Results 21 to 30 of about 12,682 (158)

Structural characterization of the binding interactions of various endogenous estrogen metabolites with human estrogen receptor α and β subtypes: a molecular modeling study. [PDF]

PLoS ONE, 2013
In the present study, we used the molecular docking approach to study the binding interactions of various derivatives of 17β-estradiol (E2) with human estrogen receptor (ER) α and β. First, we determined the suitability of the molecular docking method to
Pan Wang, Campbell McInnes, Bao Ting Zhu
doaj   +1 more source

Circulating Estradiol Regulates Brain-Derived Estradiol via Actions at GnRH Receptors to Impact Memory in Ovariectomized Rats [PDF]

eneuro, 2016
AbstractSystemic estradiol treatment enhances hippocampus-dependent memory in ovariectomized rats. Although these enhancements are traditionally thought to be due to circulating estradiol, recent data suggest these changes are brought on by hippocampus-derived estradiol, the synthesis of which depends on gonadotropin-releasing hormone (GnRH) activity ...
Nelson, Britta S., Black, Katelyn L., Daniel, Jill M.   +2 more
openaire   +2 more sources

Dose-response effects of estrogenic mycotoxins (zearalenone, alpha- and beta-zearalenol) on motility, hyperactivation and the acrosome reaction of stallion sperm

Reproductive Biology and Endocrinology, 2011
Background The aim of this study was to investigate the in vitro effects of the Fusarium fungus-derived mycotoxin, zearalenone and its derivatives alpha-zearalenol and beta-zearalenol on motility parameters and the acrosome reaction of stallion sperm ...
Colenbrander Ben, Pizzi Flavia, Sostaric Edita, Gadella Bart M, Stout Tom AE, Filannino Angela, Dell'Aquila Maria, Minervini Fiorenza   +7 more
doaj   +1 more source

Retention behaviour of some estradiol derivatives on alumina in normal phase chromatography [PDF]

Journal of the Serbian Chemical Society, 2003
The retention constants of variously substituted estradiol derivatives were measured as a function of the composition of various binary mobile phases in order to study the relationship between chemical structure and retention behaviour in TLC on alumina.
MARIJANA M. ACANSKI
doaj  

In Silico Evaluation of Alpha Mangostin and its Derivatives as a potential Anti-Cancer Agents [PDF]

BIO Web of Conferences
Alpha-Mangostin, a natural xanthone from Garcinia mangostana, and its structurally optimized derivatives were evaluated as anticancer agents targeting estrogen receptor proteins linked to breast cancer: Estrogen Receptor Alpha(3ERT), Estrogen Receptor ...
V Harini Rakshitha, P Maheshwari, P Yamini Devi, Prabhu Puniethaa   +3 more
doaj   +1 more source

Design and Synthesis of Two Bicyclo[3.3.1]nonane-steroid Derivatives

Chemistry Journal of Moldova: General, Industrial and Ecological Chemistry, 2020
This study describes the preparation of two bicyclo[3.3.3]nonane-steroid derivatives from either estradiol or estrone using some reactions such as etherification, addition, nucleophilic substitution and cyclization.
Lauro Figueroa, Alejandra Garcimarero, Rolando Garcia, Francisco Diaz, Marcela Rosas, Virginia Mateu, Maria Lopez, Lenin Hau, Tomas Lopez, Abelardo Camacho, Yaritza Borges   +10 more
doaj   +1 more source

GC-MS/MS Determination of Steroid Hormones in Urine Using Solid-Phase Derivatization as an Alternative to Conventional Methods

Molecules, 2022
Solid-phase analytical derivatization (SPAD) is a promising hybrid sample preparation technique combining the clean-up and preconcentration of the sample in a single step. In this work, a novel SPAD method based on the preparation of trimethylsilyl (TMS)
Azamat Temerdashev, Pavel Nesterenko, Ekaterina Dmitrieva, Kseniya Zhurkina, Yu-Qi Feng   +4 more
doaj   +1 more source

LCAT facilitates transacylation of 17β-estradiol in the presence of HDL3 subfraction

Journal of Lipid Research, 2002
It has been shown that estrogens need to be metabolized to their hydrophobic estrogen ester derivatives to act as antioxidants in lipoproteins. Data suggest that 17β-estradiol (E2) becomes esterified in LCAT-induced reactions and the esters are ...
Anna Höckerstedt, Matti J. Tikkanen, Matti Jauhiainen   +2 more
doaj   +1 more source

Circulating estradiol and its biologically active metabolites in endometriosis and in relation to pain symptoms

Frontiers in Endocrinology, 2023
ObjectivesEndometriosis (EM) is an estrogen-dominant inflammatory disease linked to infertility that affects women of reproductive age. EM lesions respond to hormonal signals that regulate uterine tissue growth and trigger inflammation and pain.
Jean-Philippe Emond, Patrick Caron, Maja Pušić, Véronique Turcotte, David Simonyan, Andrej Vogler, Joško Osredkar, Tea Lanišnik Rižner, Chantal Guillemette, Chantal Guillemette   +9 more
doaj   +1 more source

Novel Locally Active Estrogens Accelerate Cutaneous Wound Healing-Part 2

Scientific Reports, 2017
Estrogen deprivation is associated with delayed healing, while estrogen replacement therapy (ERT) accelerates acute wound healing and protects against development of chronic wounds.
Mario Brufani, Nicoletta Rizzi, Clara Meda, Luigi Filocamo, Francesca Ceccacci, Virginia D’Aiuto, Gabriele Bartoli, Angela La Bella, Luisa M. Migneco, Rinaldo Marini Bettolo, Francesca Leonelli, Paolo Ciana, Adriana Maggi   +12 more
doaj   +1 more source