Results 31 to 40 of about 97,768,097 (202)

The Potential and Suitability of 2-Methoxyestradiol in Cancer Therapy [PDF]

Clinical Cancer Research, 2005
To the Editor: We disagree with the conclusions in a recent article by Sutherland et al. ([1][1]) stating that 2-methoxyestradiol (2ME2) is an unsuitable antitumor agent that lacks efficacy and has estrogen receptor–dependent and estrogen receptor–independent adverse effects.
Sidor, C, D'Amato, R, Miller, KD
openaire   +3 more sources

Proteasome inhibitors modulate anticancer and anti-proliferative properties via NF-kB signaling, and ubiquitin-proteasome pathways in cancer cell lines of different organs

Lipids in Health and Disease, 2018
Background Cancer is second most common cause of death in the United State. There are over 100 different types of cancer associated with different human organs, predominantly breast, liver, pancreas, prostate, colon, rectum, lung, and stomach.
Asaf A. Qureshi, Eleanor G. Zuvanich, Dilshad A. Khan, Shahida Mushtaq, Neerupma Silswal, Nilofer Qureshi   +5 more
doaj   +1 more source

Regulation of interferon pathway in 2-methoxyestradiol-treated osteosarcoma cells

BMC Cancer, 2012
Background Osteosarcoma is a bone tumor that often affects children and young adults. Although a combination of surgery and chemotherapy has improved the survival rate in the past decades, local recurrence and metastases still develop in 40% of patients.
Wimbauer Fritz, Yang Caihong, Shogren Kristen L, Zhang Minzhi, Goyal Ribu, Riester Scott M, Yaszemski Michael J, Maran Avudaiappan   +7 more
doaj   +1 more source

Efficacy of Intravitreal injection of 2-Methoxyestradiol in regression of neovascularization of a retinopathy of prematurity rat model

BMC Ophthalmology, 2017
Background Retinopathy of prematurity (ROP) is one of the targets for early detection and treatment to prevent childhood blindness in world health organization programs.
Azza Mohamed Ahmed Said, Rania Gamal Eldin Zaki, Rania A. Salah Eldin, Maha Nasr, Samar Saad Azab, Yaser Abdelmageuid Elzankalony   +5 more
doaj   +1 more source

Effect of Interaction between Chromium(VI) with 17β-Estradiol and Its Metabolites on Breast Cancer Cell Lines MCF-7/WT and MDA-MB-175-VII: Preliminary Study

Molecules, 2023
The number of factors initiating and stimulating the progression of breast cancer are constantly increasing. Estrogens are a risk factor for breast adenocarcinoma, the toxicity of which increases as a result of metabolism and interaction with other ...
Ewa Sawicka, Julita Kulbacka, Małgorzata Drąg-Zalesińska, Arkadiusz Woźniak, Agnieszka Piwowar   +4 more
doaj   +1 more source

In vitro influence of 2-methoxyestradiol-bis-sulphamate on cell numbers, reactive oxygen species production and autophagy induction in a breast adenocarcinoma- and a non tumorigenic breast epithelial cell line [PDF]

, 2012
This study indicates that 2-methoxyestradiol-bissulphamate induces both apoptosis and autophagy and contributes to the unraveling of the action mechanism of 2-methoxyestradiol-bis-sulphamate.http://www.satnt.ac ...
Joubert, Annie M., Visagie, M.H. (Michelle Helen)   +1 more
core   +1 more source

Immunomodulation by the estrogen metabolite 2-methoxyestradiol

Clinical Immunology, 2014
2-methoxyestradiol (2me2), a metabolite of 17β-estradiol (E2), has been tested in phase II clinical cancer trials and models of inflammation. Its effects are only partly clarified. We investigated the effects of 2me2 on the immune system, using ovariectomized or sham-operated mice treated with a high and a low dose of 2me2 (2me2H and 2me2L), E2 or ...
Stubelius, Alexandra, Erlandsson, Malin C., Islander, Ulrika, Carlsten, Hans   +3 more
openaire   +2 more sources

Inhibition of 2-methoxyestradiol glucuronidation by probenecid

Journal of Pharmacy and Pharmacology, 2015
AbstractObjectives2-Methoxyestradiol (2ME2), a metabolite of estradiol, has antitumour activity in vitro. However, potential clinical applicability has been limited by low oral bioavailability. Probenecid was evaluated in vitro as an inhibitor of 2ME2 glucuronidation for purposes of enhancing 2ME2 oral bioavailability.MethodsHuman liver microsomes were
Yuli, Qian, Ahmad, Sherbini, Bahar, Matin, Yanli, Zhao, John, Castellot, David J, Greenblatt   +5 more
openaire   +2 more sources

2-Methoxyestradiol and its derivatives inhibit store-operated Ca2+ entry in T cells: identification of a new and potent inhibitor [PDF]

, 2021
T cell activation starts with formation of second messengers that release Ca2+ from the endoplasmic reticulum (ER) and thereby activate store-operated Ca2+ entry (SOCE), one of the essential signals for T cell activation.
Tolosa, Eva, Flügel, Alexander, Marry, Stephen, Bauche, Andreas, Odoardi, Francesca, Guse, Andreas H, Löhndorf, Anke, Windhorst, Sabine, Hosang, Leon, Waschkowski, Sissy-Alina, Winzer, Riekje, Diercks, Björn-Philipp, Dohle, Wolfgang, Rosche, Anette, Potter, Barry VL, Guse, Andreas H., Anette Rosche, Eva Tolosa, Anke Löhndorf, Wolfgang Dohle, Leon Hosang, Sissy-Alina Waschkowski, Björn-Philipp Diercks, Barry V.L. Potter, Alexander Flügel, Stephen Marry, Francesca Odoardi, Andreas Bauche, Riekje Winzer, Andreas H. Guse, Sabine Windhorst   +30 more
core   +1 more source

2-Methoxyestradiol: New perspectives in colon carcinoma treatment [PDF]

Molecular and Cellular Endocrinology, 2011
Colon carcinoma represents a major problem in oncology, since this type of cancer responds poorly to conventional chemotherapy. Many groups are actively involved in the search of new experimental strategies to bypass this problem. We investigated the effects of 2-methoxyestradiol (2-ME), which derives from the NADPH-dependent cytochrome P450 metabolism
Parks M, Tillhon M, Donà F, Prosperi E, Scovassi AI   +4 more
openaire   +3 more sources