Identification of Estradiol Benzoate as an Inhibitor of HBx Using Inducible Stably Transfected HepG2 Cells Expressing HiBiT Tagged HBx [PDF]
Molecules, 2022 HBx plays a significant role in the cccDNA epigenetic modification regulating the hepatitis B virus (HBV) life cycle and in hepatocyte proliferation and carcinogenesis. By using the sleeping-beauty transposon system, we constructed a tetracycline-induced
Jingjing He +14 more
doaj +4 more sources
Vitamin B12 and estradiol benzoate improve memory retrieval through activation of the hippocampal AKT, BDNF, and CREB proteins in a rat model of multiple sclerosis [PDF]
Iranian Journal of Basic Medical Sciences, 2021 Objective(s): Multiple sclerosis (MS) causes extensive damage in the hippocampus. Vitamin B12 (vit B12) and estradiol benzoate (EB) have anti-inflammatory and re-myelination properties that make them proper in improvement of cognitive impairment.
Narjes Taherian +5 more
doaj +3 more sources
Intravaginal administration of estradiol benzoate capsule for estrus synchronization in goats [PDF]
The Journal of Reproduction and Development, 2021 Estrus synchronization requires multiple treatments of hormonal drugs, requiring considerable time and cost. The aim of the present study was to develop an estrus synchronization protocol using intravaginal administration of estradiol benzoate (EB ...
Sayaka MATSUMOTO +2 more
doaj +3 more sources
Plasma Estradiol and Endometrial Edema Profile in Acyclic Mares After Single Administration of 17-β Estradiol, Estradiol Benzoate and Estradiol Cypionate. [PDF]
Reprod Domest AnimABSTRACTA longer endometrial exposure to estradiol before progesterone has been shown to be beneficial in cyclic and acyclic recipient mares. Therefore, the selection of an estradiol ester that promotes longer endometrial exposure to estradiol using a single administration would be advantageous when preparing acyclic mares as embryo recipients.
Barbosa LA +7 more
europepmc +3 more sources
Investigation of Antiparasitic Activity of Two Marine Natural Products, Estradiol Benzoate, and Octyl Gallate, on Toxoplasma gondii In Vitro [PDF]
Frontiers in Pharmacology, 2022 Toxoplasmosis, caused by Toxoplasma gondii, is a common disease worldwide and could be severe and even fatal in immunocompromised individuals and fetuses.
Daiqiang Lu +7 more
doaj +2 more sources
Protective Effects of Irbesartan, an Angiotensin Receptor Blocker with PPARγ Agonistic Activity, against Estradiol Benzoate-Induced Endometrial Hyperplasia and Atypia in Female Rats via Modulation of TNFα/Survivin Pathway [PDF]
Pharmaceuticals, 2021 Endometrial hyperplasia (EH) is a common gynecological problem and may progress to carcinoma. Early detection and management of EH are mandatory for the prevention of endometrial cancer.
Mohamed A. Morsy +3 more
doaj +2 more sources
Impact of Equine Chorionic Gonadotropin Associated with Temporary Weaning, Estradiol Benzoate, or Estradiol Cypionate on Timed Artificial Insemination in Primiparous Bos Indicus Cows [PDF]
Brazilian Archives of Biology and Technology, 2016 The study aimed to determine the impact of equine chorionic gonadotropin (eCG) associated with different timed artificial insemination (TAI) protocols on the pregnancy rate (PR) in Bos indicus cows previously treated with progesterone.
Andre Luis Bastos Souza +6 more
doaj +2 more sources
Identification of potential VP40 inhibitor of Marburg virus through molecular docking, pharmacokinetic analysis and molecular dynamics simulation [PDF]
Scientific ReportsWest Africa has been experiencing a resurgence of Marburg virus disease (MVD), a zoonotic pathogen that causes severe hemorrhagic fever in both humans and primates. Regretfully, there are not any effective medications on the market right now. The binding
Rohit Das +3 more
doaj +2 more sources
Alterations in liver enzymes and histopathological changes in an animal model of polycystic ovary syndrome [PDF]
Open Veterinary JournalBackground: Polycystic ovary syndrome (PCOS) is a prevalent endocrine disorder that can lead to metabolic and reproductive complications, including liver dysfunction.
Yudit Oktanella +6 more
doaj +2 more sources
Integrative genomic and bioinformatic prioritization of drug repurposing candidates for prostate cancer [PDF]
BMC Pharmacology and ToxicologyObjective Prostate cancer remains a prevalent global health challenge, with limited treatment options for advanced stages. There is a critical need to identify effective therapies through systematic integration of genomic and biological data.
Lalu Muhammad Irham +12 more
doaj +2 more sources