Results 11 to 20 of about 276,776 (266)

Estrogen Receptors and Endothelium [PDF]

Arteriosclerosis, Thrombosis, and Vascular Biology, 2010
Estrogens, and in particular 17β-estradiol (E2), play a pivotal role in sexual development and reproduction and are also implicated in a large number of physiological processes, including the cardiovascular system. Both acetylcholine-induced and flow-dependent vasodilation are preserved or potentiated by estrogen treatment in both animal models and ...
Arnal, Jean-François, Fontaine, Coralie, Billon-Galés, Audrey, Favre, Julie, Laurell, Henrik, Lenfant, Françoise, Gourdy, Pierre   +6 more
openaire   +3 more sources

Reference Profile Correlation Reveals Estrogen-like Trancriptional Activity of Curcumin [PDF]

, 2010
Background: Several secondary metabolites from herbal nutrient products act as weak estrogens (phytoestrogens), competing with endogenous estrogen for binding to the estrogen receptors and inhibiting steroid converting enzymes.
Beatrice E. Bachmeier, Ulrich Pfeffer, Killian, Peter H., Blengio, Fabiola, Valentina Mirisola, Romeo, Francesco, Dell'Eva, Raffaella, Pfeffer, Ulrich, Luca Generoso, Fabiola Blengio, Alessia Esposito, Raffaella Dell’Eva, Mirisola, Valentina, Generoso, Luca, Albini, Adriana, Adriana Albini, Peter H. Killian, Bachmeier, Beatrice E., Esposito, Alessia, Francesco Romeo   +19 more
core   +1 more source

Insights from the Structure of Estrogen Receptor into the Evolution of Estrogens: Implications for Endocrine Disruption

, 2011
In the last decade, there has been important progress in understanding the origins and evolution of receptors for adrenal steroids (aldosterone, cortisol) and sex steroids (estradiol, progesterone, testosterone) due to the sequencing of genomes from ...
Michael E. Baker
core   +1 more source

Dynamic changes in gene expression in vivo predict prognosis of tamoxifen-treated patients with breast cancer [PDF]

, 2010
Tamoxifen is the most widely prescribed anti-estrogen treatment for patients with estrogen receptor (ER)-positive breast cancer. However, there is still a need for biomarkers that reliably predict endocrine sensitivity in breast cancers and these may ...
Liang, Liang, J Michael Dixon, Muir, Morwenna, David A Cameron, Walker, Graeme, Sims, Andrew H., Morwenna Muir, Liang Liang, Muir, Morwenna; id_orcid, Langdon, Simon P., Dixon, J. Michael, Sims, Andrew, Taylor, Karen J., Dana Faratian, Graeme Walker, Cameron, David A., Simon P Langdon, Dixon, Mike, Karen J Taylor, Taylor, Karen J, Harrison, David J, Barbara Kuske, David J Harrison, Cameron, David A, Faratian, Dana, Kuske, Barbara, Andrew H Sims, Langdon, Simon P, Harrison, David J.   +28 more
core   +1 more source

Epigenetics and the Estrogen Receptor

Annals of the New York Academy of Sciences, 2006
Abstract:  The position effect variegation in Drosophila and Schizosaccharomyces pombe, and higher‐order chromatin structure regulation in yeast, is orchestrated by modifier genes of the Su(var) group, (e.g., histone deacetylases ([HDACs]), protein phosphatases) and enhancer E(Var) group (e.g., ATP [adenosine 5′‐triphosphate]‐dependent nucleosome ...
Leader, Jennifer E., Wang, Chenuang, Popov, Vladimir M., Fu, Maofu, Pestell, Richard G.   +4 more
openaire   +3 more sources

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

Molecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel, Peyman Zarrineh, Nathnael T. Tuffa, Jigar H. Sheth, Sumitra Mohan, Mudassar Iqbal, Sankari Nagarajan   +6 more
wiley   +1 more source

Field and laboratory approaches to assess "estrogen disruption" in the brown trout "Salmo trutta" [PDF]

, 2008
In recent years, the annual catches of brown trout and other native fish species have been declining in Switzerland about 60%. One hypothesis was that the reduced catch is linked to estrogen-active chemicals entering the aquatic environment via waste ...
Körner, Oliver
core   +1 more source

Estrogen Receptors in the Male [PDF]

Archives of Andrology, 1981
Estrogens in the male are secreted by the testes and derived extragonadally from the aromatization of certain androgens. In some brain regions critical for the control of gonadotropin secretion and behavior, androgens may be aromatized to estrogens within the cells that are regulated. Estrogen may have other physiological roles on the testes to control
R B, Dickson, C R, Clark
openaire   +2 more sources

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

Effects of estrogen receptor and estrogen on the chromatin structure in estrogen receptor stable transfectants [PDF]

Experimental & Molecular Medicine, 2002
The estrogen receptor (ER), a member of the nuclear hormone receptor superfamily recruits coactivators that modify local chromatin structure. Here we investigated the effect of the estrogen receptor and estrogen on the global chromatin structure and the local chromatin structure of the progesterone receptor gene during the process of transcriptional ...
Young Joo, Lee, Won Chung, Lim, Ying Hua, Jin, Seung Ki, Lee   +3 more
openaire   +2 more sources