Results 81 to 90 of about 97,768,097 (202)

Transcriptomics Guided Engineering of Exosome‐Encapsulated Bifunctional Nanosheets Targeting the Immune‐PI3K/Akt Axis for Osteoporosis Therapy

Advanced Science, Volume 12, Issue 47, December 18, 2025.
A multifunctional nanosheet–exosome hybrid system incorporating f‐CA(OH) nanosheets enriched with abundant surface vacancies are developed. These nanosheets fuse with natural exosomes, endowing them with nanozyme‐like catalytic capabilities while retaining their inherent biological functions.
Rongze Tang, Guanhong Liu, Congcong Wang, Minghao Chao, Guangyu Ma, Pengjin Wei, Siling Du, Junjie Li, Yufan Liu, Chaonan Jing, Guoquan Wu, Ming Guan, Hongliang Chen, Fenglei Gao   +13 more
wiley   +1 more source

PFKFB2‐Driven Glycolysis Promotes Dendritic Cell Maturation and Exacerbates Acute Lung Injury

Advanced Science, Volume 12, Issue 37, October 6, 2025.
Paraquat (PQ) or lipopolysaccharide (LPS) exposure activates the HIF‐1α–PFKFB2 pathway, driving glycolysis in dendritic cells (DCs). This metabolic shift enhances DC maturation and immune activation, exacerbating acute lung injury (ALI). This study demonstrates that PFKFB2‐driven glycolytic reprogramming in DCs plays a critical role in the pathogenesis
Ding Yuan, Fang Yang, Linlin Hou, Yan Zhang, Xin Pang, Yuqi Du, Hongyi Yan, Huanzhou Zhu, Yue Cheng, Yue Wu, Pinpin Jiang, Mengnan Guo, Mengying Zhang, Jinjie Guo, Huihui Hao, Yong Jiang, Yi Li, Yanxia Gao   +17 more
wiley   +1 more source

Imaging microtubule dynamics: A new frontier in biomarker development for neurodegenerative diseases

Alzheimer's &Dementia, Volume 21, Issue 9, September 2025.
Abstract Microtubules (MTs) are essential components of the neuronal cytoskeleton, playing key roles in intracellular transport, synaptic function, and overall neuronal integrity. Although MT dynamics and MT‐binding agents have been studied extensively, their potential as biomarkers in neurodegenerative diseases has received limited attention. Emerging
Naresh Damuka, Samuel N. Lockhart, Kiran K. Solingapuram Sai   +2 more
wiley   +1 more source

Preparation and evaluation of 2-methoxyestradiol-loaded pH-sensitive liposomes

Brazilian Journal of Pharmaceutical Sciences
The development and clinical application of 2-methoxyestradiol (2-ME) as a new type of antitumor drug are limited due to its poor solubility, rapid metabolism in vivo, and large oral dosage.
Suna He, Bowen Wang, Runfang Zhang, Huanhuan Zhou, Qian Yang   +4 more
doaj   +1 more source

Inclusion complexes of 2-methoxyestradiol with dimethylated and permethylated β-cyclodextrins: models for cyclodextrin–steroid interaction

Beilstein Journal of Organic Chemistry, 2015
The interaction between the potent anticancer agent 2-methoxyestradiol (2ME) and a series of cyclodextrins (CDs) was investigated in the solid state using thermal analysis and X-ray diffraction, while the possibility of enhancing its poor aqueous ...
Mino R. Caira, Susan A. Bourne, Halima Samsodien, Vincent J. Smith   +3 more
doaj   +1 more source

The endogenous estradiol metabolite 2-methoxyestradiol reduces atherosclerotic lesion formation in female apolipoprotein E-deficient mice

, 2007
Estradiol, the major endogenous estrogen, reduces experimental atherosclerosis and metabolizes to 2-methoxyestradiol in vascular cells. Currently undergoing evaluation in clinical cancer trials, 2-methoxyestradiol potently inhibits cell proliferation ...
Borén, Jan,, Tivesten, Åsa,, Fagman, Johan Bourghardt,, Bergström, Göran,, Krettek, Alexandra,, Sjöberg, Sara,, Bourghardt, Johan,   +6 more
core   +1 more source

The estrobolome: Estrogen‐metabolizing pathways of the gut microbiome and their relation to breast cancer

International Journal of Cancer, Volume 157, Issue 4, Page 599-613, 15 August 2025.
Abstract Increasing evidence links the gut microbiome to carcinogenesis. Disruptions in estrogen regulation by the estrobolome—gut microbiota with estrogen‐related functions—may promote breast cancer. However, precise information on estrobolome targets and their underlying mechanisms is limited. This review identifies relevant targets for measuring the
Ashley H. Larnder, Amee R. Manges, Rachel A. Murphy   +2 more
wiley   +1 more source

A “one-two punch” strategy to reverse immunosuppressive metabolism and activate T-cell immunity for enhanced cancer checkpoint immunotherapy

Journal of Nanobiotechnology
Immune checkpoint blockade therapy, represented by CTLA-4 inhibitors like ipilimumab, faces limited clinical efficacy due to tumor immune evasion and the immunosuppressive tumor microenvironment.
Peng Chang, Kuoye Tian, Xiaoyu Yang, Dehong Chen, Chenying Wang, Ke Li, Dan Chen, Yangyang Feng, Yun Zeng, Yonghua Zhan, Wenhua Zhan   +10 more
doaj   +1 more source

A novel non-sulphamoylated 2-methoxyestradiol derivative causes detachment of breast cancer cells by rapid disassembly of focal adhesions

Cancer Cell International, 2018
Background 2-Methoxyestradiol (2ME2) is an estradiol metabolite with well documented antiproliferative properties in many cancer cell lines. However, it is rapidly metabolised in vivo which limits its clinical application.
Mandie Botes, Tamarin Jurgens, Zohreh Riahi, Michelle Visagie, Rustelle Janse van Vuuren, Anna Margaretha Joubert, Iman van den Bout   +6 more
doaj   +1 more source

Metabolic pathways involved in 2-methoxyestradiol synthesis and their role in preeclampsia

, 2013
Preeclampsia (PE) remains a major cause of maternal/fetal morbidity-mortality worldwide. The first stage of PE is characterized by placental hypoxia due to a relative reduction in uteroplacental blood flow, resulting from restricted trophoblast invasion.
Perez-Sepulveda, Alejandra, Norwitz, Errol R., Illanes, Sebastian E., Espana-Perrot, Pedro P.   +3 more
core   +1 more source