Results 141 to 150 of about 659,381 (316)
Advanced Science, EarlyView.This study identifies a FOSL2‐driven positive feedback loop that amplifies FSH/FSHR signaling. During FSH‐dependent follicle maturation, FSH induces Fosl2 expression via the cAMP‐PKA‐CREB cascade. FOSL2 in turn binds the promoters of Fshr and estrogen‐biosynthesis genes to enhance their transcription, thereby increasing Fshr mRNA level and amplifying ...
Hongru Shi +13 more
wiley +1 more source
Role of Calcium in an Experimental Breast Cancer Model Induced by Radiation and Estrogen
BiomedicinesBackground: Breast cancer, a global health challenge, significantly impacts women worldwide, causing morbidity, disability, and mortality. Objectives: To analyze the role of genes encoding S100 calcium-binding proteins and their relationship with ...
Gloria M. Calaf +2 more
doaj +1 more source
Estrogen-Mimicking Cellular Mechanism and Toxicologic Developmental Effects of BPA Derivatives [PDF]
, 2019 Undergraduate ...
Clines, Lauren +2 more
core +1 more source
Selenium‐Based Nanoplatforms: An Emerging Theranostic Paradigm for Gynecological Cancers
Advanced Science, EarlyView.This reivew summarizes Selenium as a multifunctional anticancer regulator in gynecological cancers. It reduces tumor risk, enhances therapeutic efficacy, and reduces treatment toxicity. Selenium also overcomes chemoraditherapy resistance, improving overall treatment outcomes. ABSTRACT Gynecological cancers present significant therapeutic challenges due
Hejing Liu +9 more
wiley +1 more source
Physiological ReportsMenstrual cycle peak estradiol occurs in the late follicular (LF) phase just prior to the luteinizing hormone (LH) surge and ovulation. Therefore, to examine the impact of menstrual cycle estradiol fluctuations, it is desirable to perform assessments ...
Lindsay A. Lew, Kyra E. Pyke
doaj +1 more source
Advanced Science, EarlyView.NET‐DNA is enriched during early endometriotic lesion establishment and drives anoikis resistance by promoting an ANXA2–TMEM215–BiP axis. This pathway strengthens ER–mitochondria contacts, enhances PINK1/Parkin‐associated mitophagy, preserves mitochondrial homeostasis, and supports ectopic stromal cell survival, thereby facilitating lesion persistence ...
Honglin Wang +12 more
wiley +1 more source
A Population‐Based Correlation Analysis Between Hemoglobin A1c and Hemoglobin Levels
Journal of DiabetesBackground Glycated hemoglobin (HbA1c) is widely used to assess long‐term glycemic control in individuals with diabetes. However, various conditions that affect hemoglobin levels or the lifespan of red blood cells can compromise the accuracy of HbA1c ...
Tingyu Zhang +9 more
doaj +1 more source
Dibenzo[a,g]quinolizin-8-ones: synthesis, estrogen receptor affinities, and cytostatic activity [PDF]
, 1992 A number of acetoxy-substituted dibenzo[a,g]quinolizin-8-ones were synthesized by the reaction of 1-oxoisoquinolines with substituted homophthalic acid anhydride.
Angerer, S. von +4 more
core
AGING MEDICINE, EarlyView.Bibliometric analysis reveals rising global research on physical activity and elderly health, dominated by developed nations. Key hotspots include healthy aging, physical activity's mental health benefits, and VR exercise interventions. Promoting physical activity is vital for healthy aging, requiring greater technology integration and research from ...
Hongman Wang +3 more
wiley +1 more source
Estrogen and Cyp1b1 Regulate Pparγ in Pulmonary Hypertension Through a Ubiquitin‐Dependent Mechanism
Pulmonary CirculationFemale sex increases risk of Group I pulmonary arterial hypertension by roughly threefold, but the mechanism is unclear. Low expression of Cyp1b1, an enzyme that metabolizes estrogens, is associated with disease penetrance, particularly in women.
Jingyuan Chen +10 more
doaj +1 more source