Results 21 to 30 of about 744,343 (249)

Structural characterization of the binding interactions of various endogenous estrogen metabolites with human estrogen receptor α and β subtypes: a molecular modeling study. [PDF]

PLoS ONE, 2013
In the present study, we used the molecular docking approach to study the binding interactions of various derivatives of 17β-estradiol (E2) with human estrogen receptor (ER) α and β. First, we determined the suitability of the molecular docking method to
Pan Wang, Campbell McInnes, Bao Ting Zhu
doaj   +1 more source

In Silico Evaluation of Alpha Mangostin and its Derivatives as a potential Anti-Cancer Agents [PDF]

BIO Web of Conferences
Alpha-Mangostin, a natural xanthone from Garcinia mangostana, and its structurally optimized derivatives were evaluated as anticancer agents targeting estrogen receptor proteins linked to breast cancer: Estrogen Receptor Alpha(3ERT), Estrogen Receptor ...
V Harini Rakshitha, P Maheshwari, P Yamini Devi, Prabhu Puniethaa   +3 more
doaj   +1 more source

Design and Synthesis of Two Bicyclo[3.3.1]nonane-steroid Derivatives

Chemistry Journal of Moldova: General, Industrial and Ecological Chemistry, 2020
This study describes the preparation of two bicyclo[3.3.3]nonane-steroid derivatives from either estradiol or estrone using some reactions such as etherification, addition, nucleophilic substitution and cyclization.
Lauro Figueroa, Alejandra Garcimarero, Rolando Garcia, Francisco Diaz, Marcela Rosas, Virginia Mateu, Maria Lopez, Lenin Hau, Tomas Lopez, Abelardo Camacho, Yaritza Borges   +10 more
doaj   +1 more source

LCAT facilitates transacylation of 17β-estradiol in the presence of HDL3 subfraction

Journal of Lipid Research, 2002
It has been shown that estrogens need to be metabolized to their hydrophobic estrogen ester derivatives to act as antioxidants in lipoproteins. Data suggest that 17β-estradiol (E2) becomes esterified in LCAT-induced reactions and the esters are ...
Anna Höckerstedt, Matti J. Tikkanen, Matti Jauhiainen   +2 more
doaj   +1 more source

Dose-dependent regulation of cell proliferation and collagen degradation by estradiol on ligamentum flavum

, 2017
Background: Estradiol plays an important role in the regulation of collagen metabolism. Deficiency of estradiol has been reported to be associated with the degeneration of many connective tissues.
Chen, Mei-Hsiu;Hu, Chao-Kai;Chen, Pei-Ru;Chen, Yu-Shan;Sun, Jui-Sheng;Chen, Ming-Hong, 孫瑞昇   +1 more
core   +1 more source

GC-MS/MS Determination of Steroid Hormones in Urine Using Solid-Phase Derivatization as an Alternative to Conventional Methods

Molecules, 2022
Solid-phase analytical derivatization (SPAD) is a promising hybrid sample preparation technique combining the clean-up and preconcentration of the sample in a single step. In this work, a novel SPAD method based on the preparation of trimethylsilyl (TMS)
Azamat Temerdashev, Pavel Nesterenko, Ekaterina Dmitrieva, Kseniya Zhurkina, Yu-Qi Feng   +4 more
doaj   +1 more source

Flutamide versus a cyproterone acetate-ethinyl estradiol combination in moderate acne: a pilot randomized clinical trial [PDF]

Background: The use of oral flutamide is rarely investigated in acne therapy. The aim of this study was to compare the efficacy of oral flutamide with that of a cyproterone-estradiol combination in treating acne lesions.
Hassan Adalatkhah, پورفرضی, فرهاد, صادقی, همایون, عدالتخواه, حسن   +3 more
core   +1 more source

Circulating estradiol and its biologically active metabolites in endometriosis and in relation to pain symptoms

Frontiers in Endocrinology, 2023
ObjectivesEndometriosis (EM) is an estrogen-dominant inflammatory disease linked to infertility that affects women of reproductive age. EM lesions respond to hormonal signals that regulate uterine tissue growth and trigger inflammation and pain.
Jean-Philippe Emond, Patrick Caron, Maja Pušić, Véronique Turcotte, David Simonyan, Andrej Vogler, Joško Osredkar, Tea Lanišnik Rižner, Chantal Guillemette, Chantal Guillemette   +9 more
doaj   +1 more source

Detectability of testosterone esters and estradiol benzoate in bovine hair and plasma following pour-on treatment [PDF]

, 2009
The abuse of synthetic esters of natural steroids such as testosterone and estradiol in cattle fattening and sports is hard to detect via routine urine testing. The esters are rapidly hydrolysed in vivo into substances which are also endogenously present
Blokland, M.H., Becker, C., C. Becker, Nielen, M.W.F., Lasaroms, J.J.P., I. Riedmaier, H. H. D. Meyer, Riedmaier, I., A. W. J. M. Nijrolder, Stolker, A.A.M., Meyer, H.H.D., M. J. Groot, J. J. P. Lasaroms, M. H. Blokland, Groot, M.J., Nijrolder, A.W.J.M., M. W. F. Nielen, A. A. M. Stolker   +17 more
core   +1 more source

Novel Locally Active Estrogens Accelerate Cutaneous Wound Healing-Part 2

Scientific Reports, 2017
Estrogen deprivation is associated with delayed healing, while estrogen replacement therapy (ERT) accelerates acute wound healing and protects against development of chronic wounds.
Mario Brufani, Nicoletta Rizzi, Clara Meda, Luigi Filocamo, Francesca Ceccacci, Virginia D’Aiuto, Gabriele Bartoli, Angela La Bella, Luisa M. Migneco, Rinaldo Marini Bettolo, Francesca Leonelli, Paolo Ciana, Adriana Maggi   +12 more
doaj   +1 more source