoria, Rifkin, Daniel B.   +3 more
core   +2 more sources

Atroposelective Construction of Axially Chiral Tetraarylethenes Via NHC‐Catalyzed Desymmetrization

Advanced Science, EarlyView.
We report the first NHC‐catalyzed atroposelective synthesis of axially chiral TAEs via oxidative desymmetrization of prochiral TAE dialdehydes. This catalytic strategy operates under mild conditions and accommodates a broad range of phenolic and nitrogen nucleophiles, delivering diverse axially chiral TAEs in good yields and up to 99% ee.
Yang‐Ze Zheng, Ting‐Rui Luan, Ming‐Hao Song, Zhaofeng Sun, Chuan‐Jun Lu, Long‐Long Xi, Ren‐Rong Liu   +6 more
wiley   +1 more source