Results 91 to 100 of about 97,768,097 (202)

Isoxazole‐Based Compounds Targeting the Taxane‐Binding Site of Tubulin

Archiv der Pharmazie, Volume 358, Issue 7, July 2025.
Lead compound 2j targets the taxane site of tubulin with a nanomolar KD and induces G2/M block by mitotic arrest at low micromolar doses. Prolonged mitotic arrest led to the induction of apoptosis in cancer cells, also in docetaxel‐resistant prostate cancer cells, suggesting its potential in taxane‐resistant cancer therapy.
Miroslav Peřina, Márton A. Kiss, Jakub Bělíček, Veronika Vojáčková, Denisa Veselá, Renáta Minorics, István Zupko, Éva Frank, Radek Jorda   +8 more
wiley   +1 more source

Effects of Hormone Deprivation, 2-Methoxyestradiol Combination Therapy on Hormone-Dependent Prostate Cancer In Vivo

Neoplasia: An International Journal for Oncology Research, 2005
2-Methoxyestradiol (2-ME) has potent anti proliferative effects on cancer cells. Its utility alone or in combination with other therapies for treating prostate cancer, however, has not been fully explored.
Fuminori Sato, Hiroshi Fukuhara, James P. Basilion   +2 more
doaj   +1 more source

Supplementary Data from 2-Methoxyestradiol Inhibits Barrett's Esophageal Adenocarcinoma Growth and Differentiation through Differential Regulation of the β-Catenin–E-Cadherin Axis

, 2010
Supplementary Data from 2-Methoxyestradiol Inhibits Barrett's Esophageal Adenocarcinoma Growth and Differentiation through Differential Regulation of the β-Catenin–E-Cadherin ...
Monami Majumder (15040811), Gibanananda Ray (127080), Suman Kambhampati (433292), Kakali Dhar (14885388), Inamul Haque (446324), Smita Mehta (15040808), Sushanta K. Banerjee (9605489), Peter J. Vanveldhuizen (15040814), Gopal Dhar (8394876), Snigdha Banerjee (433288)   +9 more
core   +1 more source

Glutamine Metabolism: Molecular Regulation, Biological Functions, and Diseases

MedComm, Volume 6, Issue 7, July 2025.
Tumor cells adapt to nutrient‐poor environments by altering metabolism to acquire essential nutrients. They convert glutamine into glutamate and α‐ketoglutarate, supporting mTOR activation and sugar biosynthesis. Disruption of mTORC1 signaling is linked to disease, while glutamine and leucine activation promotes cell growth and inhibits autophagy ...
Mudasir A. Kumar, Sana Khurshid Baba, Inamu Rashid Khan, Mohd Shahnawaz Khan, Fohad Mabood Husain, Saheem Ahmad, Mohammad Haris, Mayank Singh, Ammira S. Al‐Shabeeb Akil, Muzafar A. Macha, Ajaz A. Bhat   +10 more
wiley   +1 more source

Influence of 2-methoxyestradiol on MCF-7 cells : an improved differential interference contrasting technique and Bcl-2 and Bax protein expression levels [PDF]

, 2009
Proteins of the B-cell lymphoma 2 family are crucial for the regulation of apoptosis. B-cell lymphoma 2-associated X is a pro-apoptotic protein, while B-cell lymphoma 2 protein opposes apoptosis. The influence of 1 μM 2-methoxyestradiol was investigated
Maritz, Christine, Marais, Sumari, Joubert, Annie M.   +2 more
core  

2-methoxyestradiol inhibits hypoxia-inducible factor-1{alpha} and suppresses growth of lesions in a mouse model of endometriosis.

, 2016
Endometriosis, the presence of ectopic endometrial tissue outside the uterine cavity, is a common disease affecting women during their reproductive years.

core   +1 more source

Mitochondrial Transplantation: A Novel Therapeutic Approach for Treating Diseases

MedComm, Volume 6, Issue 6, June 2025.
This article describes the roles of mitochondria in health and disease and reviews the effects of mitochondrial transplantation in disease, including restoring ATP production, attenuating oxidative stress, modulating inflammatory responses, reducing apoptosis, promoting cell repair, and exhibiting antitumor properties.
Xinglu Miao, Pei Jiang, Zhaoping Wang, Weihua Kong, Lei Feng   +4 more
wiley   +1 more source

Dynamic change of estrogen and progesterone metabolites in human urine during pregnancy

Scientific Reports
Endogenous estrogen and progesterone and their metabolites play a key role in regulating and maintaining the normal pregnancy process. However, the dynamic change of these estrogen and progesterone metabolites’ level across the entire gestational period ...
Chen Jin, Ying Peng, Xiaoyan Luo, Qi Zhu, Langqi Lin, Jinying Yang, Pan Wang   +6 more
doaj   +1 more source

Antitumor effect of 2-methoxyestradiol in a rat orthotopic brain tumor model.

, 2006
Grade 4 malignant glioma (GBM) is a fatal disease despite aggressive surgical and adjuvant therapies. The hallmark of GBM tumors is the presence of pseudopalisading necrosis and microvascular proliferation.
Cho, HT, Liang, Z, Lavallee, TM, Escuin, D, Brat, DJ, Shim, H, Simons, JW, Zhang, Z, Kang, SH, Mao, H, Giannakakou, P, Devi, S, Van Meir, EG, Olson, JJ   +13 more
core   +1 more source

Video Legends.Supplementary Table 1. Supplementary Figure 5 from ENMD-1198, a New Analogue of 2-Methoxyestradiol, Displays Both Antiangiogenic and Vascular-Disrupting Properties

, 2010
Video Legends.Supplementary Table 1. Supplementary Figure 5 from ENMD-1198, a New Analogue of 2-Methoxyestradiol, Displays Both Antiangiogenic and Vascular-Disrupting ...
Snega Sinnappan (15041654), Marcia A. Munoz (7235780), Eddy Pasquier (250721), Maria Kavallaris (54201)   +3 more
core   +1 more source