Results 1 to 10 of about 97,768,097 (202)

Development of an accurate and sensitive assay for 2-methoxyestradiol using derivatization and liquid chromatography-tandem mass spectrometry [PDF]

Practical Laboratory Medicine
2-Methoxyestradiol (2ME) is involved in the pathogenesis of preeclampsia and antitumor activity. In addition to its low concentration in healthy human serum, presence of isomers makes quantification of 2ME for clinical research and laboratory medicine ...
Koji Takahashi, Masaki Takiwaki, Seketsu Fukuzawa, Yoshikuni Kikutani, Kentaro Abe, Tatsuya Higashi, Hironori Kobayashi   +6 more
doaj   +3 more sources

2-Methoxyestradiol Damages DNA in Glioblastoma Cells by Regulating nNOS and Heat Shock Proteins [PDF]

Antioxidants, 2022
Gliomas are the most prevalent primary tumors of the central nervous system (CNS), accounting for over fifty percent of all primary intracranial neoplasms. Glioblastoma (GBM) is the most prevalent form of malignant glioma and is often incurable. The main
Paulina Emilia Bastian, Agnieszka Daca, Agata Płoska, Alicja Kuban-Jankowska, Leszek Kalinowski, Magdalena Gorska-Ponikowska   +5 more
doaj   +2 more sources

Effect of 2‐methoxyestradiol on mammary tumor initiation and progression [PDF]

Cancer Reports
Background The anti‐cancer agent 2‐methoxyestradiol (2‐ME) has been shown to have anti‐proliferative and anti‐angiogenic properties. Previously, the effect of 2‐ME on early‐ and late‐stage breast cancer (BC) was investigated in vivo using a transgenic ...
Kimberly T. Peta, Chrisna Durandt, Marlene B. vanHeerden, Anna M. Joubert, Michael S. Pepper, Melvin A. Ambele   +5 more
doaj   +2 more sources

2‐methoxyestradiol restrains non‐small cell lung cancer tumorigenesis through regulating circ_0010235/miR‐34a‐5p/NFAT5 axis [PDF]

Thoracic Cancer, 2023
Background Non‐small cell lung cancer (NSCLC) is one of the most prevalent and severe malignant tumors in the world and its molecular mechanism is still unclear.
Yong Zhang, Yuanyuan Mi, Chunhui He
doaj   +2 more sources

Ramulus Mori (Sangzhi) Alkaloids Improve Pancreatic β-Cell Function Through Gut Microbial and Intra-Islet 2-Methoxyestradiol Biosynthesis [PDF]

Biomedicines
Background: Ramulus Mori (Sangzhi) Alkaloids (SZ-A) are natural hypoglycemic compounds known to enhance insulin secretion. Given the emerging role of the gut microbiota in regulating β-cell function, in this study, we aimed to investigate whether SZ-A ...
Nan Wu, Lusi Lu, Yiming Liu, Sunyue He, Chunyi Xu, Ying Wu, Yuchen Zhao, Xihua Lin, Wenjing Zhang, Jiaqiang Zhou   +9 more
doaj   +2 more sources

Regulation of Mitochondrial Dynamics in Parkinson’s Disease—Is 2-Methoxyestradiol a Missing Piece? [PDF]

Antioxidants, 2021
Mitochondria, as “power house of the cell”, are crucial players in cell pathophysiology. Beyond adenosine triphosphate (ATP) production, they take part in a generation of reactive oxygen species (ROS), regulation of cell signaling and cell death ...
Paulina Bastian, Jaroslaw Dulski, Anna Roszmann, Dagmara Jacewicz, Alicja Kuban-Jankowska, Jaroslaw Slawek, Michal Wozniak, Magdalena Gorska-Ponikowska   +7 more
doaj   +2 more sources

Self-Nanoemulsifying Drug Delivery System of 2-Methoxyestradiol Exhibits Enhanced Anti-Proliferative and Pro-Apoptotic Activities in MCF-7 Breast Cancer Cells [PDF]

Life, 2022
(1) Background: 2-Methoxyestradiol (2ME) is a metabolite of estrogens and possesses promising anti-proliferative and cytotoxic activities. However, it suffers unfavorable pharmacokinetic characteristics such as absorption after oral administration.
Salwa D. Al-Qahtani, Hawazen H. Bin-Melaih, Eman M. Atiya, Usama A. Fahmy, Lenah S. Binmahfouz, Thikryat Neamatallah, Fahad A. Al-Abbasi, Ashraf B. Abdel-Naim   +7 more
doaj   +2 more sources

2-Methoxyestradiol TPGS Micelles Attenuate Cyclosporine A-Induced Nephrotoxicity in Rats through Inhibition of TGF-β1 and p-ERK1/2 Axis [PDF]

Antioxidants, 2022
The immunosuppressant cyclosporine A (CSA) has been linked to serious renal toxic effects. Although 2-methoxyestradiol (2ME) possesses a wide range of pharmacological abilities, it suffers poor bioavailability after oral administration.
Mohammed W. Al-Rabia, Mohamed A. Alfaleh, Hani Z. Asfour, Waleed S. Alharbi, Mohamed A. El-Moselhy, Nabil A. Alhakamy, Usama A. Fahmy, Osama A. A. Ahmed, Omar Fahmy, Omar M. Rashad, Abdulmohsin J. Alamoudi, Ashraf B. Abdel-Naim   +11 more
doaj   +2 more sources

2-Methoxyestradiol as an Antiproliferative Agent for Long-Term Estrogen-Deprived Breast Cancer Cells [PDF]

Current Issues in Molecular Biology, 2023
To identify effective treatment modalities for breast cancer with acquired resistance, we first compared the responsiveness of estrogen receptor-positive breast cancer MCF-7 cells and long-term estrogen-deprived (LTED) cells (a cell model of endocrine ...
Masayo Hirao-Suzuki, Koki Kanameda, Masufumi Takiguchi, Narumi Sugihara, Shuso Takeda   +4 more
doaj   +2 more sources

Combination of quercetin and 2-methoxyestradiol inhibits epithelial–mesenchymal transition in PC-3 cell line via Wnt signaling pathway [PDF]

Future Science OA, 2021
Aim: We have previously reported that quercetin (Qu) regulates epithelial–mesenchymal transition (EMT) by modulating Wnt signaling components. In this study, we investigated the synergistic effect of Qu and 2-methoxyestradiol (2-ME) and the role of Wnt ...
Neeti Sharma, Piyush W Raut, Meghna M Baruah, Akshay Sharma   +3 more
doaj   +2 more sources