Results 161 to 170 of about 709,941 (344)

A Dynamic Contrast‐Enhanced MRI‐Based Vision Transformer Model for Distinguishing HER2‐Zero, ‐Low, and ‐Positive Expression in Breast Cancer and Exploring Model Interpretability

Advanced Science, EarlyView.
This study develops a Vision Transformer‐based DCE‐MRI model for the non‐invasive classification of HER2 expression in breast cancer, demonstrating robust performance across multicenter cohorts. By integrating transcriptomic analysis, the model reveals immune‐related pathway differences among distinct HER2 expression levels.
Xu Zhang, Yi‐Yuan Shen, Guan‐Hua Su, Yuan Guo, Ren‐Cheng Zheng, Si‐Yao Du, Si‐Yi Chen, Yi Xiao, Zhi‐Ming Shao, Li‐Na Zhang, He Wang, Yi‐Zhou Jiang, Ya‐Jia Gu, Chao You   +13 more
wiley   +1 more source

Reproductive Ability of Chickens Implanted at Nine Weeks of Age with Estrogen Pellets

, 1953
Ahmet C. Akpinar, C.S. Shaffner
openalex   +1 more source

Detection of Estrogenic Substances in Alfalfa and Clover Hays Fed to Fattening Lambs [PDF]

, 1953
Edmund W. Cheng, Charles D. Story, Loyal C. Payne, Lester Yoder, Wise Burroughs   +4 more
openalex   +1 more source

Estrogen receptor-1 is a key regulator of HIV-1 latency that imparts gender-specific restrictions on the latent reservoir. [PDF]

, 2018
Unbiased shRNA library screens revealed that the estrogen receptor-1 (ESR-1) is a key factor regulating HIV-1 latency. In both Jurkat T cells and a Th17 primary cell model for HIV-1 latency, selective estrogen receptor modulators (SERMs, i.e ...
Bacchetti, Peter, Chomont, Nicolas, Das, Biswajit, Deeks, Steven G, Dobrowolski, Curtis, Gandhi, Monica, Hoh, Rebecca, Johnston, Rowena, Karn, Jonathan, Luttge, Benjamin, Scully, Eileen, Valadkhan, Saba   +11 more
core  

GHSR‐Foxo1 Signaling in Macrophages Promotes Liver Fibrosis via Inflammatory Response and Hepatic Stellate Cell Activation

Advanced Science, EarlyView.
Macrophage GHSR‐Foxo1 axis regulates CCl4‐induced liver fibrosis by promoting inflammation and TGF‐β1‐mediated HSC activation. GHSR activates PKA‐dependent phosphorylation of Foxo1 at serine 273, promoting macrophage pro‐inflammatory polarization to enhance the production of pro‐inflammatory cytokines that damage hepatocytes, thereby inducing liver ...
Da Mi Kim, Quan Pan, Zeyu Liu, Weiqi Ai, Hye Won Han, Sakhila K. Banu, Robert Y.L. Tsai, Gus A. Wright, Shaodong Guo, Yuxiang Sun   +9 more
wiley   +1 more source

Relation between dairy performance and mammary glands and their stimulators. III. Free and protein bound estrogen levels in the blood of goats treated with synthetic estrogen for induced lactation and their relationships with lactation results.

, 1959
H. Nagasawa, Ayako Kohno, Yoichi SHODA, Masatoshi Naito   +3 more
openalex   +2 more sources

STUDIES CONCERNING THE MECHANISM CONTROLLING THE INITIATION OF LACTATION AT PARTURITION III. CAN ESTROGEN ACCOUNT FOR THE PRECIPITOUS INCREASE IN THE LACTOGEN CONTENT OF THE PITUITARY FOLLOWING PARTURITION?¹,² [PDF]

, 1942
J. Meites, C. W. Turner
openalex   +1 more source

Neutrophil–Endothelium Interaction Mediated by S100A9 Promotes Pulmonary Vascular Remodeling During Pulmonary Hypertension

Advanced Science, EarlyView.
This study investigates the critical mechanisms underlying pulmonary hypertension progression, with a focus on the novel role of neutrophil‐derived S100A9 in endothelial dysfunction‐mediated pulmonary vascular remodeling. By integrating human lung samples, multi‐omics analyses, animal models, and mechanistic in vitro studies, it is revealed that how ...
Yu Guo, Zhenqiang Gao, Ruoyang Zhang, Huanyu Long, Muzhi Zhang, Lin Liu, Zhe An, Yuezhe Shi, Ye Cui, Yufeng Jia, Lei Wang, Ying Sun, Jie Liu, Wei Wang   +13 more
wiley   +1 more source

On the Identity of the Estrogen-Sensitive Enzyme of Human Placenta

, 1958
Claude A. Villee, Dwain D. Hagerman
openalex   +1 more source

Pyroptosis‐Inducing Platinum(IV) Prodrugs via GSDME Pathway for Chemoimmunotherapy and Metastasis Inhibition in Triple‐Negative Breast Cancer

Advanced Science, EarlyView.
Three PtIV prodrugs MRP, DRP, and HRP are designed to induce pyroptosis in low GSDME‐expressing tumor cells via the Caspase‐3/GSDME pathway. By relaxing chromatin and reactivating GSDME, HRP can effectively induce pyroptosis, enhance pro‐inflammatory cytokine production, and exhibit potent antitumor effects.
Xinda Yang, Chuansheng Xu, Youliang Zeng, Chunhui Wang, Yan Gao, Jie Ding, Sirui Chen, Yuheng Pan, Xin Zhang, Zongwan Mao, Shuo Shi   +10 more
wiley   +1 more source