Results 131 to 140 of about 341,736 (266)

Multicomponent Stapling of Glucagon‐Like Peptide‐1 Enables Receptor‐Guided PROTAC Delivery

Angewandte Chemie, EarlyView.
We report a stapled glucagon‐like peptide‐1 (GLP‐1) analogue created via multicomponent tryptophan‐mediated Petasis reaction (TMPR). This strategy yields a stabilised peptide with superior helicity and improved potency. Conjugation to a bromodomain‐containing protein 4 (BRD4) degrader creates the first GLP‐1‐guided targeted protein degrader (PROTAC ...
Jan L. Venne, Sona Krajcovicova, Graeme Davies, Hannah Bolt, Jefferson Revell, David R. Spring   +5 more
wiley   +2 more sources

The liver‐brain axis: A multidimensional regulatory network implicated in Alzheimer's disease pathogenesis and clinical implications

Animal Models and Experimental Medicine, EarlyView.
Schematic diagram of the core pathways of the liver‐brain axis in regulating AD. The liver regulates cerebral Aβ deposition, tau phosphorylation, and neuroinflammation through pathways such as metabolic detoxification (urea cycle, ketone body metabolism, glutathione antioxidant system), molecular secretion (APOE, CRP, FGF21, IGF‐1), and Aβ clearance ...
Ning Zhang, Wei Chen, Meng Wang
wiley   +1 more source

Steroid hormones dynamics during coral reproduction: Multi-year patterns in <i>Acropora eurystoma</i> from the Red Sea. [PDF]

iScience
Azulay C, Kleinhaus K, Fine M.
europepmc   +1 more source

Sex Differences in the Association of Simultaneous Decline in Blood Pressure and Decline in Cognition during Aging

Annals of Neurology, EarlyView.
Objective Both high and declining blood pressure (BP) are associated with risk of cognitive decline in older adults, and women have higher rates of hypertension and faster cognitive decline in late‐life. In old age, the relationship between changes in BP and changes in cognition is complex, and although sex differences in cognitive function and decline
Nicholas W. Baumgartner, Ana W. Capuano, Lisa L. Barnes, David A. Bennett, Zoe Arvanitakis   +4 more
wiley   +1 more source

Distinct Responses of Estrogen Receptor α and β in Chondrocytes Under Excessive Mechanical Stress. [PDF]

Cartilage
Takesue S, Hirose N, Yanoshita M, Nishiyama S, Tsuboi E, Kubo N, Kita D, Asakawa Y, Tanimoto K.   +8 more
europepmc   +1 more source

The Microbiota-Endometriosis Axis: An Immune-Endocrine Integration Model and Emerging Therapeutic Targets. [PDF]

Int J Mol Sci
Nemeti G, Crăciun AE, Măgureanu DC, Militaru FC, Bocsan IC, Crăciun CI, Rusu A, Melincovici CS, Buzoianu AD, Mureșan D, Neag MA.   +10 more
europepmc   +1 more source

Loss of Brain-Derived Estrogen Is Associated With Sex- and Age-Dependent Alterations in Memory, Affective Behavior, and Hippocampal Extracellular Matrix Gene Expression. [PDF]

Aging Cell
Piehl NC, Halle AW, Rodriguez G, Locci A, Kujawa S, Haywood C, Coon J, McNally RP, Karim ZA, You T, Dong H, Bulun SE, Zhao H.   +12 more
europepmc   +1 more source

Hormonal Stabilization of the Bone-Metabolic Environment: Implications for Anterior Cruciate Ligament Integrity and Bone-Graft Integration. [PDF]

J Bone Metab
Koren A, Koren L.
europepmc   +1 more source

Brainstem Astrocytes Regulate Estrus-Dependent Oscillations in Food Intake. [PDF]

J Neurochem
Ozkaya KS, Yalcin C, Haar EE, Bhagat R, Browning KN.   +4 more
europepmc   +1 more source

Association of Endocrine Conditions With Takotsubo Cardiomyopathy: A Comprehensive Review

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2018
Sonali Gupta, Pradeep Goyal, Sana Idrees, Sourabh Aggarwal, Divyansh Bajaj, Joseph Mattana   +5 more
doaj   +1 more source