Results 1 to 10 of about 1,539,304 (263)

Targeting Estrogen Receptor for Breast Cancer [PDF]

Current Issues in Molecular Biology
With a lifetime risk estimated to be 1 in 8 in industrialized countries, breast cancer is the most frequent type of cancer among women worldwide and the second leading cause of cancer deaths in women.
Eugenia Yiannakopoulou
doaj   +2 more sources

Sensitive detection of unopposed estrogen using estrogen receptor functionalized nanoprobes for cancer diagnosis [PDF]

Discover Nano
Unopposed estrogen refers to prolonged estrogenic stimulation in the absence of adequate progesterone-mediated counter-regulation. Unopposed estrogen is strongly implicated in endometrial hyperplasia and type I endometrial carcinogenesis, and it is also ...
Daniel Ejim Uti, Esther Ugo Alum, Celestine O. Ogbu, Okechukwu Paul-Chima Ugwu, Godwin Eneji Egbung, Item Justin Atangwho, Mequanente Dagnaw, Asif Jan   +7 more
doaj   +2 more sources

Cyclopia extracts act as selective estrogen receptor subtype downregulators in estrogen receptor positive breast cancer cell lines: Comparison to standard of care breast cancer endocrine therapies and a selective estrogen receptor agonist and antagonist

Frontiers in Pharmacology, 2023
Breast cancer is the most diagnosed type of cancer amongst women in economically developing countries and globally. Most breast cancers express estrogen receptor alpha (ERα) and are categorized as positive (ER+) breast cancer. Endocrine therapies such as,
Folasade R. Olayoku, Nicolette J. D. Verhoog, Ann Louw   +2 more
doaj   +1 more source

Screening and characterization estrogen receptor ligands from Arnebia euchroma (Royle) Johnst. via affinity ultrafiltration LC-MS and molecular docking

Frontiers in Plant Science, 2022
Arnebiae Radix (dried root of Arnebia euchroma (Royle) Johnst.) is a traditional Chinese medicine (TCM) used to treat macular eruptions, measles, sore throat, carbuncles, burns, skin ulcers, and inflammations.
Lian Zhu, Lian Zhu, Sheng-jun Ma, Ming-juan Liu, Kai-lin Li, Shuai E, Zi-ming Wang, Sha-ni Li, Sheng-lan Zhang, Wei Cai   +9 more
doaj   +1 more source

Effect of combining CBD with standard breast cancer therapeutics

Advances in Cancer Biology - Metastasis, 2022
Breast cancer is the most common malignancy in women worldwide. Sixty-five percent of breast cancers are estrogen and/or progesterone receptor positive.
Luka Dobovišek, Metka Novak, Fran Krstanović, Simona Borštnar, Tamara Lah Turnšek, Nataša Debeljak   +5 more
doaj   +1 more source

Significance of G Protein-Coupled Estrogen Receptor in the Pathophysiology of Irritable Bowel Syndrome, Inflammatory Bowel Diseases and Colorectal Cancer

Frontiers in Endocrinology, 2020
The regulatory role of estrogens and nuclear estrogen receptors, i. e., estrogen receptor α and β has been reported in gastrointestinal diseases. However, the contribution of G protein-coupled estrogen receptor, the membrane-bound estrogen receptor, is ...
Damian Jacenik, Wanda M. Krajewska
doaj   +1 more source

Role of estrogen receptors in cancer: a special emphasis on the therapeutic potential of estrogen receptor β [PDF]

Pharmaceutical Sciences Asia, 2022
Estrogen receptors are nuclear receptors that play a major role in both physiology and pathology. Estrogen receptor subtypes are currently divided into three groups: estrogen receptor alpha (ERα), estrogen receptor beta (ERβ), and G protein-coupled ...
Emdormi Rymbai, Deepa Sugumar, Dhritiman Roy, Divakar Selvaraj   +3 more
doaj   +1 more source

The rate of estrogen receptor‐conversion associated with tumor progression in estrogen receptor‐positive breast cancer patients following adjuvant Tamoxifen administration

Cancer Reports, 2022
Background Hormone Receptor (HR)‐discordance between primary breast cancer and metastasis is a known biological phenomenon. Discordance studies usually comprise a heterogeneous group of HR‐positive and negative patients and allow for the comparison of ...
Sirus Djahansouzi, Bettina Hanstein, Daniel Rein, Michel Clees, Werner Rath   +4 more
doaj   +1 more source

PARP7 and Mono-ADP-Ribosylation Negatively Regulate Estrogen Receptor α Signaling in Human Breast Cancer Cells

Cells, 2021
ADP-ribosylation is a post-translational protein modification catalyzed by a family of proteins known as poly-ADP-ribose polymerases. PARP7 (TIPARP; ARTD14) is a mono-ADP-ribosyltransferase involved in several cellular processes, including responses to ...
Marit Rasmussen, Susanna Tan, Venkata S. Somisetty, David Hutin, Ninni Elise Olafsen, Anders Moen, Jan H. Anonsen, Denis M. Grant, Jason Matthews   +8 more
doaj   +1 more source

Estrogen Biosynthesis and Signal Transduction in Ovarian Disease

Frontiers in Endocrinology, 2022
Estrogen mainly binds to estrogen receptors (ERs) to regulate menstrual cycles and reproduction. The expression of ERalpha (ERα), ERbeta (ERβ), and G-protein-coupled estrogen receptor (GPER) mRNA could be detected in ovary, suggesting that they play an ...
Xue-Ling Xu, Zheng-Yuan Huang, Kun Yu, Jun Li, Xiang-Wei Fu, Shou-Long Deng   +5 more
doaj   +1 more source