Results 71 to 80 of about 97,768,097 (202)

Molecular Mechanism of Mulberrin Regulating Lipid Metabolism Homeostasis Based on the Gut–Liver Axis Fiaf/AMPK Signaling Pathway

Food Frontiers, Volume 7, Issue 2, March 2026.
The molecular mechanism for mulberrin regulating lipid metabolism homeostasis. ABSTRACT Lipid metabolism disorders and the induced metabolic diseases have risen to become one of the primary public health issues. Our preliminary experimental results confirmed that mulberry leaf flavonoid extract exhibited efficacy in lipid metabolism regulation; the ...
Qian Li, Daorui Pang, Erna Li, Dongxu Xing, Fan Liu, Li Wang, Yuxiao Zou   +6 more
wiley   +1 more source

Pro-apoptotic and anti-angiogenic actions of 2-methoxyestradiol and docosahexaenoic acid, the biologically derived active compounds from flaxseed diet, in preventing ovarian cancer

Journal of Ovarian Research, 2019
Background We have previously shown that a whole flaxseed supplemented diet decreased the onset and severity of ovarian cancer in the laying hen, the only known animal model of spontaneous ovarian cancer.
Purab Pal, Karen Hales, Jim Petrik, Dale Buchanan Hales   +3 more
doaj   +1 more source

Estrone‐α‐2‐Deoxy‐Glucoside as a Targeted Therapy for Triple‐Negative Breast Cancer: Aromatase Inhibition and Cytotoxicity

Chemical Biology &Drug Design, Volume 107, Issue 2, February 2026.
Estrone‐α‐2DG, synthesized via a one‐pot multi‐enzyme system, selectively inhibits aromatase (IC50 = 0.101μM) and triple negative breast cancer cells (IC50 = 20.46 μM), offering a dual function therapeutic scaffold. ABSTRACT Aromatase inhibitors (AIs) are vital in the treatment of estrogen‐dependent breast cancer, especially in postmenopausal women. In
Tzu‐Yu Huang, Meng‐Ru Wang, Feng‐Pai Chou, Sheng‐Cih Huang, Po‐Yun Hsiao, Tung‐Kung Wu   +5 more
wiley   +1 more source

Endobiota–Estrobolome Profiles in Reproductive‐Aged Women With Ovarian Endometriosis

Reproductive Medicine and Biology, Volume 25, Issue 1, January/December 2026.
ABSTRACT Purpose This case–control study investigated whether ovarian endometriosis is associated with altered estrogen metabolism and gut or urogenital microbiota by analyzing enzyme activity, bacterial composition, and variations of estrogen metabolites in fecal, vaginal, and urinary samples. Methods Thirty‐eight reproductive‐aged women were enrolled,
Chia‐Yu Hu, Angel Hsin‐Yu Pai, Yi‐Wen Wang, Pei‐Chen Lu, Hsien‐Ming Wu, Hong‐Yuan Huang   +5 more
wiley   +1 more source

Taohong Siwu Decoction Regulates MSC‐Mediated H‐Type Angiogenesis to Accelerate Bone Fracture Healing Through VHL/HIF‐1α Ubiquitination

Mediators of Inflammation, Volume 2026, Issue 1, 2026.
Background Bone fracture healing is a multifaceted process that involves different stages and intercellular interactions. In this study, we aimed to investigate the effect of Taohong Siwu decoction (TSD) on bone fracture healing and the underlying mechanisms.
Wangyang Li, Zebing Ma, Peng He, Wuji Xu, Xiaolan Liu, Jinlong Yao, Qiyao Wu, Pinglan Zou, Tiao Li, Yao Luo   +9 more
wiley   +1 more source

A Short, Economical Synthesis of 2-Methoxyestradiol, an Anticancer Agent in Clinical

, 2016
2-Methoxyestradiol, a natural metabolite of estradiol and potential therapeutic agent for many types of cancers, has been synthesized successfully in three steps, starting from estradiol and cumyl methyl ...
Mercy Akomeah (2354923), Cal Y. Meyers (2354926), Yuqing Hou (725544)   +2 more
core   +1 more source

Data‐driven discovery of gene expression markers distinguishing pediatric acute lymphoblastic leukemia subtypes

Molecular Oncology, Volume 19, Issue 12, Page 3548-3577, December 2025.
This study investigates gene expression differences between two major pediatric acute lymphoblastic leukemia (ALL) subtypes, B‐cell precursor ALL, and T‐cell ALL, using a data‐driven approach consisting of biostatistics and machine learning methods. Following analysis of a discovery dataset, we find a set of 14 expression markers differentiating the ...
Mona Nourbakhsh, Nikola Tom, Anna Schrøder Lassen, Helene Brasch Lind Petersen, Ulrik Kristoffer Stoltze, Karin Wadt, Kjeld Schmiegelow, Matteo Tiberti, Elena Papaleo   +8 more
wiley   +1 more source

4-(7-Acetoxy-6-methoxy-4-methyl-2-oxo-2H-chromen-3-yl)phenyl acetate

Acta Crystallographica Section E, 2008
The title compound, C21H18O7, is an important intermediate in the synthesis of 3-(4-hydroxyphenyl)-4-methyl-6-methoxy-7-hydroxycoumarin, which is a nonsteroidal analogue of 2-methoxyestradiol (2-ME).
Hao Jiang, Peng Xia, Qian Zhang
doaj   +1 more source

Effect of Interaction between 17β-Estradiol, 2-Methoxyestradiol and 16α-Hydroxyestrone with Chromium (VI) on Ovary Cancer Line SKOV-3: Preliminary Study

Molecules, 2020
Ovarian cancer is the leading cause of death from gynecologic malignancies. Some estrogens, as well as xenoestrogens, such as chromium (VI) (Cr(VI)), are indicated as important pathogenic agents.
Ewa Sawicka, Jolanta Saczko, Joanna Roik, Julita Kulbacka, Agnieszka Piwowar   +4 more
doaj   +1 more source

Activation and Regioselective Ortho-Functionalization of the A-Ring of β-Estradiol Promoted by “Cp*Ir”:  An Efficient Organometallic Procedure for the Synthesis of 2-Methoxyestradiol

, 2016
5,6,7,8-Tetrahydro-2-naphthol (3) and β-estradiol (1) gave η6-arene complexes using [Cp*Ir(solvent)3][BF4]2 (4) prepared in situ; subsequent O-deprotonation with NEt3 produced the corresponding complexes [Cp*Ir(oxo-η5-dienyl)][BF4] (5 and 6a,b).
M. N. Rager (2977764), J. Vaissermann (2953266), H. Amouri (2459446), Y. Besace (2977767), J. Le Bras (2976438)   +4 more
core   +1 more source