Results 301 to 310 of about 709,941 (344)

Estrogen protects against postpartum Concanavalin A-induced hepatitis by promoting intrahepatic CD4⁺CD25⁺ Treg expansion through activation of the PI3K/Akt signaling pathway in HBV-Tg mice. [PDF]

Virol J
Xu C, Su Y, Lu W, Dong J, Wang L, Mi Y, Jia X, Lv W, Wu S, Jia Y, Ying H.   +10 more
europepmc   +1 more source

Pharmacokinetics, Safety, and Skin Irritation and Sensitization Potential of Clascoterone Cream in Early‐Phase Clinical Study Participants

Clinical Pharmacology in Drug Development, EarlyView.
Abstract Clascoterone is an androgen receptor inhibitor approved for the treatment of acne vulgaris in patients 12 years of age and older. Here, we report results of 5 phase 1 studies that assessed the pharmacokinetics (PK), safety, and skin irritation and sensitization potential of clascoterone cream 1% in healthy participants and patients with acne ...
Andrea Francesco Daniele Di Stefano, Milko Massimiliano Radicioni, Gerhard Garhöfer, Martina Cartwright, Markus Müller, Iris Kopeloff, Luigi Moro, Nicholas Squittieri, Alessandro Mazzetti   +8 more
wiley   +1 more source

Chronic Phase Shifts Are Associated With Higher Systolic Blood Pressure and Impaired Glucose Tolerance Independently of Estrogen Deficiency in Female Spontaneously Hypertensive Rats. [PDF]

J Biol Rhythms
Nthlane RA, Scheuermaier K, Mkhize SA, Michel FS.   +3 more
europepmc   +1 more source

Disposition and Absolute Bioavailability of Oral Imlunestrant in Healthy Women: A Phase 1, Open‐Label Study

Clinical Pharmacology in Drug Development, EarlyView.
Abstract Imlunestrant (LY3484356) is a next‐generation orally bioavailable selective estrogen receptor degrader being investigated for the treatment of estrogen receptor–positive advanced breast and endometrial cancers. This Phase 1, open‐label, 2‐part study evaluated the disposition and absolute bioavailability of [14C]‐imlunestrant in 16 US‐based ...
Amita Datta‐Mannan, Boris Czeskis, Elaine Shanks, Eunice Yuen, Stephen Hall, Vivian Rodriguez Cruz, Kenneth Cassidy   +6 more
wiley   +1 more source

Estrogen rescues muscle regeneration impaired by DUX4 in a humanized xenograft mouse model. [PDF]

Cell Death Dis
Maiullari S, Mele G, Calandra P, di Blasio G, Valentini S, Torcinaro A, Manni I, Teveroni E, Mancino F, Proietti L, Maiullari F, Pesavento M, Giorgini L, Putti S, Rizzi R, Bortolani S, Scavizzi F, Raspa M, Ricci E, Piaggio G, Gargioli C, Pontecorvi A, Luvisetto S, Mazzone M, Deidda G, Moretti F.   +25 more
europepmc   +1 more source

The GPR30 agonist G-1 promotes hair growth via Wnt/Hedgehog signaling in mice. [PDF]

Front Pharmacol
Yamano M, Yamanaka Y, Nishikawa S, Masujima Y, Ohue-Kitano R, Kimura I.   +5 more
europepmc   +1 more source

Emerging and accumulating safety signals for the use of estrogen among transgender women. [PDF]

Discov Ment Health
Schwartz L, Lal M, Cohn J, Mendoza CD, MacMillan L.   +4 more
europepmc   +1 more source

RAMP1-dependent hormonal regulation of CGRP and its receptor in the trigeminal ganglion. [PDF]

J Headache Pain
Holm A, Edvinsson JCA, Krause DN, Edvinsson L.   +3 more
europepmc   +1 more source

Labial Adhesion in Postmenopausal Women: A Case Report. [PDF]

Cureus
Paracha AWA, Giang V, Shehaj A, Ali M, Herrera Caceres J.   +4 more
europepmc   +1 more source

Relationship Between Chronic Body Pain and Depression Among Middle‐Aged and Elderly People in China: A Longitudinal Population‐Based Study From CHARLS

Chronic Diseases and Translational Medicine, EarlyView.
Jiaying Wang, Kai Wang, Qingxia Gao, Wenchang Xu, Gongchang Yu, Bin Shi   +5 more
wiley   +1 more source