Results 101 to 110 of about 97,768,097 (202)

Evaluation of the Combined Effect of 2ME2 and Co on the Inducement of DNA Damage by IUdR in a Spheroid Model of the U87MG Glioblastoma Cancer Cell Line Using Alkaline Comet Assay [PDF]

Cell Journal, 2011
Objective: In this study, we investigated the combined effect of 2-Methoxyestradiol (2ME2)and 60Co on the cytogenetic damage of iododeoxyuridine (IUdR) in the spheroid model ofU87MG glioblastoma cancer cell lines by alkaline comet assay.Materials and ...
Ali Neshasteh-Riz, Seyed Rabi Mahdavi, Samideh Khoei, Sara Delfan   +3 more
doaj  

2-Methoxyestradiol mediated signaling network in pancreatic cancer

Frontiers in Bioscience, 2009
2-Methoxyestradiol (2-ME), an endogenous metabolite of 17 beta-estradiol, is known to be a potent inhibitor of neovascularization. Our previous studies have shown that 2-ME can suppress growth of pancreatic tumor cells in vitro and in vivo by the induction of apoptosis (Cancer Res 66: 4309-18, 2006).
Aruna, Basu, Subrata, Haldar
openaire   +2 more sources

Novel sulphamoylated 2-methoxy estradiol derivatives inhibit breast cancer migration by disrupting microtubule turnover and organization

Cancer Cell International, 2019
Background The estrogen metabolite 2-methoxyestradiol (2ME2) and a number of synthesised derivatives have been shown to bind to microtubules thereby arresting cancer cells in mitosis which leads to apoptosis.
Rustelle Janse van Vuuren, Mandie Botes, Tamarin Jurgens, Anna Margaretha Joubert, Iman van den Bout   +4 more
doaj   +1 more source

Influence of 2‐Methoxyestradiol and Sex on Hypoxia‐Induced Pulmonary Hypertension and Hypoxia‐Inducible Factor‐1‐α

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2019
Background Women are at greater risk of developing pulmonary arterial hypertension, with estrogen and its downstream metabolites playing a potential role in the pathogenesis of the disease.
Craig K. Docherty, Margaret Nilsen, Margaret R. MacLean   +2 more
doaj   +1 more source

Endogenous estrogen metabolites as oxidative stress mediators and endometrial cancer biomarkers

Cell Communication and Signaling
Background Endometrial cancer is the most common gynecologic malignancy found in developed countries. Because therapy can be curative at first, early detection and diagnosis are crucial for successful treatment.
Katarzyna Bukato, Tomasz Kostrzewa, Antonella Marino Gammazza, Magdalena Gorska-Ponikowska, Sambor Sawicki   +4 more
doaj   +1 more source

In vitro effects of 2-methoxyestradiol-bis-sulphamate on reactive oxygen species and possible apoptosis induction in a breast adenocarcinoma cell line

Cancer Cell International, 2011
Background In the search for anticancer agents, a promising 17-β-estradiol metabolite, 2-methoxyestradiol (2ME2) was found that exerts antiproliferative in vitro and in vivo activity.
Visagie Michelle H, Joubert Anna M
doaj   +1 more source

A new micronized formulation of 2-methoxyestradiol-bis-sulfamate (STX140) is therapeutically potent against breast cancer

, 2008
There is a continued need for orally bioavailable anticancer compounds that exhibit good efficacy against breast cancer. STX140, a derivative of 2-methoxyestradiol (2-MeOE2), has been shown to have excellent oral bioavailability and significantly reduces
Leese, Mathew P, Diolez, Christian, Newman, Simon P, Ali, Tauhid, Baronnet, Marie-Madeleine, Potter, Barry V L, Foster, Paul A, Reed, Michael J, Purohit, Atul, Camara, Jose, Hacher, Beatrice, Bernetiere, Sonia   +11 more
core   +3 more sources

2-methoxyestradiol impacts on amino acids-mediated metabolic reprogramming in osteosarcoma cells by interaction with NMDA receptor

, 2017
Deregulation of serine and glycine metabolism, have been identified to function as metabolic regulators in supporting tumor cell growth. The role of serine and glycine in regulation of cancer cell proliferation is complicated, dependent on concentrations
Kuban Jankowska, A., LO BOSCO, Giosue', Giosuè Lo Bosco, Giampaolo Barone, Ugo Perricone, Magdalena Gorska-Ponikowska, Gorska Ponikowska, Magdalena, Perricone, Ugo, BARONE, Giampaolo, Alicja Kuban-Jankowska   +9 more
core   +1 more source

Therapeutic Efficacy of 2-Methoxyestradiol Microcrystals Encapsulated within Polyelectrolyte Multilayers [PDF]

, 2009
Development of a novel formulation of anticancer drugs to improve their water-solubility and bioavailability remains a great challenge. Herein, the potential anticancer agent 2-methoxyestradiol (2-ME) was selected as a model drug and was encapsulated ...
Shi, Xiangyang, Baker, James R. Jr., James R. Baker, Wang, Su He, Xisui Chen, Su He Wang, Chen, Xisui, Xiangyang Shi   +7 more
core   +1 more source

Evaluation of the cancer specificity of intracellular events caused by 2-methoxyestradiol-bis-sulphamate and aqueous Sutherlandia frutescens extracts [PDF]

, 2013
This paper was initially delivered at the Annual Congress of the Biological Sciences Division of the South African Academy for Science and Art, ARC-Plant Protection Research Institute, Roodeplaat, Pretoria, South Africa on 01 October 2010.This study ...
Vorster, C.J.J. (Christiaan Jacob Johan), Joubert, Annie M.   +1 more
core   +1 more source