Results 61 to 70 of about 97,768,097 (202)

Deciphering the Chemotherapeutic Mechanism of Ferulic Acid: Insight Into the Role Against Multiple Human Cancers

Cancer Innovation, Volume 5, Issue 2, April 2026.
Ferulic acid (FA), a naturally occurring compound, exhibits anticancer activity against 16 cancer types through multiple molecular pathways. Its enhanced delivery via nanoformulations and synergistic effects with other therapies suggest FA as a promising, food‐based adjunct for cancer symptom control until fully approved pharmaceutical options are ...
Sanzida Khatun, Md Sohel, Zitu Barman, Umme Salma, Lubatul Arbia, Md. Rifat Sarker, Jasmin Akter Jame, Badhan Rani Dey, Sultana Parvin, Md. Shah Poran Shuvo, Md. Shahidul Islam, Tania Mannan, Snygdha Rani Das, Md. Mahmudul Hasan   +13 more
wiley   +1 more source

In vitro cell signaling events of 2-methoxyestradiol-bis-sulphamate in a breast adenocarcinoma- and a non-tumorigenic breast epithelial cell line [PDF]

, 2013
This paper was initially delivered at the Annual Congress of the Biological Sciences Division of the South African Academy for Science and Art, ARC-Plant Protection Research Institute, Roodeplaat, Pretoria, South Africa on 01 October 2010.2 ...
Joubert, Annie M., Visagie, M.H. (Michelle Helen)   +1 more
core   +1 more source

Differential Effects of 17β-Estradiol, Its Metabolites, and Cadmium on Cytotoxicity and Redox-Related Pathways in Doxorubicin-Sensitive and -Resistant Breast Cancer Cell Lines

Pharmaceuticals
Background: Breast cancer is the most common malignancy among women and a leading cause of cancer-related deaths globally. Its development involves hormonal, genetic, environmental and inflammatory factors. Among environmental contributors, cadmium (Cd2+)
Ewa Sawicka, Katarzyna Zdybel, Martyna Wolniak, Agnieszka Piwowar   +3 more
doaj   +1 more source

2-Methoxyestradiol [PDF]

Hypertension, 2017
See related article, pp 1104–1112 Observational studies in humans and experimental studies in animals provide evidence that estrogens protect postmenopausal women against cardiovascular disease.1 However, results from randomized clinical trials do not support this contention.1 The reason(s) for the disparity in the outcome remains unclear and ...
openaire   +4 more sources

2-Methoxyestradiol Induces G2/M Arrest and Apoptosis in Prostate Cancer

, 2001
Few therapeutic treatment options are available for patientssuffering from metastatic androgen-independent prostate cancer. We investigated the ability of the estrogen metabolite 2-methoxyestradiol to inhibit the proliferation of a variety of human ...
Qadan, Laila R, Anderson, Curtis, Perez-Stable, Carlos M, Roos, Bernard A, Herron, Alan, D'Ippolito, Gianluca, Howard, Guy A   +6 more
core   +1 more source

Endogenous oestrogens as neuroprotective modulators in the human retina: Evidence from transcriptomic profiling and aromatase inhibition

Journal of Neuroendocrinology, Volume 38, Issue 4, April 2026.
Single‐cell transcriptomics reveals that the human retina expresses a broad repertoire of steroid hormone biosynthesis and estrogen signalling genes. Functional validation in retinal explants shows that local estrogen synthesis is neuroprotective, preventing photoreceptor death and limiting microglial activation. Abstract Steroid hormones, particularly
Antolin Canto, Javier Valero‐Ochando, Rosa López‐Pedrajas, Teresa Olivar, Vicente Hernández‐Rabaza, Inmaculada Almansa, María Miranda   +6 more
wiley   +1 more source

Hypoxic conditions confer chemoresistance to crizotinib but not to imatinib in chronic myeloid leukemia cells

Hematology, Transfusion and Cell Therapy
Introduction: Chronic myeloid leukemia is an adult leukemia, constituting 15 % of all leukemia diagnoses. The fundamental driver of disease pathogenesis is the Bcr/Abl fusion protein, characterized by dysregulated tyrosine kinase activity.
Lena Avinery, Danielle Regev, Hazem Khamaisi, Jacob Gopas, Jamal Mahajna   +4 more
doaj   +1 more source

Taxol alleviates 2-methoxyestradiol-induced endothelial permeability [PDF]

Vascular Pharmacology, 2012
We have previously shown that the anti-cancer agent 2-methoxyestradiol (2ME) induces hyperpermeability across endothelial monolayers. Here, we show that both microtubule disruptor, 2ME, and microtubule stabilizer, paclitaxel (taxol), increase vascular lung permeability in vitro and in vivo.
Boris A, Gorshkov, Marina A, Zemskova, Alexander D, Verin, Natalia V, Bogatcheva   +3 more
openaire   +2 more sources

2-Methoxyestradiol inhibits progesterone-dependent tissue factor expression and activity in breast cancer cells

, 2010
2-Methoxyestradiol (2ME) is an endogenous metabolite of 17β-estradiol with antiangiogenic and antitumor properties, although its mechanisms of action remain unclear.
Bravo Castillo, María Loreto, Brosens, J. J., Quezada, M., Villalón, Manuel J., Lange, C. A., Oliva, B., Diaz, J., Aranda, E., Owen, Gareth Ivor, Henriquez, S., Cuello F., Mauricio, Kato Cardemil, Sumie Rode   +11 more
core   +1 more source

2-Methoxyestradiol and Its Combination with a Natural Compound, Ferulic Acid, Induces Melanoma Cell Death via Downregulation of Hsp60 and Hsp90 [PDF]

, 2019
Melanoma is an aggressive type of skin cancer with one of the highest mortality rates. Notably, its incidence in the last few decades has increased faster than any other cancer.
Zmijewski M. A., Kuban-Jankowska A., Cappello F., Przychodzen P., Marino Gammazza A., Wozniak M., Kamm A., Daca A., Gorska-Ponikowska M.   +8 more
core   +1 more source