Results 31 to 40 of about 12,682 (158)

Structure-Activity Relationship Analysis of 3-Phenylcoumarin-Based Monoamine Oxidase B Inhibitors

Frontiers in Chemistry, 2018
Monoamine oxidase B (MAO-B) catalyzes deamination of monoamines such as neurotransmitters dopamine and norepinephrine. Accordingly, small-molecule MAO-B inhibitors potentially alleviate the symptoms of dopamine-linked neuropathologies such as depression ...
Sanna Rauhamäki, Pekka A. Postila, Sanna Niinivehmas, Sami Kortet, Sami Kortet, Emmi Schildt, Emmi Schildt, Mira Pasanen, Elangovan Manivannan, Elangovan Manivannan, Mira Ahinko, Pasi Koskimies, Niina Nyberg, Pasi Huuskonen, Elina Multamäki, Markku Pasanen, Risto O. Juvonen, Hannu Raunio, Juhani Huuskonen, Olli T. Pentikäinen, Olli T. Pentikäinen   +20 more
doaj   +1 more source

Neuronal Nitric Oxide Synthase Induction in the Antitumorigenic and Neurotoxic Effects of 2-Methoxyestradiol

Molecules, 2014
Objective: 2-Methoxyestradiol, one of the natural 17β-estradiol derivatives, is a novel, potent anticancer agent currently being evaluated in advanced phases of clinical trials.
Magdalena Gorska, Alicja Kuban-Jankowska, Michal Aleksander Zmijewski, Monika Gorzynik, Michal Szkatula, Michal Wozniak   +5 more
doaj   +1 more source

ABBV-176, a PRLR antibody drug conjugate with a potent DNA-damaging PBD cytotoxin and enhanced activity with PARP inhibition

BMC Cancer, 2021
Background Prolactin receptor (PRLR) is an attractive antibody therapeutic target with expression across a broad population of breast cancers. Antibody efficacy, however, may be limited to subtypes with either PRLR overexpression and/or those where ...
Mark G. Anderson, Qian Zhang, Luis E. Rodriguez, Claudie M. Hecquet, Cherrie K. Donawho, Peter J. Ansell, Edward B. Reilly   +6 more
doaj   +1 more source

Human Estrogen Receptor Alpha Antagonists, Part 3: 3-D Pharmacophore and 3-D QSAR Guided Brefeldin A Hit-to-Lead Optimization toward New Breast Cancer Suppressants

Molecules, 2022
The estrogen receptor α (ERα) is an important biological target mediating 17β-estradiol driven breast cancer (BC) development. Aiming to develop innovative drugs against BC, either wild-type or mutated ligand-ERα complexes were used as source data to ...
Nezrina Kurtanović, Nevena Tomašević, Sanja Matić, Elenora Proia, Manuela Sabatino, Lorenzo Antonini, Milan Mladenović, Rino Ragno   +7 more
doaj   +1 more source

UV derivative spectrophotometric method for determination of estradiol valerate in tablets [PDF]

Química Nova, 2010
A derivative UV spectrophotometric method for determination of estradiol valerate in tablets was validated. The parameters specificity, linearity, precision, accuracy, limit of detection and limit of quantitation were studied according to validation guidelines.
Mendez, Andreas S. L., Deconto, Lislaine, Garcia, Cássia V.   +2 more
openaire   +5 more sources

Global Metabolomics Reveals Urinary Biomarkers of Breast Cancer in a MCF-7 Xenograft Mouse Model

Metabolites, 2013
Global metabolomics analysis has the potential to uncover novel metabolic pathways that are differentially regulated during carcinogenesis, aiding in biomarker discovery for early diagnosis and remission monitoring.
Frank J. Gonzalez, Melinda G. Hollingshead, Kristopher W. Krausz, Raymond D. Divelbiss, Jessica A. Bonzo, Soumen K. Manna, Caroline H. Johnson   +6 more
doaj   +1 more source

The Potential Effects of Phytoestrogens: The Role in Neuroprotection

Molecules, 2021
Phytoestrogens are naturally occurring non-steroidal phenolic plant compounds. Their structure is similar to 17-β-estradiol, the main female sex hormone.
Justyna Gorzkiewicz, Grzegorz Bartosz, Izabela Sadowska-Bartosz   +2 more
doaj   +1 more source

Design, molecular docking and MD simulation of novel estradiol-pyrimidine analogues as potential inhibitors of Mpro and ACE2 for COVID-19

Chemical Physics Impact
Objectives: Estradiol has become a hot topic in the past few years due to its role in COVID-19. The research on it is started with higher prevalence of COVID-19 in males than in females.
Darakhshan Parveen, Ruhi Ali, M. Shaquiquzzaman, Faizul Azam, Mymoona Akhter, Amisha Gupta, Vivek Kumar, Md. Khalid Saifullah, Mohammad Ahmed Khan, Suhel Parvez, M. Mumtaz Alam   +10 more
doaj   +1 more source

The cholesterol metabolite 25-hydroxycholesterol activates estrogen receptor α-mediated signaling in cancer cells and in cardiomyocytes. [PDF]

PLoS ONE, 2011
The hydroxylated derivatives of cholesterol, such as the oxysterols, play important roles in lipid metabolism. In particular, 25-hydroxycholesterol (25 HC) has been implicated in a variety of metabolic events including cholesterol homeostasis and ...
Rosamaria Lappano, Anna Grazia Recchia, Ernestina Marianna De Francesco, Tommaso Angelone, Maria Carmela Cerra, Didier Picard, Marcello Maggiolini   +6 more
doaj   +1 more source

Comparative proteomic data of M13SV1 human breast epithelial cells and their tumorigenic variants under treatment with estrogenic compounds

Data in Brief, 2016
Data from a comparative proteomic analysis of three human breast epithelial cell lines are presented. M13SV1 cells and their tumorigenic derivatives M13SV1-R2-2 and M13SV1-R2-N1 were used.
Albert Braeuning, Claudia Schmidt, Axel Oberemm, Alfonso Lampen   +3 more
doaj   +1 more source