Results 51 to 60 of about 220,059 (299)

Beta1 subunits enable fentanyl‐induced BK channel activation and opioid regulation of cerebral artery diameter

FEBS Open Bio, EarlyView.
During the current opioid crisis, the majority of overdose deaths are attributed to ultra‐potent synthetic opioids, such as fentanyl. While fentanyl exerts its action via opioid receptors, we propose that potassium channels in the brain blood vessels may also sense fentanyl.
Shiwani Thapa, Mohammed Nooh, Akhil Geddati, Alex Dopico, Anna N. Bukiya   +4 more
wiley   +1 more source

Acute progesterone feedback on gonadotropin secretion is not demonstrably altered in estradiol‐pretreated women with polycystic ovary syndrome

Physiological Reports, 2022
Women with polycystic ovary syndrome (PCOS) demonstrate gonadotropin‐releasing hormone (GnRH) pulse generator resistance to suppression with 7 days of progesterone and estradiol administration.
Su Hee Kim, Jessica A. Lundgren, James T. Patrie, Christine M. Burt Solorzano, Christopher R. McCartney   +4 more
doaj   +1 more source

Targeting metabolic pathways: a novel therapeutic direction for type 2 diabetes

Frontiers in Cellular and Infection Microbiology, 2023
BackgroundType 2 diabetes mellitus (T2DM) is a prevalent metabolic disease that causes multi-organ complications, seriously affecting patients’ quality of life and survival.
Zhihui Song, Zhihui Song, An Yan, Zehui Guo, Zehui Guo, Yuhang Zhang, Yuhang Zhang, Tao Wen, Tao Wen, Zhenzhen Li, Zhenzhen Li, Zhihua Yang, Zhihua Yang, Rui Chen, Yi Wang, Yi Wang   +15 more
doaj   +1 more source

Sex and regional differences in estradiol content in the prefrontal cortex, amygdala and hippocampus of adult male and female rats.

, 2009
In general, the behavioral and neural effects of estradiol administration to males and females differ. While much attention has been paid to the potential structural, cellular and sub-cellular mechanisms that may underlie such differences, as of yet ...
Barker, Jennifer Marie, Galea, Liisa A. M., Liisa A.M. Galea, Jennifer M. Barker   +3 more
core   +1 more source

Peripheral Neutrophil Activation and Extracellular Trap Formation in Amyotrophic Lateral Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
Markers of neutrophil activation are increased in plasma during ALS, and markers of NET formation associate with ALS survival. ABSTRACT Objectives Peripheral neutrophil levels in amyotrophic lateral sclerosis (ALS) inversely correlate with survival, suggesting a role for neutrophils in disease progression.
Lillia A. Baird, Haley McQuown, Jihyun Park, Samuel J. Teener, Ian F. Webber‐Davis, Andrew D. Carter, Dae‐Gyu Jang, Eva L. Feldman, Stephen A. Goutman, Benjamin J. Murdock   +9 more
wiley   +1 more source

Association between polyunsaturated fatty acid intake and estradiol levels among U.S. women

Frontiers in Nutrition
BackgroundPolyunsaturated fatty acids (PUFAs) play a crucial role in maintaining homeostasis in the body. However, research on the relationship between PUFA intake and estradiol levels is limited.
Lange Guo, Yukui Nan, Kangni Liang, Lizhong Yao, Jiuzhi Li   +4 more
doaj   +1 more source

Serum estradiol to testosterone ratio as a novel predictor of severe preeclampsia in the first trimester

The Journal of Clinical Hypertension, 2023
Preeclampsia (PE) is the most common medical complication during pregnancy and the second leading cause of maternal death worldwide. However, a better predictive model of PE remains to be explored.
Yongmei Shen, Jiasong Cao, Liying Yao, Shanshan Li, Xiaomin Zhao, Wen Li, Zhuo Wei, Lei Zhang, Jianxi Wang, Ying Chang   +9 more
doaj   +1 more source

Estradiol inhibits phosphorylation of JAK/STAT, PI3K/AKT and expression of IL-17A in mouse mononuclear cells treated with IL-36β

Pifu-xingbing zhenliaoxue zazhi, 2023
Objective To investigate the effects of β-estradiol (E2) on the phosphorylation of JAK/STAT, PI3K/AKT signaling pathways and the expression of IL-17A in mouse spleen mononuclear cells treated with IL-36β. Methods The spleens were isolated from female SPF
Shuang LIU, Shanshan YANG, Chunchan ZHENG, Sujun LUO, Na WEI, Sirui LI, Jianqiang SHI, Rongyi CHEN   +7 more
doaj   +1 more source

ESTRADIOL data

, 2015
Cumulative, log transformed data on estradiol.
Andrzej Galbarczyk (845433), Thune, Inger, Kapiszewska, Maria, Ziomkiewicz, Anna, Ellison, Peter T., Malgorzata Kalemba-Drozdz (3240978), Anna Ziomkiewicz (845431), Jasienska, Grazyna, Grazyna Jasienska (845435), Kalemba-Drozdz, Malgorzata, Ilona Nenko (3240990), Michal Jasienski (3240981), Nenko, Ilona, Maria Kapiszewska (3240984), Galbarczyk, Andrzej, Peter T. Ellison (3240987), Inger Thune (315574), Jasienski, Michal   +17 more
core   +1 more source

Dual Role of Tamoxifen in Enhancing STING and CEACAM1 Expression to Prime a Favorable Tumor Microenvironment for Anti‐TIM3 Immunotherapy

Advanced Science, EarlyView.
Anti‐PD‐1/PD‐L1 blockade has revolutionized cancer immunotherapy, but is ineffective against endocrine‐treated (i.e., Tamoxifen), relapsed ER+ breast cancer (BC) patients. This study provides insight into the sub‐optimal response of ER+BCs to anti‐PD‐1/PD‐L1 blockade – highlighting the induction of STING and the CEACAM1/TIM3 axis after chronic ...
Marvin Angelo E Aberin, Saurabh Singh, Soumya Chatterjee, Guang‐Zhi Sui, Yi‐Fu Wang, Ya‐Ting Lu, Yu‐Ling Lee, Kun‐Yuan Lin, Joy Khag, Ta‐Yu Liu, Shao‐Han Chang, Wai‐Mui Cheung, Hsiao‐Chin Hong, Ren‐Jun Hsu, Chen‐Yang Shen, Chia‐Wei Li, Weng‐Lang Yang, Yao‐Ming Chang, Shih‐Yu Chen, Chandan Guha, Shu‐Ping Wang   +20 more
wiley   +1 more source