2-Methoxyestradiol-bis-sulphamate refrains from inducing apoptosis and autophagy in a non-tumorigenic breast cell line [PDF]
Cancer Cell International, 2012 Background Anticancer research resulted in the discovery of a promising antimitotic metabolite, 2-methoxyestradiol. 2-Methoxyestradiol-bis-sulphamate, a bis-sulphamoylated analogue exerts antiproliferative- and antimitotic activity.
Visagie Michelle H, Joubert Anna M
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Molecules, 2014 Objective: 2-Methoxyestradiol, one of the natural 17β-estradiol derivatives, is a novel, potent anticancer agent currently being evaluated in advanced phases of clinical trials.
Magdalena Gorska +5 more
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Potential vascular actions of 2-methoxyestradiol [PDF]
Trends in Endocrinology & Metabolism, 2009 2-Methoxyestradiol (2-ME) is a biologically active metabolite of 17beta-estradiol that appears to inhibit key processes associated with cell replication in vitro. The molecule has been suggested to have potent growth-inhibitory effects on proliferating cells, including smooth muscle cells and endothelial cells, and may be antiangiogenic.
Dubey, R K, Jackson, E K
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2-Methoxyestradiol Inhibits Radiation-Induced Skin Injuries. [PDF]
Int J Mol Sci, 2022 Radiation-induced skin injury (RISI) is a main side effect of radiotherapy for cancer patients, with vascular damage being a common pathogenesis of acute and chronic RISI. Despite the severity of RISI, there are few treatments for it that are in clinical use.
Kim JH +7 more
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2-Methoxyestradiol, an Endogenous 17β-Estradiol Metabolite, Induces Antimitogenic and Apoptotic Actions in Oligodendroglial Precursor Cells and Triggers Endoreduplication via the p53 Pathway [PDF]
CellsThe abnormal growth of oligodendrocyte precursor cells (OPCs) significantly contributes to the progression of glioblastoma tumors. Hence, molecules that block OPC growth may be of therapeutic importance in treating gliomas.
Sara. A. Schaufelberger +5 more
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Regulation of mitochondrial dynamics in 2-methoxyestradiol-mediated osteosarcoma cell death [PDF]
Scientific Reports, 2021 Osteosarcoma (OS) is one of the most malignant tumors of childhood and adolescence. Research on mitochondrial dynamics (fusion/fission) and biogenesis has received much attention in last few years, as they are crucial for death of cancer cells ...
Magdalena Gorska-Ponikowska +8 more
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2-methoxyestradiol inhibits the malignant behavior of triple negative breast cancer cells by altering their miRNome [PDF]
Frontiers in OncologyBackgroundTriple-negative breast cancer (TNBC) is a subtype of breast cancer with no effective targeted treatment currently available. Estrogen and its metabolites influence the growth of mammary cancer.
Ramadevi Subramani +9 more
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Frontiers in Cellular Neuroscience, 2022 ObjectiveNumerous studies have shown that neuroinflammation and brain edema play an important role in early brain injury (EBI) after subarachnoid hemorrhage (SAH).
Qiang Hu +8 more
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GLUT-Targeted Adhesive Nanoparticles Enhance the Oral Absorption and Anti-Tumor Effects of 2-Methoxyestradiol [PDF]
International Journal of NanomedicineYabing Xing,1 Wentao Hu,2 Yuxin Li,2 Yuru Zhang,2 Yulu Zhang,2 Binghua Wang,2,3 Xinhong Guo2,3 1Department of Pharmacy, Children’s Hospital Affiliated to Zhengzhou University, Zhengzhou, Henan, People’s Republic of China; 2School of Pharmaceutical ...
Xing Y +6 more
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Inhibition of STAT3 by 2-Methoxyestradiol suppresses M2 polarization and protumoral functions of macrophages in breast cancer [PDF]
BMC CancerBackground Breast cancer metastasis remains the leading cause of cancer-related deaths in women worldwide. Infiltration of tumor-associated macrophages (TAMs) in the tumor stroma is known to be correlated with reduced overall survival.
Bhawna Deswal +4 more
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