Results 51 to 60 of about 213,022 (296)

Estrone and estradiol concentrations in human ovaries, testes, and adrenals during the first two years of life [PDF]

, 1987
To determine the origin of estrogens in infant blood, we measured estrone (E1) and estradiol (E2) in the gonads of 50 girls and 64 boys who died suddenly between birth and 2 yr of age as well as in the adrenals of 18 of these infant girls and 16 of the ...
Eisenmenger, Wolfgang, Bidlingmaier, F., Dorr, H. G., Strom, T. M., Knorr, D.   +4 more
core   +1 more source

3D model of amphioxus steroid receptor complexed with estradiol [PDF]

, 2009
The origins of signaling by vertebrate steroids are not fully understood. An important advance was the report that an estrogen-binding steroid receptor [SR] is present in amphioxus, a basal chordate with a similar body plan as vertebrates.
Michael E. Baker, David J. Chang
core  

Dual Role of Tamoxifen in Enhancing STING and CEACAM1 Expression to Prime a Favorable Tumor Microenvironment for Anti‐TIM3 Immunotherapy

Advanced Science, EarlyView.
Anti‐PD‐1/PD‐L1 blockade has revolutionized cancer immunotherapy, but is ineffective against endocrine‐treated (i.e., Tamoxifen), relapsed ER+ breast cancer (BC) patients. This study provides insight into the sub‐optimal response of ER+BCs to anti‐PD‐1/PD‐L1 blockade – highlighting the induction of STING and the CEACAM1/TIM3 axis after chronic ...
Marvin Angelo E Aberin, Saurabh Singh, Soumya Chatterjee, Guang‐Zhi Sui, Yi‐Fu Wang, Ya‐Ting Lu, Yu‐Ling Lee, Kun‐Yuan Lin, Joy Khag, Ta‐Yu Liu, Shao‐Han Chang, Wai‐Mui Cheung, Hsiao‐Chin Hong, Ren‐Jun Hsu, Chen‐Yang Shen, Chia‐Wei Li, Weng‐Lang Yang, Yao‐Ming Chang, Shih‐Yu Chen, Chandan Guha, Shu‐Ping Wang   +20 more
wiley   +1 more source

Acute progesterone feedback on gonadotropin secretion is not demonstrably altered in estradiol‐pretreated women with polycystic ovary syndrome

Physiological Reports, 2022
Women with polycystic ovary syndrome (PCOS) demonstrate gonadotropin‐releasing hormone (GnRH) pulse generator resistance to suppression with 7 days of progesterone and estradiol administration.
Su Hee Kim, Jessica A. Lundgren, James T. Patrie, Christine M. Burt Solorzano, Christopher R. McCartney   +4 more
doaj   +1 more source

Targeting metabolic pathways: a novel therapeutic direction for type 2 diabetes

Frontiers in Cellular and Infection Microbiology, 2023
BackgroundType 2 diabetes mellitus (T2DM) is a prevalent metabolic disease that causes multi-organ complications, seriously affecting patients’ quality of life and survival.
Zhihui Song, Zhihui Song, An Yan, Zehui Guo, Zehui Guo, Yuhang Zhang, Yuhang Zhang, Tao Wen, Tao Wen, Zhenzhen Li, Zhenzhen Li, Zhihua Yang, Zhihua Yang, Rui Chen, Yi Wang, Yi Wang   +15 more
doaj   +1 more source

The Mind From Within: Visceral Roots of Human Cognition

Advanced Science, EarlyView.
The physiological activity of visceral organs, such as the heart, the lungs, and the gut, is surprisingly linked to many sophisticated mental operations, such as remembering the past, being aware of ourselves, making choices, and forging social bonds.
Alessandro Monti, Salvatore Maria Aglioti   +1 more
wiley   +1 more source

Association between polyunsaturated fatty acid intake and estradiol levels among U.S. women

Frontiers in Nutrition
BackgroundPolyunsaturated fatty acids (PUFAs) play a crucial role in maintaining homeostasis in the body. However, research on the relationship between PUFA intake and estradiol levels is limited.
Lange Guo, Yukui Nan, Kangni Liang, Lizhong Yao, Jiuzhi Li   +4 more
doaj   +1 more source

Serum estradiol to testosterone ratio as a novel predictor of severe preeclampsia in the first trimester

The Journal of Clinical Hypertension, 2023
Preeclampsia (PE) is the most common medical complication during pregnancy and the second leading cause of maternal death worldwide. However, a better predictive model of PE remains to be explored.
Yongmei Shen, Jiasong Cao, Liying Yao, Shanshan Li, Xiaomin Zhao, Wen Li, Zhuo Wei, Lei Zhang, Jianxi Wang, Ying Chang   +9 more
doaj   +1 more source

Estradiol inhibits phosphorylation of JAK/STAT, PI3K/AKT and expression of IL-17A in mouse mononuclear cells treated with IL-36β

Pifu-xingbing zhenliaoxue zazhi, 2023
Objective To investigate the effects of β-estradiol (E2) on the phosphorylation of JAK/STAT, PI3K/AKT signaling pathways and the expression of IL-17A in mouse spleen mononuclear cells treated with IL-36β. Methods The spleens were isolated from female SPF
Shuang LIU, Shanshan YANG, Chunchan ZHENG, Sujun LUO, Na WEI, Sirui LI, Jianqiang SHI, Rongyi CHEN   +7 more
doaj   +1 more source

Real‐Time in Vivo Monitoring of Circulating Endometrial Cells: Uncovering Systemic Dissemination and Temporal Fluctuations in Endometriosis

Advanced Science, EarlyView.
A dual‐color pseudo‐menstrual mouse model enables real‐time tracing of circulating endometrial cells (CECs) from uterine and ectopic sources. The study reveals menstrual‐phase‐dependent, burst‐like CEC release, distinct postoperative behaviors of different CEC origins, and a potential association with prolactin fluctuations, providing an in vivo ...
Shang Wang, Chenyu Hou, Buyun Li, Hongyan Cheng, Xue Ye, Honglan Zhu, Yanmin Li, Rui Chen, Sihan Dong, Yi Li, Huiping Liu, Chen Zhang, Rui Zhang, Hongyi Hou, Xunbin Wei, Xiaohong Chang   +15 more
wiley   +1 more source