Results 1 to 10 of about 12,662 (138)

Multistep Synthesis and In Vitro Anticancer Evaluation of 2-Pyrazolyl-Estradiol Derivatives, Pyrazolocoumarin-Estradiol Hybrids and Analogous Compounds [PDF]

Molecules, 2020
Although the hormone independent cytotoxic activity of several estradiol derivatives endowed with a simple substituent at C-2 has been reported so far, 2-heterocyclic and 2,3-condensed analogs are less investigated from both synthetic and pharmacological
Barnabás Molnár, Mohana Krishna Gopisetty, Dóra Izabella Adamecz, Mónika Kiricsi, Éva Frank   +4 more
doaj   +6 more sources

Synthesis and Antitumor Evaluation of Novel Hybrids of Phenylsulfonylfuroxan and Estradiol Derivatives [PDF]

ChemistryOpen, 2020
Fifteen novel furoxan‐based nitric oxide (NO) releasing hybrids of estradiol derivatives were synthesized and evaluated in vitro anti‐proliferative activity in MDA‐MB‐231, A2780, Hela and HUVEC cell lines. Most of them displayed potent anti‐proliferative
Qi Wan, Yan Deng, Yaoqing Huang, Zhihui Yu, Chunli Wang, Ke Wang, Assoc. Prof. Jibin Dong, Prof. Ying Chen   +7 more
doaj   +2 more sources

Chemical Synthesis and Biological Evaluation of 3-Substituted Estrone/Estradiol Derivatives as 17β-Hydroxysteroid Dehydrogenase Type 1 Inhibitors Acting via a Reverse Orientation of the Natural Substrate Estrone [PDF]

Molecules, 2023
Estradiol (E2) plays an important role in the progression of diseases such as breast cancer and endometriosis. Inhibition of 17β-hydroxysteroid dehydrogenase type 1 (17β-HSD1), the enzyme that catalyzes the last step in the biosynthesis of the estrogenic
Adrien Djiemeny Ngueta, Jenny Roy, René Maltais, Donald Poirier   +3 more
doaj   +2 more sources

Correction to: Novel sulphamoylated 2-methoxy estradiol derivatives inhibit breast cancer migration by disrupting microtubule turnover and organization [PDF]

Cancer Cell International, 2020
An amendment to this paper has been published and can be accessed via the original article.
Rustelle Janse van Vuuren, Mandie Botes, Tamarin Jurgens, Anna Margaretha Joubert, Iman van den Bout   +4 more
doaj   +2 more sources

Retention behaviour of estradiol derivatives in reversed phase HPLC [PDF]

Acta Periodica Technologica, 2005
Retention behaviour ofestradiol derivatives has been studied by the reversed phase HPLC. LiChrosorb RP-18 column end eluents consisting of methanol respectively aceto-nitrile and water in various proportions, were used.
Ačanski Marijana M., Petrović Slobodan M.   +1 more
doaj   +2 more sources

Novel sulphamoylated 2-methoxy estradiol derivatives inhibit breast cancer migration by disrupting microtubule turnover and organization [PDF]

Cancer Cell International, 2019
Background The estrogen metabolite 2-methoxyestradiol (2ME2) and a number of synthesised derivatives have been shown to bind to microtubules thereby arresting cancer cells in mitosis which leads to apoptosis.
Rustelle Janse van Vuuren, Mandie Botes, Tamarin Jurgens, Anna Margaretha Joubert, Iman van den Bout   +4 more
doaj   +2 more sources

Exploring biomarkers of neurodegenerative risk: associations of oxysterols, sex hormones, and reproductive characteristics in older women [PDF]

Journal of Lipid Research
Women face a higher lifetime risk of developing neurodegenerative diseases such as Alzheimer’s disease and related dementias. The menopausal transition, characterized by a decline in estrogen levels, may affect cholesterol metabolism and ...
Michelle M. Dunk, Ljerka Delac, Stephen R. Rapp, Ira Driscoll, Maria Latorre-Leal, Leslie V. Farland, Bernhard Haring, Holly R. Harris, Su Yon Jung, JoAnn E. Manson, Heather M. Ochs-Balcom, Aladdin H. Shadyab, Julie C. Weitlauf, Hong Xu, Eric Westman, Silvia Maioli   +15 more
doaj   +2 more sources

LncRNA HAND2OT encoding micropeptide regulates the estradiol secretion, proliferation and apoptosis of ovarian follicular theca cells in chickens [PDF]

Poultry Science
Long non-coding RNAs (lncRNAs) are critical regulators of ovarian follicular development. In chicken ovarian follicles, theca cells are primarily responsible for androgen and estradiol biosynthesis and play an important role in chicken follicular ...
Xinmei Shu, Qingqing Wei, Li Kang, Yi Sun, Yunliang Jiang   +4 more
doaj   +2 more sources

Sex Hormones Attenuate Pro‐Inflammatory Gene Expression in Nucleus Pulposus and Annulus Fibrosus Cells in a Cell‐Type Specific Manner [PDF]

JOR Spine
Background Intervertebral disc (IVD) degeneration is a major contributor to back pain and disability. The cause of IVD degeneration is multifactorial, with no disease‐modifying treatments.
Jeffrey L. Hutchinson, Andrew E. Leung, Cheryle A. Séguin   +2 more
doaj   +2 more sources

Normal-phase high performance liquid chromatography of estradiol derivatives on amino- and diol-columns [PDF]

Journal of the Serbian Chemical Society, 2003
The retention behavior of estradiol derivatives was studied by HPLC on chemically bonded polar stationary phases: commercially available amino and diol- columns, as a function of the heptane-propan-1-ol as the mobile phase, when the volume fraction of ...
Ačanski Marijana M.
doaj   +3 more sources