Results 61 to 70 of about 17,508 (256)

Pharmacological Targeting of DHHC9‐Mediated STRN4 Palmitoylation to Suppress YAP‐Driven Cancer Metastasis

Journal of Cellular and Molecular Medicine, Volume 29, Issue 17, September 2025.
ABSTRACT Protein S‐palmitoylation, a dynamic and reversible post‐translational modification involving the attachment of palmitate to cysteine residues, is a key regulator of protein functionality and cellular signalling. Dysregulation of this modification has emerged as a critical driver of cancer progression.
Yang Tian, Wei Li, Qing Zhai, Ying Yu, Jiaxin Yuan, Yan Ma, Jingjing Yang, Mingyue Li, Wenwen Chang, Wenjing Li, Keke Huang, Chongran Sun, Chen Zeng, Yingdi Sun, Jiabao Gu, Huilin Zhang, Dameng Li, Yanan Yu, Lu Hu, Peng Zhang, Bo Ma, Junnian Zheng, Pan Li, Feng Guo, Yang Sun   +24 more
wiley   +1 more source

Hormone levels and clinicopathological features in patients with thyroid cancer complicated with breast cancer

Zhongguo linchuang yanjiu
Objective To study the hormone levels and clinicopathological characteristics of patients with thyroid cancer and breast cancer, and to explore the possible relationship between the two cancers.
Aliya Tayier, Wufaer Yimaer, Bogela Aersilan, WANG Huguo   +3 more
doaj   +1 more source

GADD45A is Essential for Granulosa Cells Differentiation and Ovarian Reserve in Human and Mice

Journal of Cellular and Molecular Medicine, Volume 29, Issue 17, September 2025.
ABSTRACT Diminished ovarian reserve (DOR) poses significant challenges in reproductive health, with emerging evidence implicating DNA damage repair pathways. While GADD45A is a critical regulator of DNA repair, cell cycle and apoptosis, its role in DOR pathogenesis remains unexplored. We employed transcriptome sequencing, qPCR and Western Blot analyses
Juncen Guo, Yuanyuan Hu, Qi Cao, Ying Zhang, Yihe Jia, Lan Liu, Yanru Zeng, Xiao Wu, Yuelin Song, Maosen Yang, Wenming Xu, Yang Hu, Wei Huang, Tian Tang   +13 more
wiley   +1 more source

TREATMENT FOR THE UROGENITAL DISORDERS, CAUSED BY THE ESTROGEN DEFICIENCY

Акушерство, гинекология и репродукция, 2016
Urogenital disorders (UD) are the common complication of the climacteric syndrome: itching, burning, soreness, vaginal dryness, painful coitus, frequent urinary urgency, urination past bed time, incontinence and poor capability to withhold the urine ...
V. N. Serov
doaj  

Vaginal estriol–lactobacilli combination and quality of life in endocrine-treated breast cancer

Climacteric, 2015
Objective We investigated the effect of a combination of vaginal ultra-low-dose estriol with lactobacilli on the sexual functioning domain of quality of life during the treatment of breast cancer survivors on an aromatase inhibitor with vaginal atrophy ...
S. Buchholz, M. Mögele, A. Lintermans, G. Bellen, V. Prasauskas, O. Ortmann, P. Grob, P. Neven, G. Donders   +8 more
semanticscholar   +1 more source

The estrobolome: Estrogen‐metabolizing pathways of the gut microbiome and their relation to breast cancer

International Journal of Cancer, Volume 157, Issue 4, Page 599-613, 15 August 2025.
Abstract Increasing evidence links the gut microbiome to carcinogenesis. Disruptions in estrogen regulation by the estrobolome—gut microbiota with estrogen‐related functions—may promote breast cancer. However, precise information on estrobolome targets and their underlying mechanisms is limited. This review identifies relevant targets for measuring the
Ashley H. Larnder, Amee R. Manges, Rachel A. Murphy   +2 more
wiley   +1 more source

Effect of ultra-low-dose estriol and lactobacilli vaginal tablets (Gynoflor®) on inflammatory and infectious markers of the vaginal ecosystem in postmenopausal women with breast cancer on aromatase inhibitors

European Journal of Clinical Microbiology and Infectious Diseases, 2015
This study was a detailed microscopic analysis of the changes of vaginal microflora characteristics after application of 0.03 mg estriol-lactobacilli combination on the vaginal ecosystem in postmenopausal breast cancer (BC) survivors on aromatase ...
G. Donders, G. Bellen, P. Neven, P. Grob, V. Prasauskas, S. Buchholz, O. Ortmann   +6 more
semanticscholar   +1 more source

Vaginal atrophy in obstetrician-gynecologist practice [PDF]

Гинекология, 2014
Vaginal atrophy is a characteristic symptom of menopause, which can develop in young women as a result of temporary or permanent deficiency of estrogen, as well as after operations of the cervix or connective tissue diseases.
I G Shestakova
doaj  

Salivary estriol concentrations during normal pregnancies, and a comparison with plasma estriol.

Clinical Chemistry, 1984
Abstract Saliva would have advantages over plasma or urine for monitoring estriol during pregnancy. Specimen collection, after stimulation of flow by citric acid, is non-invasive and simple. We measured concentrations of unconjugated estriol in saliva and compared them with those in plasma in normal pregnancies, and found a good ...
A R Wilkinson, D R Aickin, J J Evans
openaire   +3 more sources

Impact of exercise on sexual health, body image, and therapy‐related symptoms in women with metastatic breast cancer: The randomized controlled PREFERABLE‐EFFECT trial

International Journal of Cancer, Volume 157, Issue 3, Page 490-503, 1 August 2025.
What's new? Women with metastatic breast cancer often experience non‐life‐threatening but unpleasant symptoms, including low sexual enjoyment and vaginal dryness, but these symptoms have not been well‐studied and treatments are lacking. Here, the authors conducted a large, multinational randomized controlled trial of exercise in women with metastatic ...
Martina E. Schmidt, Anouk E. Hiensch, Johanna Depenbusch, Evelyn M. Monninkhof, Jon Belloso, Dorothea Clauss, Nadira Gunasekara, Mark Trevaskis, Helene Rundqvist, Joachim Wiskemann, Jana Müller, Maike G. Sweegers, Andreas Schneweiss, Renske Altena, Joanna Kufel‐Grabwska, Rhodé M. Bijlsma, Lobke van Leeuwen‐Snoeks, Daan ten Bokkel Huinink, Gabe Sonke, Susanne Brandner, Peter Savas, Yoland Antill, Michelle White, Nerea Ancizar, Elsken van der Wall, Neil K. Aaronson, Elzbieta Senkus, Ander Urruticoechea, Eva M. Zopf, Wilhelm Bloch, Martijn M. Stuiver, Yvonne Wengström, Anne M. May, Karen Steindorf   +33 more
wiley   +1 more source