Results 51 to 60 of about 158,816 (117)

The Relationship between Time, Race, and Estrogen Receptor Alpha in Estradiol-Induced Dermal Fibrosis

Biomedicines
In the skin, estradiol (E2) promotes profibrotic and proinflammatory cytokines, contributing to extracellular matrix (ECM) deposition. However, the magnitude of the response differs.
DeAnna Baker Frost, Alisa Savchenko, Carol Feghali-Bostwick, Bethany Wolf   +3 more
doaj   +1 more source

Urinary Glyphosate Concentrations and Serum Sex Hormones in a Nationally Representative U.S. Sample: NHANES 2017–2018

Life
Glyphosate and glyphosate-based herbicides (GBHS) are the most widely used herbicides worldwide, yet their potential endocrine-disrupting effects in humans remain inadequately studied.
Wen-Yang Wu, Du-Sheng Wang, Hsuan-Cheng Lin, Chikang Wang, Chien-Yu Lin   +4 more
doaj   +1 more source

Estradiol mediates dendritic spine plasticity in the nucleus accumbens core through activation of mGluR5

Brain Structure and Function, 2014
Accumulating evidence from human and rodent studies suggests that females are more sensitive to the motivating and rewarding properties of drugs of abuse.
B. Peterson, P. Mermelstein, R. Meisel
semanticscholar   +1 more source

Effects of Testosterone and Its Major Metabolites upon Different Stages of Neuron Survival in the Dentate Gyrus of Male Rats

Biomolecules
Testosterone has been shown to enhance hippocampal neurogenesis through increased cell survival, but which stages of new neuron development are influenced by testosterone remains unclear.
Mark D. Spritzer, Ethan A. Roy, Kelsey M. K. Calhoun, Zachary E. Schneider-Lynch, Leslie Panella, Charlotte Michaelcheck, April Qian, Evan D. Kelly, Hadley Barr, Emma Hall, Blaine Cunningham, Hieu H. M. Nguyen, Dani Xu, Jennifer M. Barker, Liisa A. M. Galea   +14 more
doaj   +1 more source

Decreased nitric oxide levels in the hippocampus may play a role in learning and memory deficits in ovariectomized rats treated by a high dose of estradiol

Arquivos de Neuro-Psiquiatria, 2012
The effects of a high estradiol dose on memory and on nitric oxide metabolites in hippocampal tissues were investigated. Sham-Est and OVX-Est Groups were treated with 4 mg/kg of estradiol valerate for 12 weeks.
Reihaneh Sadeghian, Masoud Fereidoni, Mohammad Soukhtanloo, Hamid Azizi-Malekabadi, Mahmoud Hosseini   +4 more
doaj   +1 more source

Serum interleukin-17 expression in postmenopausal women and its relation to osteoporosis and risk of fractures

Journal of the Arab Society for Medical Research
Background/Aim Osteoporosis is a musculoskeletal disorder that is characterized by low bone mineral density (BMD) as well as an elevated risk of fractures.
Samar G. Soliman, Samah S. Youssef, Amira K. Mohammed, Dalia S. Saif   +3 more
doaj   +1 more source

Tamoxifen: an FDA approved drug with neuroprotective effects for spinal cord injury recovery

Neural Regeneration Research, 2016
Spinal cord injury (SCI) is a condition without a cure, affecting sensory and/or motor functions. The physical trauma to the spinal cord initiates a cascade of molecular and cellular events that generates a non-permissive environment for cell survival ...
Jennifer M Colón, Jorge D Miranda
doaj   +1 more source

Estradiol modulates medial prefrontal cortex and amygdala activity during fear extinction in women and female rats

Biological Psychiatry, 2011
Background Men and women differ in their ability to extinguish fear. Fear extinction requires the activation of brain regions including the ventromedial prefrontal cortex (vmPFC) and amygdala.
Mohamed A Zeidan, Sarah A. Igoe, C. Linnman, Antonia G. Vitalo, John B. Levine, A. Klibanski, J. Goldstein, M. Milad   +7 more
semanticscholar   +1 more source

Tumor and peritumoral tissue hormonal background features in patients with rare types of endometrial cancer

Исследования и практика в медицине
Serous endometrial intraepithelial carcinoma (SEIC) and clear cell carcinoma of the endometrium (CCEC) belong to pathogenetic type II without evidence of hyperestrogenism, are often detected late in the course of the disease, and are characterized by an ...
E. M. Frantsiyants, V. A. Bandovkina, A. P. Menshenina, T. I. Moiseenko, M. A. Rogozin, Yu. A. Pogorelova, I. V. Kaplieva, E. I. Surikova, I. V. Neskubina, N. D. Cheryarina, E. V. Verenikina   +10 more
doaj   +1 more source

Estradiol Increases the Sensitivity of Hippocampal CA1 Pyramidal Cells to NMDA Receptor-Mediated Synaptic Input: Correlation with Dendritic Spine Density

Journal of Neuroscience, 1997
Previous studies have shown that estradiol induces new dendritic spines and synapses on hippocampal CA1 pyramidal cells. We have assessed the consequences of estradiol-induced dendritic spines on CA1 pyramidal cell intrinsic and synaptic ...
C. Woolley, N. Weiland, B. McEwen, P. Schwartzkroin   +3 more
semanticscholar   +1 more source