cJun-N-terminal kinase activity and mitosis perturbation drive the 2-methoxyestradiol-mediated enhancement of viral oncolysis by Epizootic Hemorrhagic Disease Virus-Tel Aviv University [PDF]
Scientific ReportsOncolytic viruses (OVs) are promising cancer therapies whose efficacy is restricted by tumor heterogeneity and monotherapy limitations. We investigated combining the oncolytic orbivirus Epizootic Hemorrhagic Disease Virus -Tel Aviv University (EHDV-TAU ...
Sucheta De +4 more
doaj +2 more sources
Correction to "Endogenous Hormone 2-Methoxyestradiol Suppresses Venous Hypertension-Induced Angiogenesis Through Up- and Down-Regulating p53 and ID-1". [PDF]
J Cell Mol MedJournal of Cellular and Molecular Medicine, Volume 30, Issue 7, April 2026.
europepmc +2 more sources
Urinary estrogen metabolites and gastric cancer risk among postmenopausal women
Cancer Reports, 2022 Background The overall incidence of gastric cancer in women is half that in men for most global populations. Sex hormone pathways may be involved in carcinogenesis and estrogens have been postulated to protect women against gastric cancer.
M. Constanza Camargo +18 more
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Combination of Quercetin and 2-Methoxyestradiol Enhances Inhibition of Human Prostate Cancer LNCaP and PC-3 Cells Xenograft Tumor Growth. [PDF]
PLoS ONE, 2015 Quercetin and 2-Methoxyestradiol (2-ME) are promising anti-cancer substances. Our previous in vitro study showed that quercetin synergized with 2-Methoxyestradiol exhibiting increased antiproliferative and proapoptotic activity in both androgen-dependent
Feiya Yang +5 more
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Synthesis, biological evaluation and molecular modeling of new analogs of the anti-cancer agent 2-methoxyestradiol: potent inhibitors of angiogenesis† [PDF]
RSC Advances, 2015 The synthesis, cytotoxicity, inhibition of tubulin polymerization and anti-angiogenic effects of 10 analogs of 2-methoxyestradiol are reported. These efforts revealed that the analog with a 4-pyridine ring in the 17-position, in combination with 2-ethyl-
Eirik Johansson Solum +4 more
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2‐Methoxyestradiol, a Promising Anticancer Agent [PDF]
Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy, 2003 Estrogens occurring naturally in the body are metabolized to catecholestrogens (2‐ and 4‐hydroxyestradiol) by the cytochrome P450 enzymes. 2‐Hydroxy catecholestrogens are further metabolized by catechol‐ O ‐methyltransferase to 2‐methoxyestradiol, which is known to be protective against tumor
Lakhani, Nehal J. +3 more
openaire +3 more sources
Molecules, 2022 A tetrahydroisoquinoline (THIQ) core is able to mimic the A and B rings of 2-methoxyestradiol (2ME2), an endogenous estrogen metabolite that demonstrates promising anticancer properties primarily by disrupting microtubule dynamic instability parameters ...
Scott D. Hargrave +5 more
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Central Interaction of 2-Methoxyestradiol and Lipoxygenase in AngII-Hypertension. [PDF]
HypertensionBACKGROUND: Our previous findings that arachidonic acid-12/15-lipoxygenase (LOX)-generated metabolite 12(S)-HETE contributes to angiotensin II (AngII)-induced hypertension and 17β-estradiol protects from AngII-induced hypertension via its cytochrome P450 (CYP)1B1-generated metabolite 2-methoxyestradiol in the paraventricular ...
Dutta SR +4 more
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, 2020 2-Methoxyestradiol is one of the natural 17β-estradiol derivatives and a potential novel anticancer agent currently being under evaluation in advanced phases of clinical trials.
Francesco Cappello +8 more
core +2 more sources
Biomolecules, 2020 In order to discover novel derivatives in the anti-tumor field, reported anti-tumor pharmacophores (uridine, uracil, and thymine) were combined with 2-methoxyestradiol, which has been characterized as having excellent biological properties in terms of ...
Li-Xin Sheng +5 more
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