Results 11 to 20 of about 1,539,304 (263)

Insights from the Structure of Estrogen Receptor into the Evolution of Estrogens: Implications for Endocrine Disruption [PDF]

, 2011
In the last decade, there has been important progress in understanding the origins and evolution of receptors for adrenal steroids (aldosterone, cortisol) and sex steroids (estradiol, progesterone, testosterone) due to the sequencing of genomes from ...
Michael E. Baker
core   +1 more source

Enhanced Resistance to Tamoxifen by the c-ABL Proto-oncogene in Breast Cancer

Neoplasia: An International Journal for Oncology Research, 2010
Targeting the estrogen receptor is an important strategy in breast cancer therapy. However, although inhibiting estrogen receptor function with specific estrogen receptor modulators can achieve a primary response in cancer patients, intrinsic or ...
Huajun Zhao, Fu Ou-Yang, I-Fen Chen, Ming-Feng Hou, Shyng-Shiou F. Yuan, Hsueh-Ling Chang, Yi-Chen Lee, Rina Plattner, Susan E. Waltz, Shuk-Mei Ho, Jonathan Sims, Shao-Chun Wang   +11 more
doaj   +1 more source

Dopaminergic activation of estrogen receptors induces fos expression within restricted regions of the neonatal female rat brain. [PDF]

PLoS ONE, 2008
Steroid receptor activation in the developing brain influences a variety of cellular processes that endure into adulthood, altering both behavior and physiology.
Kristin M Olesen, Anthony P Auger
doaj   +1 more source

Expression and function of estrogen receptors and estrogen-related receptors in the brain and their association with Alzheimer’s disease

Frontiers in Endocrinology, 2023
While estrogens are well known for their pivotal role in the female reproductive system, they also play a crucial function in regulating physiological processes associated with learning and memory in the brain. Moreover, they have neuroprotective effects
Kaoru Sato, Kaoru Sato, Ken-ichi Takayama, Satoshi Inoue   +3 more
doaj   +1 more source

VULCAN integrates ChIP-seq with patient-derived co-expression networks to identify GRHL2 as a key co-regulator of ERa at enhancers in breast cancer

Genome Biology, 2019
Background VirtUaL ChIP-seq Analysis through Networks (VULCAN) infers regulatory interactions of transcription factors by overlaying networks generated from publicly available tumor expression data onto ChIP-seq data.
Andrew N. Holding, Federico M. Giorgi, Amanda Donnelly, Amy E. Cullen, Sankari Nagarajan, Luke A. Selth, Florian Markowetz   +6 more
doaj   +1 more source

Immunoekspresi Reseptor α pada Poket Periodontal Lebih Banyak daripada Reseptor Estrogen β

Journal of Dentistry Indonesia, 2013
Studies have been reported on the association between menopause and periodontal disease related to estrogen deficiency. Although the estrogen receptor has been demonstrated on some oral tissues, the presence of estrogen receptors on periodontal pockets ...
Yuliana Mahdiyah Da’at Arina
doaj   +1 more source

An emerging generation of endocrine therapies in breast cancer: a clinical perspective

npj Breast Cancer, 2023
Anti-estrogen therapy is a key component of the treatment of both early and advanced-stage hormone receptor (HR)-positive breast cancer. This review discusses the recent emergence of several anti-estrogen therapies, some of which were designed to ...
Rima Patel, Paula Klein, Amy Tiersten, Joseph A. Sparano   +3 more
doaj   +1 more source

Genistein modulates the estrogen receptor and suppresses angiogenesis and inflammation in the murine model of peritoneal endometriosis

Journal of Traditional and Complementary Medicine, 2018
The purpose of this study was to investigate the effect of genistein administration on the modulation of the estrogen receptor, inhibition of inflammation and angiogenesis in the murine model of peritoneal endometriosis.
Sutrisno Sutrisno, Hardianti Aprina, Happy Marthalena Simanungkalit, Asti Andriyani, Wisnu Barlianto, Hidayat Sujuti, Sanarto Santoso, Pande Made Dwijayasa, Endang Sri Wahyuni, Edy Mustofa   +9 more
doaj   +1 more source

Efficacy of Fractional Laser on Steroid Receptors in GSM Patients

Bioengineering, 2023
Background: To compare the efficacy of CO2 fractional laser with that of topical estriol for treating genitourinary syndrome of menopause and to investigate the relationship between epithelial thickness and vaginal atrophy.
Stella Catunda Pinho, Thais Heinke, Paula Fernanda Santos Pallone Dutra, Andreia Carmo, Camilla Salmeron, Luciana Karoleski, Gustavo Focchi, Neila Maria Góis Speck, Beatrice Marina Pennati, Ivaldo Silva   +9 more
doaj   +1 more source

Lapatinib in the Treatment of Hormone Receptor-Positive/ErbB2-Positive Breast Cancer [PDF]

, 2010
In women with estrogen receptor(ER)- and ErbB2(HER2)-positive breast cancer, a vicious cycle is established between ER mechanisms of action and the growth factor receptor network, leading to enhanced cell proliferation and endocrine resistance.
Bauerfeind, Ingo, Elling, Dirk, Heinemann, Volker   +2 more
core   +1 more source