Results 51 to 60 of about 97,768,097 (202)

2-Methoxyestradiol Protects Against Lung Ischemia/Reperfusion Injury by Upregulating Annexin A1 Protein Expression

Frontiers in Immunology, 2021
Background: 2-Methoxyestradiol (2ME), a natural 17-β estradiol metabolite, is a potent anti-inflammatory agent, but its effect on ischemia/reperfusion (IR)-induced acute lung inflammation remains unknown.
Wen-I Liao, Wen-I Liao, Shu-Yu Wu, Shih-Hung Tsai, Shih-Hung Tsai, Hsin-Ping Pao, Kun-Lun Huang, Kun-Lun Huang, Shi-Jye Chu   +8 more
doaj   +1 more source

Mitochondria as the Hub of Apoptosis: A Comprehensive Insight From Mitochondria to Interactions With Other Organelles

MedComm, Volume 7, Issue 9, September 2026.
Mitochondria is the hub of apoptosis in various diseases. The disruption of mitochondrial structure (including membrane rupture, cristae remodeling, and mitochondrial membrane lipid redistribution), the imbalance of mitochondrial dynamics (including fusion and fission, autophagy), the release, disruption, and mutation of mitochondria DNA, as well as ...
Rubin Tan, Jinming Zhao, Rong Wang, Yue Shi, Zaozao Chen, Yixuan Ma, Na Li, Wenqing Duan, Duo Lin, Chunxiang Zhang   +9 more
wiley   +1 more source

Synthesis and in Vivo Antitumor Evaluation of 2-Methoxyestradiol 3-Phosphate, 17-Phosphate, and 3,17-Diphosphate

, 2016
A prodrug strategy was investigated to address the problem of limited aqueous solubility and the resulting limited bioavailability of the antitumor agent 2-methoxyestradiol.
Wei Song (30780), Allison B. Edsall (2461183), Mark Cushman (115145), Stacy M. Plum (2461192), Gregory E. Agoston (2436067), Anthony M. Treston (2461189), Tian-Sheng Lu (2461195), Robert H. McClanahan (2461186)   +7 more
core   +1 more source

Rational Design of Organic Chromophores for Simultaneously Triggering Redox Imbalance and Tracking Organelles in Biological Systems Under Near‐Infrared Light Irradiation

Advanced Healthcare Materials, Volume 15, Issue 31, 21 August 2026.
TOC represents the synthesis of theory‐guided novel near‐infrared (NIR) light‐absorbing organic photosensitizers (OPS) enabling redox‐induced tumor phototherapy and single‐cell organelle tracking. ABSTRACT The design of organic photosensitizers that operate efficiently in the near‐infrared (NIR) region remains challenging due to the need to balance ...
Pragti, Bidyut Kumar Kundu, Jiajie Diao, Yujie Sun   +3 more
wiley   +1 more source

Decreased expression of HN1 sensitizes prostate cancer cells to apoptosis induced by Docetaxel and 2-Methoxyestradiol

, 2022
Objective: Prostate cancer is one of the most frequently diagnosed cancer in men and ranks as the second most common cause of cancer-related deaths in developed countries.
Varışli, Lokman
core   +3 more sources

Carbon dots-enhanced luminol chemiluminescence and its application to 2-methoxyestradiol determination

Green Chemistry Letters and Reviews, 2018
In this study, the fluorescent carbon dots (CDs) of good biocompatibility and low toxicity was prepared by a carbonation route, and a strong enhancement effect of CDs on the luminol-K3Fe(CN)6 chemiluminescence (CL) system was observed.
Min Zhang, Yulei Jia, Jianhua Cao, Guanghui Li, Huacheng Ren, Hui Li, Hanchun Yao   +6 more
doaj   +1 more source

Obstructive Sleep Apnea: Epidemiology, Pathophysiology, Complications, Diagnosis, Management, and Emerging Fibrosis‐Linked Remodeling

MedComm, Volume 7, Issue 8, August 2026.
Obstructive sleep apnea (OSA) is characterized by recurrent upper‐airway collapse, which generates key nocturnal stressors including intermittent hypoxia, sleep fragmentation, intrathoracic pressure stress, and sympathetic activation. These physiological disturbances converge on shared biological mechanisms, including oxidative stress, inflammation ...
Nhi Ho Thi Thuy, Thị Hằng Giang Phan, Ali Hussein Eid, Paola Maccioccu, Stefania Camboni, Gavino Casu, Anna Maria Posadino, Roberta Giordo, Gianfranco Pintus   +8 more
wiley   +1 more source

Sulphamoylated 2-methoxyestradiol analogues induce apoptosis in adenocarcinoma cell lines.

PLoS ONE, 2013
2-Methoxyestradiol (2ME2) is a naturally occurring estradiol metabolite which possesses antiproliferative, antiangiogenic and antitumor properties. However, due to its limited biological accessibility, synthetic analogues have been synthesized and tested
Michelle Visagie, Anne Theron, Thandi Mqoco, Warren Vieira, Renaud Prudent, Anne Martinez, Laurence Lafanechère, Annie Joubert   +7 more
doaj   +1 more source

Exploring Resistance to ETS Targeting Agents in Diffuse Large B‐Cell Lymphoma

Cancer Medicine, Volume 15, Issue 5, May 2026.
This study provides the first systematic characterization of resistance to ETS inhibition in diffuse large B‐cell lymphoma (DLBCL). Using TK216‐resistant models, we reveal heterogeneous escape mechanisms, including MDR1 upregulation, transcriptional reprogramming, and cytoskeletal remodeling, each associated with distinct mutational signatures ...
Filippo Spriano, Luciano Cascione, Chiara Tarantelli, Giulio Sartori, Alberto J. Arribas, Adriana Velasova, Sara Napoli, Ondrej Havranek, Jeffrey A. Toretsky, Francesco Bertoni   +9 more
wiley   +1 more source

Candidate Genes and Mechanisms for 2-Methoxyestradiol–Mediated Vasoprotection [PDF]

Hypertension, 2010
2-Methoxyestradiol (2-ME; estradiol metabolite) inhibits vascular smooth muscle cell (VSMC) growth and protects against atherosclerosis and vascular injury; however, the mechanisms by which 2-ME induces these actions remain obscure. To assess the impact of 2-ME on biochemical pathways regulating VSMC biology, we used high-density oligonucleotide ...
Barchiesi, F, Lucchinetti, E, Zaugg, M, Ogunshola, O O, Wright, M, Meyer, Markus, Rosselli, M, Schaufelberger, S, Gillespie, D G, Jackson, E K, Dubey, R K   +10 more
openaire   +5 more sources